Results 61 to 70 of about 35,163 (154)

Autoinflammatory diseases. Part 2. Pyrin inflammasomopathies and other enhanced interleukin 1 signaling syndromes

Zdorovʹe Rebenka
Systemic autoinflammatory diseases (SAIDs) are considered dysregulation disorders of the innate immune system characterized by systemic sterile inflammation independent of infection and autoreactive antibodies or antigen-specific T cells ...
О.В. Шварацька, Т.А. Бордій, К.К. Годяцька, М.В. Калічевська, О.В. Клименко, О.М. Таран, О.В. Клімова, Я.В. Віленський   +7 more
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Pyrin dephosphorylation is sufficient to trigger inflammasome activation in familial Mediterranean fever patients

EMBO Molecular Medicine, 2019
Familial Mediterranean fever (FMF) is the most frequent hereditary systemic autoinflammatory syndrome. FMF is usually caused by biallelic mutations in the MEFV gene, encoding Pyrin.
Flora Magnotti, Lucie Lefeuvre, Sarah Benezech, Tiphaine Malsot, Louis Waeckel, Amandine Martin, Sébastien Kerever, Daria Chirita, Marine Desjonqueres, Agnès Duquesne, Mathieu Gerfaud‐Valentin, Audrey Laurent, Pascal Sève, Michel‐Robert Popoff, Thierry Walzer, Alexandre Belot, Yvan Jamilloux, Thomas Henry   +17 more
doaj   +1 more source

Three-dimensional structure of the NLRP7 pyrin domain: insight into pyrin-pyrin-mediated effector domain signaling in innate immunity.

The Journal of biological chemistry, 2010
The innate immune system provides an initial line of defense against infection. Nucleotide-binding domain- and leucine-rich repeat-containing protein (NLR or (NOD-like)) receptors play a critical role in the innate immune response by surveying the cytoplasm for traces of intracellular invaders and endogenous stress signals.
Anderson S, Pinheiro, Martina, Proell, Clarissa, Eibl, Rebecca, Page, Robert, Schwarzenbacher, Wolfgang, Peti   +5 more
openaire   +1 more source

Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells.

PLoS Pathogens, 2020
Members of the family of pyrin and HIN domain containing (PYHIN) proteins play an emerging role in innate immunity. While absent in melanoma 2 (AIM2) acts a cytosolic sensor of non-self DNA and plays a key role in inflammasome assembly, the γ-interferon ...
Matteo Bosso, Caterina Prelli Bozzo, Dominik Hotter, Meta Volcic, Christina M Stürzel, Annika Rammelt, Yi Ni, Stephan Urban, Miriam Becker, Mario Schelhaas, Sabine Wittmann, Maria H Christensen, Florian I Schmidt, Thomas Gramberg, Konstantin M J Sparrer, Daniel Sauter, Frank Kirchhoff   +16 more
doaj   +1 more source

A Novel Mutation in the Pyrin Domain of the NOD-like Receptor Family Pyrin Domain Containing Protein 3 in Muckle-Wells Syndrome

Chinese Medical Journal, 2017
Background: Cryopyrin-associated periodic syndrome (CAPS) is a group of rare, heterogeneous autoinflammatory disease characterized by interleukin (IL)-1β-mediated systemic inflammation and clinical symptoms involving skin, joints, central nervous system,
Jian Hu, Yun Zhu, Jian-Zhong Zhang, Rong-Guang Zhang, Hou-Min Li   +4 more
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Mycobacterium tuberculosis does not inhibit NLRP1 and pyrin inflammasomes in human macrophages

Microbiology Spectrum
Mycobacterium tuberculosis (Mtb) has been known to evade host innate immunity by manipulating macrophage function. Interleukin-1β (IL-1β) is a cytokine secreted by macrophages as a consequence of inflammasome activation. Mtb can inhibit activation of the
Akshaya Ganesh, Shivangi Rastogi, Volker Briken   +2 more
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MCC950 suppresses NLRP3-dependent neuroinflammation and ameliorates cognitive decline in a rat model of cerebral small vessel disease

Neural Regeneration Research
Cerebral small vessel disease is a major vascular contributor to cognitive impairment and dementia. However, there remains a lack of effective preventative or therapeutic regimens for cerebral small vessel disease.
Meiyan Zhang, Xiaoyan Lan, Yue Gao, Shen Li, Guanda Qiao, Yajie Liang, Miroslaw Janowski, Piotr Walczak, Chengyan Chu   +8 more
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CircCDC42-encoded CDC42-165aa regulates macrophage pyroptosis in Klebsiella pneumoniae infection through Pyrin inflammasome activation

Nature Communications
The circular RNA (circRNA) family is a group of endogenous non-coding RNAs (ncRNAs) that have critical functions in multiple physiological and pathological processes, including inflammation, cancer, and cardiovascular diseases.
Nana Xu, Jiebang Jiang, Fei Jiang, Guokai Dong, Li Meng, Meng Wang, Jing Chen, Cong Li, Yongping Shi, Sisi He, Rongpeng Li   +10 more
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Kolşisinin pyrin ve pyrin ile ilişkili proteinler üzerine etkisi

, 2012
Taşkıran ZE. Kolşisinin Pyrin ve Pyrin ile İlişkili Proteinler Üzerine Etkisi. Hacettepe Üniversitesi, Sağlık Bilimleri Enstitüsü, Tıbbi Biyoloji Doktora Tezi, Ankara, 2012. Otoinflamatuvar hastalıklar içinde en yaygın olanı ailevi Akdeniz ateşidir (AAA).
openaire   +2 more sources

A plasmonic biosensor pre-diagnostic tool for Familial Mediterranean Fever

Nature Communications
Familial Mediterranean Fever (FMF) is an autosomal recessive genetic disorder, primarily observed in populations around the Mediterranean Sea, linked to MEFV gene mutations.
Idil Karaca Acari, Fatma Kurul, Meryem Beyza Avci, S. Deniz Yasar, Seda Nur Topkaya, Ceyhun Açarı, Erbil Ünsal, Balahan Makay, Süleyman Köytepe, Burhan Ateş, İsmet Yilmaz, Turgay Seçkin, Arif E. Cetin   +12 more
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