Results 41 to 50 of about 44,417 (236)

Let's get this pyrin started! [PDF]

Journal of Biological Chemistry, 2019
Inflammasomes enable cells to respond to pathogens or biological damage, but the specific signals being used to convey these messages are not always clear. A new paper identifies two potential microbiota-derived metabolites, the bile acid analogues BAA485 and BAA473, as the first small molecules to activate the pyrin inflammasome. These results suggest
Emilia Liana Falcone, Clare Bryant
openaire   +2 more sources

Increased Pyrin expression is required for Pyrin activation in human macrophages.

, 2022
(A) IL-1β release from LPS-primed (10 ng/ml, 3 or 18 h) hMDM were preincubated with compounds as noted previously, then stimulated with either TcdA (200 ng/ml), BAA-473 (10 μM), or (B) nigericin (8 μM) for 2.5 h.
Karoline Krause (345052), Florian I. Schmidt (9217080), Matthew S. J. Mangan (9295858), Ralf Gerhard (308579), Thomas Ebert (4055671), Karsten Hiller (9893), Marcus Maurer (224879), Friederike Gorki (14070539), Alexander Heinz (11718416), Anne Pankow (12959927), Veit Hornung (271019), Eicke Latz (416789), Dieter Jahn (9897)   +12 more
core   +1 more source

Is there any relationship between human foamy virus infections and familial Mediterranean fever?

Journal of Research in Medical Sciences, 2018
Background: Familial Mediterranean fever (FMF) is generally defined as an autosomal recessive disease, characterized by the automatic activation of the innate immune system in the absence of a detectable pathogenic stimulant.
Melek Yuce, Hasan Bagci, Kuddusi Cengiz
doaj   +1 more source

Über 4‐Ketoverbindungen der Pyrine [PDF]

Berichte der deutschen chemischen Gesellschaft, 1908
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Michaelis, A., Engelhardt, F.
openaire   +2 more sources

Bile acid analogues are activators of pyrin inflammasome [PDF]

Journal of Biological Chemistry, 2019
Bile acids are critical metabolites in the gastrointestinal tract and contribute to maintaining intestinal immune homeostasis through cross-talk with the gut microbiota. The conversion of bile acids by the gut microbiome is now recognized as a factor affecting both host metabolism and immune responses, but its physiological roles remain unclear.
Irina Alimov, Suchithra Menon, Nadire Cochran, Rob Maher, Qiong Wang, John Alford, John B. Concannon, Zinger Yang, Edmund Harrington, Luis Llamas, Alicia Lindeman, Gregory Hoffman, Tim Schuhmann, Carsten Russ, John Reece-Hoyes, Stephen M. Canham, Xinming Cai   +16 more
openaire   +2 more sources

Caspase-14-like Proteases: An Epidermal Caspase and Its Evolutionarily Ancient Relatives

Biomolecules
Caspases are a family of cysteine-dependent aspartate-directed proteases implicated in programmed cell death. Humans have eleven proteolytically active caspases, namely caspase-1 through -10 and caspase-14.
Leopold Eckhart, Attila Placido Sachslehner, Julia Steinbinder, Heinz Fischer   +3 more
doaj   +1 more source

El Tor Biotype Vibrio cholerae Activates the Caspase-11-Independent Canonical Nlrp3 and Pyrin Inflammasomes

Frontiers in Immunology, 2019
Vibrio cholerae is a Gram-negative enteropathogen causing potentially life-threatening cholera disease outbreaks, for which the World Health Organization currently registers 2–4 million cases and ~100.000 cholera-associated deaths annually worldwide ...
Michail Mamantopoulos, Michail Mamantopoulos, Ulrika C. Frising, Ulrika C. Frising, Tomoko Asaoka, Tomoko Asaoka, Geert van Loo, Geert van Loo, Geert van Loo, Mohamed Lamkanfi, Mohamed Lamkanfi, Andy Wullaert, Andy Wullaert, Andy Wullaert, Andy Wullaert   +14 more
doaj   +1 more source

Differential Binding of NLRP3 to non-oxidized and Ox-mtDNA mediates NLRP3 Inflammasome Activation

Communications Biology, 2023
The NLRP3 inflammasome is a key mediator of the innate immune response to sterile tissue injury and is involved in many chronic and acute diseases. Physically and chemically diverse agents activate the NLRP3 inflammasome.
Angela Cabral, Julia Elise Cabral, Angelina Wang, Yiyang Zhang, Hailin Liang, Donya Nikbakht, Leslie Corona, Hal M. Hoffman, Reginald McNulty   +8 more
doaj   +1 more source

Self‐Assembled Skin Equivalents with Monoclonal CRISPR/Cas9‐Modified N/TERT‐1 Keratinocytes: A Cutting‐Edge model for Human Skin and its Diseases

Advanced Healthcare Materials, EarlyView.
Self‐assembled, scaffold‐free full‐thickness skin equivalents with monoclonal, genetically modified N/TERT‐1 keratinocytes represent a novel in vitro model of human skin and skin diseases. The model is highly robust, reproducible, physiologically relevant, and suitable for high‐throughput applications.
Marta Slaufova, Tugay Karakaya, Michela Di Filippo, Thomas Kündig, Hans‐Dietmar Beer   +4 more
wiley   +1 more source

Francisella mediated inflammasome responses and cell injury is enhanced in absence of pyrin and reduced upon overexpression of Pyrin in PYRIN-KO/KI cells.

, 2018
A) CAS9, CAS9/PYRIN-KO and CAS9/PYRIN-KO/KI cells were stimulated with LPS (1μg/ml) for 2h or left untreated. Microparticulate p20 caspase-1 and p30 GSDM-D levels were analyzed.
Srabani Mitra (259173), Anasuya Sarkar (259171), Karthikeyan Krishnamurthy (5196806), Mark D. Wewers (94894), Erin Dolvin (6166652)   +4 more
core   +1 more source