Results 1 to 10 of about 44,417 (236)
The Pyrin Inflammasome in Health and Disease [PDF]
Frontiers in Immunology, 2019 The pyrin inflammasome has evolved as an innate immune sensor to detect bacterial toxin-induced Rho guanosine triphosphatase (Rho GTPase)-inactivation, a process that is similar to the “guard” mechanism in plants. Rho GTPases act as molecular switches to
Oskar Schnappauf +2 more
exaly +6 more sources
Update on Pyrin Functions and Mechanisms of Familial Mediterranean Fever [PDF]
Frontiers in Microbiology, 2016 Mutations in the MEFV gene, which encodes the protein named pyrin (also called marenostrin or TRIM20), are associated with the autoinflammatory disease familial Mediterranean fever (FMF).
Gayane Manukyan +2 more
exaly +6 more sources
Pyrin Modulates the Intracellular Distribution of PSTPIP1. [PDF]
PLoS ONE, 2009 PSTPIP1 is a cytoskeleton-associated adaptor protein that links PEST-type phosphatases to their substrates. Mutations in PSTPIP1 cause PAPA syndrome (Pyogenic sterile Arthritis, Pyoderma gangrenosum, and Acne), an autoinflammatory disease.
Andrea L Waite +11 more
doaj +9 more sources
The pyrin inflammasome, a leading actor in pediatric autoinflammatory diseases
Frontiers in Immunology, 2023 The activation of the pyrin inflammasome represents a highly intriguing mechanism employed by the innate immune system to effectively counteract pathogenic agents. Despite its key role in innate immunity, pyrin has also garnered significant attention due
Saverio La Bella +2 more
exaly +4 more sources
Pyrin- and CARD-only Proteins as Regulators of NLR Functions [PDF]
Frontiers in Immunology, 2013 Upon activation Nod-like receptors (NLRs) assemble into multi-protein complexes such as the NODosome and inflammasome. This process relies upon homo-domain interactions between the structurally related Pyrin and caspase-recruitment (CARD) domains and ...
Hongnga T Le +2 more
exaly +5 more sources
Identification of Multifaceted Binding Modes for Pyrin and ASC Pyrin Domains Gives Insights into Pyrin Inflammasome Assembly [PDF]
Journal of Biological Chemistry, 2014 Inflammasomes are macromolecular complexes that mediate inflammatory and cell death responses to pathogens and cellular stress signals. Dysregulated inflammasome activation is associated with autoinflammatory syndromes and several common diseases. During inflammasome assembly, oligomerized cytosolic pattern recognition receptors recruit procaspase-1 ...
Vajjhala, Parimala R. +6 more
openaire +7 more sources
Function and mechanism of the pyrin inflammasome [PDF]
European Journal of Immunology, 2017 AbstractPyrin, encoded by the MEFV gene, is an intracellular pattern recognition receptor that assembles inflammasome complexes in response to pathogen infections. Mutations in the MEFV gene have been linked to autoinflammatory diseases such as familial Mediterranean fever (FMF) or pyrin‐associated autoinflammation with neutrophilic dermatosis (PAAND).
Rosalie Heilig, Petr Broz
openaire +5 more sources
Folding Pyrin into the Family [PDF]
Structure, 2003 AbstractThe first structure of a pyrin domain confirms its membership in the death domain superfamily, reveals a local unfolding of the third of six helices, and suggests that the folding/unfolding transition of this helix may be an important determinant of the function and disease related dysfunction of this domain.
David Eliezer, Eliezer, David
openaire +2 more sources
mBio, 2023 Pyrin is a pattern-recognition receptor in phagocytes that triggers caspase-1 inflammasome assembly in response to bacterial toxins and effectors that inactivate RhoA.
Haleema S. Malik +6 more
doaj +2 more sources
The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation. [PDF]
PLoS Pathogens, 2016 Type III secretion systems (T3SS) are central virulence factors for many pathogenic Gram-negative bacteria, and secreted T3SS effectors can block key aspects of host cell signaling.
Dmitry Ratner +12 more
doaj +4 more sources