Results 31 to 40 of about 44,417 (236)
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis
Hepatology, EarlyView., 2022 Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr +19 more
wiley +1 more source
Scientific Reports, 2021 Pyrin/TRIM20 is expressed in the neutrophils and monocytes/macrophages and regulates caspase-1 activation and interleukin-1β maturation. Although the mutations in the PRY/SPRY domain of pyrin cause familial Mediterranean fever (FMF), the mechanism of how
Sei Samukawa +3 more
doaj +1 more source
A dRAStic RHOAdblock of Pyrin inflammasome activation [PDF]
Nature Immunology, 2016 The Pyrin inflammasome guard is disabled if the activity of small cellular GTPase is compromised, in response to defects in the mevalonate pathway and directly by mutations in Pyrin, resulting in the IL-1β-driven autoinflammatory diseases MKD and FMF.
Andrea, Dorfleutner, Christian, Stehlik
openaire +2 more sources
Francisella recognition by inflammasomes: differences between Mice and Men
Frontiers in Cellular and Infection Microbiology, 2011 Pathogen recognition by intracellular sensors involves the assembly of a caspase-1 activation machine termed the inflammasome. Intracellular pathogens like Francisella that gain access to the cytosolic detection systems are useful tools to uncover the ...
Mikhail A Gavrilin, Mark D Wewers
doaj +1 more source
Familial Mediterranean Fever: Unraveling its Causes, Clinical presentation, and Innovative Treatment Strategies [PDF]
Archives of Pharmaceutical Sciences Ain Shams UniversityAuto-inflammatory disorders are recognized as significant in impacting the health of patients. The majority of auto-inflammatory disorders originate from hereditary abnormalities.
Abdelhamid, Ashraqat H. +10 more
doaj +1 more source
Genetics and Molecular Biology, 2017 The function of gene body DNA methylation in alternative splicing, and its relation to disease pathogenesis is not fully elucidated. The gene for familial Mediterranean fever (MEFV) encodes the pyrin protein and contains a 998 bp CpG island, covering the
Gokce Celikyapi Erdem +5 more
doaj +1 more source
The PYRIN Domain in Signal Transduction [PDF]
Current Protein & Peptide Science, 2007 The Death Domain Fold superfamily of evolutionarily conserved protein-protein interaction domains consists of 4 subfamilies: the death domain, the death effector domain, the caspase recruitment domain, and the PYRIN domain. Interaction of Death Domain Fold containing proteins modulates the activity of several downstream effectors, such as caspases and ...
openaire +2 more sources
The pyrin inflammasome in host–microbe interactions
Current Opinion in Microbiology, 2020 Pyrin is an inflammasome sensor in phagocytes that is activated in response to bacterial toxins and effectors that modify RhoA. Pathogen effector-triggered pyrin activation is analogous to an indirect guard mechanism in plants. Pyrin activation appears to be triggered when RhoA GTPases in a host cell are prevented from binding downstream signaling ...
Nicole A, Loeven +2 more
openaire +3 more sources
AA amyloidosis and pyrin gene mutations. [PDF]
Annals of Saudi Medicine, 2005 Konstantopoulos K +3 more
doaj +3 more sources