Results 61 to 70 of about 44,417 (236)

LPS, type I and type II interferons increase Pyrin expression and enable Pyrin activation in human macrophages.

, 2022
(A) Pyrin and IL-1β expression in hMDM treated with either IFN-γ (200 U/ml), LPS (10 ng/ml), TNFα (50 ng/ml), IL-10 (100 ng/ml), IFN-β (5,000 U/ml), IL-4 (1,000 U/ml), or Pam3CSK4 (20 ng/ml) for either 5 or 18 h.
Karoline Krause (345052), Florian I. Schmidt (9217080), Matthew S. J. Mangan (9295858), Ralf Gerhard (308579), Thomas Ebert (4055671), Karsten Hiller (9893), Marcus Maurer (224879), Friederike Gorki (14070539), Alexander Heinz (11718416), Anne Pankow (12959927), Veit Hornung (271019), Eicke Latz (416789), Dieter Jahn (9897)   +12 more
core   +1 more source

Activation Of The Pyrin Inflammasome By Intracellular Burkholderia Cenocepacia [PDF]

A35. RECENT ADVANCES IN PHAGOCYTE BIOLOGY, 2012
Abstract Burkholderia cenocepacia is an opportunistic pathogen that causes chronic infection and induces progressive respiratory inflammation in cystic fibrosis patients. Recognition of bacteria by mononuclear cells generally results in the activation of caspase-1 and processing of IL-1β, a major proinflammatory cytokine.
Mikhail A, Gavrilin, Dalia H A, Abdelaziz, Mahmoud, Mostafa, Basant A, Abdulrahman, Jaykumar, Grandhi, Anwari, Akhter, Arwa, Abu Khweek, Daniel F, Aubert, Miguel A, Valvano, Mark D, Wewers, Amal O, Amer   +10 more
openaire   +3 more sources

NIR‐II‐Trackable LYTACs Phyto‐Nanotheranostics for Source‐Microenvironment Dual‐Track ROS Regulation in Acute Gouty Arthritis

Advanced Science, EarlyView.
The TPR‐LYTACs nanomaterial offers a dual‐pathway strategy for precise gouty arthritis treatment by targeting and degrading the ROS‐producing enzyme NOX2 inside macrophages while its antioxidant core clears accumulated ROS outside. This “source inhibition and microenvironment scavenging” approach, guided by NIR‐II imaging, effectively controls local ...
Jian Zhang, Yingying Wang, Lujie Yu, Chunmei Jiang, Haoyu Liu, Yaohua Chen, Shutong Wu, Qin Liu, Lingling Wei, Xiaochun Zheng, Huifang Hao, Mengting Gao, Weiwei Kang, Rong Dai, Ziliang Zheng, Ruiping Zhang   +15 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Crystal structure and ligandability of the 14-3-3/pyrin interface [PDF]

, 2023
Overactivation of Pyrin is the cause of the inflammatory diseases Mediterranean Fever and Pyrin-associated autoinflammation with neutrophilic dermatosis (PAAND).
Lau, Roxanne, Ottmann, Christian, Hann, Michael M.   +2 more
core   +1 more source

A dominant pathogenic MEFV mutation causes atypical pyrin-associated periodic syndromes

JCI Insight, 2023
Pyrin, a protein encoded by the MEFV gene, plays a vital role in innate immunity by sensing modifications in Rho GTPase and assembling the pyrin inflammasome, which in turn activates downstream immune responses.
Qintao Wang, Taijie Jin, Shan Jian, Xu Han, Hongmei Song, Qing Zhou, Xiaomin Yu   +6 more
doaj   +1 more source

Phagocytic cell death leads to enhanced release of pro-inflammatory S100A12 in familial Mediterranean fever

Molecular and Cellular Pediatrics, 2023
Background Familial Mediterranean fever (FMF) is a prototypical autoinflammatory syndrome associated with phagocytic cell activation. Pyrin mutations are the genetic basis of this disease, and its expression has been shown in monocytes, granulocytes ...
G. Varga, S. Schleifenbaum, U. Koenig, J. Waldkirch, C. Hinze, C. Kessel, W. Geluk, T. Pap, Elke Lainka, Tilmann Kallinich, D. Foell, H. Wittkowski   +11 more
doaj   +1 more source

All‐Flex Plasma Patch for In Vivo Delivery of Reactive Species

Advanced Science, EarlyView.
A fully flexible plasma patch enables stable, conformal treatment on complex biological surfaces and enhances transdermal delivery of reactive species. This platform achieves significant tumor suppression in vivo and reveals coordinated regulation of calcium signaling, metabolism, and programmed cell death, providing a promising strategy for safe and ...
Luxiang Zhao, Abulaihaiti Tuergong, Hanshu Yang, Shuang Xue, An Yan, Mingzhen Wang, Weilong Song, Wenzhe Si, Ruixue Wang   +8 more
wiley   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Pyrin inflammasome and familial Mediterranean fever : deciphering the role of B30.2 and CHS in pyrin regulation

, 2022
L'inflammasome pyrine est activé en réponse à l'inhibition de RhoA par des pathogènes. La régulation de pyrine se déroule en deux étapes : la phosphorylation de pyrine par les kinases PKN1/2, eux-mêmes des effecteurs de RhoA, et une deuxième étape liée à
Chirita, Daria
core