Results 41 to 50 of about 125,156 (180)

Treatment of medullary thyroid cancer with bone metastases with denosumab: A review and case illustration

Journal of Clinical and Translational Endocrinology Case Reports, 2020
Bone Metastases are frequently reported in neuroendocrine tumors, including medullary thyroid carcinoma. The optimal management of these lesions, which can lead to serious skeletal-related events, including hypercalcemia, bone pain, fractures, and spinal
Leslie S. Eldeiry, Han-Ting Lin
doaj   +1 more source

Flexible Integration of Structurally Diverse Spatial Multi‐Omics With AgaeSMO

Advanced Science, EarlyView.
AgaeSMO is a versatile and robust deep learning framework for flexible cross‐integration of spatial multi‐omics data. Leveraging a GATs network with a graph attention module, it learns joint embedding across diverse modalities, enabling integration of both structurally paired (e.g., spatial transcriptome‐epigenome, transcriptome‐proteome, transcriptome‐
Kunpeng Liu, Jinpo Su, Haotian Zhou, Yilin Shen, Mengke Qin, Yingjie Luo, Tiancai Wang, Zhenglin Chen, Yuanyuan Wang, Xiaokai Ma   +9 more
wiley   +1 more source

Occult medullary breast carcinoma in a male

Formosan Journal of Surgery, 2018
Occult breast cancer (OBC) or breast cancer presenting without an evident primary tumor is a rare presentation and can lead to a diagnostic dilemma. Further, the treatment of OBC is a subject of much controversy.
Devesh Sanjeev Ballal, Gabriel Rodrigues
doaj   +1 more source

SynAtlas: A Safe and Versatile Platform for Rapid Organ‐Scale Tissue Clearing and 3D Atlas Mapping

Advanced Science, EarlyView.
An orthogonal synergy design principle integrates lipid solubilization, protein hydration modulation, and refractive‐index matching within a unified aqueous clearing system. This modular strategy enables rapid, low‐hazard, and broadly compatible tissue clearing while preserving molecular signals, supporting multiscale three‐dimensional imaging across ...
Mei‐Xue Yuan, Xin‐Ya Qin, Ling‐Jie Li, Kai‐Lang Xiao, Meng‐Meng Zhang, Kun‐Qi Chen, Peng Chen, Yu Wang, Chen‐Wei Wang, Nan Zhou, Qing‐Hong Shan   +10 more
wiley   +1 more source

Recurrent Neurodevelopmental Disorder Associated With a Dominant‐Negative TOP2B H63Y Variant

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT We describe a 7 year‐old boy with severe neurodevelopmental disorder, medically‐refractory epileptic encephalopathy, hyperkinetic movement disorder, hypotonia, cerebral and cerebellar atrophy and hypomyelination who was found to have a heterozygous de novo TOP2B NM_001330700.2:c.187C>T, p.(His63Tyr) variant.
Zong Yi Ha, Leticia Dinatto, Kirsten Meagher, Colleen Guimond, Jan M. Friedman, Peter C. Stirling, Millan S. Patel   +6 more
wiley   +1 more source

Local variation in age‐related cortical expansion within and between cross‐sections of distal human long bones

The Anatomical Record, EarlyView.
Abstract Cortical bone expansion is an age‐related process where, through endosteal resorption and periosteal apposition, cross‐sectional diameter increases while cortical thickness decreases in long bone diaphyses. Local variation has been observed in this process between cross‐sectional locations, but few studies have examined directional variation ...
Gregory J. Wehrman, Alice F. Gooding, Adam D. Sylvester, Dawnie W. Steadman, Benjamin M. Auerbach   +4 more
wiley   +1 more source

Colonic Medullary Carcinoma: A Rare Case

İstanbul Medical Journal, 2017
Medullary carcinoma is a rare subtype of colorectal cancer making up less than 0.1% of all colorectal malignancies. This subtype can be confused with poorly differentiated colorectal carcinoma due to undifferentiated complexion morphology and high ...
Halis Bağ, Haldun Kar, Necat Cin, Arzu Avcı, Yasin Peker, Evren Durak   +5 more
doaj   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad, Anshu Arora, Arun Arora, Jeena Vaid, Arif Khan   +4 more
wiley   +1 more source

Safety outcomes of antidiabetic medications: A comprehensive review of the EU summaries of product characteristics and international clinical practice guidelines

British Journal of Clinical Pharmacology, EarlyView.
Aims Information on the safety profile of antidiabetic medications is essential for informed treatment decisions in type 2 diabetes mellitus. Although this information is available in regulatory documents of individual drugs, a comprehensive overview across all approved antidiabetics is lacking.
David Liang, Daniala L. Weir, Safana Thevasahayam, Vera H. M. Deneer, Arno Siebes, Helga Gardarsdottir   +5 more
wiley   +1 more source