Results 51 to 60 of about 3,167,167 (225)

Treatment of medullary thyroid cancer with bone metastases with denosumab: A review and case illustration

Journal of Clinical and Translational Endocrinology Case Reports, 2020
Bone Metastases are frequently reported in neuroendocrine tumors, including medullary thyroid carcinoma. The optimal management of these lesions, which can lead to serious skeletal-related events, including hypercalcemia, bone pain, fractures, and spinal
Leslie S. Eldeiry, Han-Ting Lin
doaj   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Functional role of the CXCR4 chemokine receptor in thyroid cancer [PDF]

, 2009
Thyroid cancer is the most common endocrine malignancy and its incidence is increasing worldwide. We previously found that normal rat thyroid cells, transduced with papillary thyroid cancer (PTC)-related oncogenes, display an inflammatory signature, that
Avilla, Elvira
core   +1 more source

Effect of Vandetanib Treatment on Cystic Changes in the Liver following Metastasis from Medullary Thyroid Carcinoma

Case Reports in Endocrinology, 2022
A number of causes are responsible for the development of cystic lesions in the liver. However, metastasis is a rare cause, and cystic metastasis from medullary thyroid carcinoma has not yet been reported.
Ai Matsui, Soji Toda, Daisuke Murayama, Hiroyuki Iwasaki   +3 more
doaj   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer [PDF]

, 2009
Background: Thyroid nodules are a common clinical problem, and differentiated thyroid cancer is becoming increasingly prevalent. Since the publication of the American Thyroid Association's guidelines for the management of these disorders was published in
Steward DL, Tuttle RM, Schlumberger M, Martin Schlumberger, Stephanie L. Lee, Haugen, Bryan R., McIver B, Cooper, David S., Haugen BR, Cooper DS, American Thyroid Association Guidelines Taskforce on Thyroid Nodules, Mandel, Susan J., Steward, David L., Bryan McIver, Richard T. Kloos, Mazzaferri EL, Steven I. Sherman, Doherty, Gerard M., Sherman, Steven I., Susan J. Mandel, Lee SL, Kloos RT, R. Michael Tuttle, McIver, Bryan, Ernest L. Mazzaferri, Kloos, Richard T., Lee, Stephanie L., Gerard M. Doherty, Pacini, Furio, Doherty GM, Bryan R. Haugen, Schlumberger, Martin, Furio Pacini, Differentiated Thyroid Cancer, David S. Cooper, Mazzaferri, Ernest L., Mandel SJ, Sherman SI, David L. Steward, Tuttle, R. Michael   +39 more
core   +1 more source

Medullary thyroid carcinoma with double negative calcitonin and CEA: a case report and update of literature review

BMC Endocrine Disorders, 2019
Background Medullary thyroid carcinoma is a malignant uncommon and aggressive tumour of the parafollicular C cells. In about 75% of cases it is sporadic while, in case of RET mutation, it is associated to multiple endocrine neoplasia type 2 (25% of cases)
Claudio Gambardella, Chiara Offi, Guglielmo Clarizia, Roberto Maria Romano, Immacolata Cozzolino, Marco Montella, Rosa Maria Di Crescenzo, Massimo Mascolo, Angelo Cangiano, Sergio Di Martino, Giancarlo Candela, Giovanni Docimo   +11 more
doaj   +1 more source

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad, Anshu Arora, Arun Arora, Jeena Vaid, Arif Khan   +4 more
wiley   +1 more source

RMRP, RMST, FTX and IPW: novel potential long non-coding RNAs in medullary thyroid cancer

Orphanet Journal of Rare Diseases, 2021
The relevant role of long non-coding RNAs (lncRNAs) in cancer is currently a matter of increasing interest. Medullary thyroid cancer (MTC) is a rare neuroendocrine tumor (2–5% of all thyroid cancer) derived from the parafollicular C-cells which secrete ...
Berta Luzón-Toro, Leticia Villalba-Benito, Raquel María Fernández, Ana Torroglosa, Guillermo Antiñolo, Salud Borrego   +5 more
doaj   +1 more source

Safety outcomes of antidiabetic medications: A comprehensive review of the EU summaries of product characteristics and international clinical practice guidelines

British Journal of Clinical Pharmacology, EarlyView.
Aims Information on the safety profile of antidiabetic medications is essential for informed treatment decisions in type 2 diabetes mellitus. Although this information is available in regulatory documents of individual drugs, a comprehensive overview across all approved antidiabetics is lacking.
David Liang, Daniala L. Weir, Safana Thevasahayam, Vera H. M. Deneer, Arno Siebes, Helga Gardarsdottir   +5 more
wiley   +1 more source