Results 81 to 90 of about 701,729 (307)

The properties of Msh2-Msh6 ATP binding mutants suggest a signal amplification mechanism in DNA mismatch repair. [PDF]

, 2018
DNA mismatch repair (MMR) corrects mispaired DNA bases and small insertion/deletion loops generated by DNA replication errors. After binding a mispair, the eukaryotic mispair recognition complex Msh2-Msh6 binds ATP in both of its nucleotide-binding sites,
Graham, William J, Kolodner, Richard D, Putnam, Christopher D   +2 more
core  

Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons. [PDF]

, 2017
Increased α-synuclein (αsyn) and mitochondrial dysfunction play central roles in the pathogenesis of Parkinson's disease (PD), and lowering αsyn is under intensive investigation as a therapeutic strategy for PD. Increased αsyn levels disrupt mitochondria
Bendor, Jacob T, Berthet, Amandine, Edwards, Robert H, Manfredsson, Fredric P, Nakamura, Ken, Nguyen, Mai K, Orr, Adam L, Pathak, Divya, Sellnow, Rhyomi C, Yu, Katharine   +9 more
core   +1 more source

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

The Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose, Nicolae Radu, Mugurel Constantin Rusu   +2 more
wiley   +1 more source

CT attenuation analysis of carotid intraplaque hemorrhage [PDF]

, 2018
Background and Purpose: Intraplaque hemorrhage is considered a leading parameter of carotid plaque vulnerability. Our purpose was to assess the CT characteristics of intraplaque hemorrhage with histopathologic correlation to identify features that allow ...
Bassareo, P. P., Cecco, C. N. D., Faa, X. G., Francone, M., Lai, L., Montisci, R., Saba, L., Sanfilippo, Rosa, Suri, J. S.   +8 more
core   +1 more source

Tranexamic Acid Use in Hip Arthroscopy Reduces Bleeding Without Increased Risk of Major Complications: A Systematic Review

Arthroscopy, EarlyView.
Purpose To critically evaluate the impact of tranexamic acid (TXA) on hip arthroscopy outcomes, including its effects on bleeding, functional recovery, postoperative pain, complications, intraoperative visualization, and surgical efficiency. Methods A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic ...
Paul B. Walker, Mathangi Sridharan, Adrian Lin, Atousa Nourmahnad, Alexander Fish, Sharon L. Hame, Kristofer J. Jones   +6 more
wiley   +1 more source

Partial Repair and Superior Capsular Reconstruction Both Improve Outcomes for Irreparable Posterosuperior Rotator Cuff Tears: A Systematic Review

Arthroscopy, EarlyView.
Purpose To synthesize patient‐reported outcome measures, failure rates, and mobility parameters for comparison of partial repair versus superior capsular reconstruction (SCR) in the treatment of irreparable posterosuperior rotator cuff tears. Methods EMBASE, OVID Medline, and Emcare were searched from database inception to November 2024 for studies on ...
Marc Daniel Bouchard, Cameron Pow, Matthew Macciacchera, Vanay Verma, Tinghua Zhang, Bogdan Matache   +5 more
wiley   +1 more source

Preoperative Resilience Does Not Predict Functional Outcomes After Rotator Cuff Repair: A Systematic Review

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To determine whether preoperative or concurrent resilience is related to postoperative functional outcomes after arthroscopic rotator cuff repair (aRCR). Methods A literature search was conducted from PubMed, SportDiscus, and OVID Medline databases to identify studies evaluating the effect of preoperative resilience on postoperative outcomes in
Paxton Sweeney, Nzubechukwu (Joshua) Obidike, Ryan W. Paul, Jordan T. Windsor, Francis J. Sirch, Fotios P. Tjoumakaris, Kevin B. Freedman   +6 more
wiley   +1 more source

Outcomes reported in trials of children and adolescent knee injuries: a systematic review

Bone & Joint Open
Aims: To systematically review published evidence of outcomes reported in trials of knee injuries in children and adolescents. Methods: We searched the following databases from inception to 29 July 2024: OVID MEDLINE, Embase, Cochrane CENTRAL ...
Ignatius Liew, Wen Xian Low, Adeel Ikram, Stephen McDonnell, Ben Arthur Marson, Core Kids Knee Steering committee   +5 more
doaj   +1 more source

Face and Construct Validity of a Grapefruit Arthroscopy Training Model With Active Fluid Management

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To evaluate the face and construct validity of a grapefruit arthroscopy training model with active fluid management across varying levels of arthroscopic experience. Methods Orthopaedic residents, fellows, and attending surgeons were stratified into novice (n = 10), intermediate (n = 10), and advanced (n = 9) groups.
Harrison A. Volaski, Christopher Perrino, Yungtai Lo, Michael Hossack, Benjamin J. Levy, I. Martin Levy   +5 more
wiley   +1 more source

Association Between Body Mass Index and Mortality in Patients With Tuberculosis-HIV Co-Infection in Asia and Africa

Al-Sihah: The Public Health Science Journal
Globally, the prevalence of tuberculosis (TB) and human immunodeficiency virus (HIV) co-infection in 2019 was 8.2%. In 2020, TB-related deaths among individuals with HIV totaled 214,000, representing an increase from the previous year.
Mufti As Siddiq M. Irzal, Tri Yunis Miko Wahyono, Putri Novia Choiri Insani, Welstin Wemi Loa, Leopardo Alvalius Ngetwa   +4 more
doaj   +1 more source