Results 11 to 20 of about 83,545 (299)
CDC42 regulates PYRIN inflammasome assembly [PDF]
Cell Reports, 2022 The PYRIN inflammasome pathway is part of the innate immune response against invading pathogens. Unprovoked continuous activation of the PYRIN inflammasome drives autoinflammation and underlies several autoinflammatory diseases, including familial Mediterranean fever (FMF) syndrome.
Lotte Spel, Fabio Martinon
exaly +5 more sources
The Pyrin Inflammasome in Health and Disease [PDF]
Frontiers in Immunology, 2019 The pyrin inflammasome has evolved as an innate immune sensor to detect bacterial toxin-induced Rho guanosine triphosphatase (Rho GTPase)-inactivation, a process that is similar to the “guard” mechanism in plants. Rho GTPases act as molecular switches to
Oskar Schnappauf +2 more
exaly +5 more sources
Pyrin Modulates the Intracellular Distribution of PSTPIP1. [PDF]
PLoS ONE, 2009 PSTPIP1 is a cytoskeleton-associated adaptor protein that links PEST-type phosphatases to their substrates. Mutations in PSTPIP1 cause PAPA syndrome (Pyogenic sterile Arthritis, Pyoderma gangrenosum, and Acne), an autoinflammatory disease.
Andrea L Waite +11 more
doaj +6 more sources
Pyrin inflammasome-driven erosive arthritis caused by unprenylated RHO GTPase signaling [PDF]
EMBO Molecular MedicineGeranylgeranyl pyrophosphate, a non-sterol intermediate of the mevalonate pathway, serves as the substrate for protein geranylgeranylation, a process catalyzed by geranylgeranyl transferase I (GGTase-I).
Murali K Akula +12 more
doaj +2 more sources
The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation. [PDF]
PLoS Pathogens, 2016 Type III secretion systems (T3SS) are central virulence factors for many pathogenic Gram-negative bacteria, and secreted T3SS effectors can block key aspects of host cell signaling.
Dmitry Ratner +12 more
doaj +6 more sources
The PYRIN Domain in Signal Transduction [PDF]
Current Protein & Peptide Science, 2007 The Death Domain Fold superfamily of evolutionarily conserved protein-protein interaction domains consists of 4 subfamilies: the death domain, the death effector domain, the caspase recruitment domain, and the PYRIN domain. Interaction of Death Domain Fold containing proteins modulates the activity of several downstream effectors, such as caspases and ...
Christian Stehlik
openalex +4 more sources
PSTPIP1 and pyrin, two key regulators of macrophage differentiation
European Journal of Cell BiologyBackground: Monocytes develop from hematopoietic stem cells; migrate into the tissue, where they undergo a stimulation-dependent and tissue specific differentiation into macrophages imprinting specific inflammatory functions.
Philipp Berger +15 more
doaj +2 more sources
POPing the fire into the pyrin? [PDF]
Biochemical Journal, 2003 Initiation of an inflammatory response requires the co-ordinated participation of proteins within a scaffold in the cytosol of responding cells. The scaffold proteins contain members of a newly discovered family of pyrin-domain adaptor proteins that regulate complex assembly for initiation of nuclear factor κB and interleukin-1β signalling.
Sanjeev Mariathasan, Domagoj Vucic
openalex +4 more sources
Actin Remodeling Defects Leading to Autoinflammation and Immune Dysregulation
Frontiers in Immunology, 2021 A growing number of monogenic immune-mediated diseases have been related to genes involved in pathways of actin cytoskeleton remodeling. Increasing evidences associate cytoskeleton defects to autoinflammatory diseases and primary immunodeficiencies.
Riccardo Papa +3 more
doaj +1 more source
Frontiers in Immunology, 2023 BackgroundNeutrophil extracellular traps (NETs) can cause acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) by inducing macrophage pyroptosis.
Chenchen Liu +6 more
doaj +1 more source