Results 41 to 50 of about 35,163 (154)
Is there any relationship between human foamy virus infections and familial Mediterranean fever?
Journal of Research in Medical Sciences, 2018 Background: Familial Mediterranean fever (FMF) is generally defined as an autosomal recessive disease, characterized by the automatic activation of the innate immune system in the absence of a detectable pathogenic stimulant.
Melek Yuce, Hasan Bagci, Kuddusi Cengiz
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European Journal of Case Reports in Internal MedicineFamilial Mediterranean fever (FMF) is traditionally associated with biallelic mutations in the MEFV gene; however, heterozygous mutations may also contribute to disease phenotypes.
Marcus Villander Barros de Oliveira Sá +4 more
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Differential Binding of NLRP3 to non-oxidized and Ox-mtDNA mediates NLRP3 Inflammasome Activation
Communications Biology, 2023 The NLRP3 inflammasome is a key mediator of the innate immune response to sterile tissue injury and is involved in many chronic and acute diseases. Physically and chemically diverse agents activate the NLRP3 inflammasome.
Angela Cabral +8 more
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A HYPOTHETICAL ROLE FOR PLAGUE IN THE SELECTION OF MEFV MUTATION CARRIERS IN THE MEDITERRANEAN AREA
Central Asian Journal of Medical Hypotheses and Ethics, 2020 Familial Mediterranean fever (FMF) is the most common autoinflammatory disease associated with mutations in the MEFV gene encoding Pyrin. MEFV mutations are frequent in the Mediterranean region.
Ezgi Deniz Batu
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Activation Of The Pyrin Inflammasome By Intracellular Burkholderia Cenocepacia [PDF]
A35. RECENT ADVANCES IN PHAGOCYTE BIOLOGY, 2012 Abstract Burkholderia cenocepacia is an opportunistic pathogen that causes chronic infection and induces progressive respiratory inflammation in cystic fibrosis patients. Recognition of bacteria by mononuclear cells generally results in the activation of caspase-1 and processing of IL-1β, a major proinflammatory cytokine.
Mikhail A, Gavrilin +10 more
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Genetic loss of murine pyrin, the Familial Mediterranean Fever protein, increases interleukin-1β levels. [PDF]
PLoS ONE, 2012 Familial Mediterranean Fever (FMF) is an inherited autoinflammatory disorder characterized by unprovoked episodes of fever and inflammation. The associated gene, MEFV (Mediterranean Fever), is expressed primarily by cells of myeloid lineage and encodes ...
Pamela R Hesker +4 more
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Frontiers in Pharmacology, 2022 Radiation-induced enteropathy (RIE) is one of the most common and fatal complications of abdominal radiotherapy, with no effective interventions available.
Dong-ming Wu +20 more
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The pyrin inflammasome and the Yersinia effector interaction
Immunological Reviews, 2020 AbstractPyrin is a cytosolic pattern‐recognition receptor that normally functions as a guard to trigger capase‐1 inflammasome assembly in response to bacterial toxins and effectors that inactivate RhoA. The MEFV gene encoding human pyrin is preferentially expressed in phagocytes. Key domains in pyrin include a pyrin domain (PYD), a linker region, and a
Haleema S. Malik, James B. Bliska
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A dominant pathogenic MEFV mutation causes atypical pyrin-associated periodic syndromes
JCI Insight, 2023 Pyrin, a protein encoded by the MEFV gene, plays a vital role in innate immunity by sensing modifications in Rho GTPase and assembling the pyrin inflammasome, which in turn activates downstream immune responses.
Qintao Wang +6 more
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An updated view on the structure and function of PYRIN domains [PDF]
Apoptosis, 2014 The PYRIN domain (PYD) is a protein-protein interaction domain, which belongs to the death domain fold (DDF) superfamily. It is best known for its signaling function in innate immune responses and particularly in the assembly of inflammasomes, which are large protein complexes that allow the induced proximity-mediated activation of caspase-1 and ...
Lan Hoang, Chu +3 more
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