A semi‐automated ASC speck assay to evaluate pyrin inflammasome activation [PDF]
Clinical & Translational ImmunologyObjective To develop a rapid functional assay to validate variants of uncertain significance (VUS) in the MEFV gene. Methods Overactivity of the pyrin inflammasome pathway and ASC speck oligomerisation in response to stimulation with low concentrations ...
Pei Dai +21 more
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Pyrin- and CARD-only Proteins as Regulators of NLR Functions [PDF]
Frontiers in Immunology, 2013 Upon activation Nod-like receptors (NLRs) assemble into multi-protein complexes such as the NODosome and inflammasome. This process relies upon homo-domain interactions between the structurally related Pyrin and caspase-recruitment (CARD) domains and ...
Hongnga T Le, Jonathan A Harton
exaly +4 more sources
The PRY/SPRY domain of pyrin/TRIM20 interacts with β2-microglobulin to promote inflammasome formation [PDF]
Scientific Reports, 2021 Pyrin/TRIM20 is expressed in the neutrophils and monocytes/macrophages and regulates caspase-1 activation and interleukin-1β maturation. Although the mutations in the PRY/SPRY domain of pyrin cause familial Mediterranean fever (FMF), the mechanism of how
Sei Samukawa +3 more
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El Tor Biotype Vibrio cholerae Activates the Caspase-11-Independent Canonical Nlrp3 and Pyrin Inflammasomes [PDF]
Frontiers in Immunology, 2019 Vibrio cholerae is a Gram-negative enteropathogen causing potentially life-threatening cholera disease outbreaks, for which the World Health Organization currently registers 2–4 million cases and ~100.000 cholera-associated deaths annually worldwide ...
Michail Mamantopoulos +14 more
doaj +3 more sources
MBio, 2023 Pyrin is a pattern-recognition receptor in phagocytes that triggers caspase-1 inflammasome assembly in response to bacterial toxins and effectors that inactivate RhoA.
Haleema S Malik +2 more
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The pyrin inflammasome, a leading actor in pediatric autoinflammatory diseases
Frontiers in ImmunologyThe activation of the pyrin inflammasome represents a highly intriguing mechanism employed by the innate immune system to effectively counteract pathogenic agents. Despite its key role in innate immunity, pyrin has also garnered significant attention due
Saverio La Bella +2 more
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Caspase-14-like Proteases: An Epidermal Caspase and Its Evolutionarily Ancient Relatives [PDF]
BiomoleculesCaspases are a family of cysteine-dependent aspartate-directed proteases implicated in programmed cell death. Humans have eleven proteolytically active caspases, namely caspase-1 through -10 and caspase-14.
Leopold Eckhart +3 more
doaj +2 more sources
CircCDC42-encoded CDC42-165aa regulates macrophage pyroptosis in Klebsiella pneumoniae infection through Pyrin inflammasome activation [PDF]
Nature CommunicationsThe circular RNA (circRNA) family is a group of endogenous non-coding RNAs (ncRNAs) that have critical functions in multiple physiological and pathological processes, including inflammation, cancer, and cardiovascular diseases.
Nana Xu +10 more
doaj +2 more sources
Update on Pyrin Functions and Mechanisms of Familial Mediterranean Fever
Frontiers in Microbiology, 2016 Mutations in the MEFV gene, which encodes the protein named pyrin (also called marenostrin or TRIM20), are associated with the autoinflammatory disease familial Mediterranean fever (FMF).
Gayane Manukyan, Rustam Aminov
exaly +3 more sources
Pyrin dephosphorylation is sufficient to trigger inflammasome activation in familial Mediterranean fever patients [PDF]
EMBO Molecular Medicine, 2019 Familial Mediterranean fever (FMF) is the most frequent hereditary systemic autoinflammatory syndrome. FMF is usually caused by biallelic mutations in the MEFV gene, encoding Pyrin.
Flora Magnotti +17 more
doaj +2 more sources