Results 91 to 100 of about 747,425 (295)

Meeting report: Signal transduction meets systems biology

open access: yesCell Communication and Signaling, 2012
In the 21st century, systems-wide analyses of biological processes are getting more and more realistic. Especially for the in depth analysis of signal transduction pathways and networks, various approaches of systems biology are now successfully used ...
Louis-Dit-Sully Christine   +5 more
doaj   +1 more source

Interim Science Council (TAC) Eighty-Second Meeting, April 8 - 12, 2002 : Draft Report of the Meeting

open access: yes, 2002
Report of TAC 82 (interim Science Counci) held at CIP, Lima, Peru, April 8-12, 2002, Emil Javier presiding. Chairman Ian Johnson addressed the meeting by via video conference.
CGIAR Interim Science Council
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Technical Advisory Committee Seventy-Eighth Meeting, 27-31 March 2000: Report of the Meeting

open access: yes, 2000
Report of TAC 78 held at the World Bank in Paris, March 27-31, 2000, Emil Javier presiding. The draft report was approved without change at TAC 79. The Committee debated with stakeholders present the first version of a new vision and strategy for the ...
CGIAR Technical Advisory Committee
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Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Report of the ... ordinary general meeting, subscription list and balance sheets.

open access: yes
Reports 2nd-79th also form 6th-83th of: Egypt Exploration Society. Report of annual general meeting, subscription list, and balance sheet.Mode of access: Internet.Vols.
Egypt Exploration Society.
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Technical Advisory Committee Sixty-Fifth Meeting, 18-22 October 1994: Report of the Meeting

open access: yes, 1995
Report of TAC 65 held at IFPRI, Washington D.C., October 17-22, 1995, Alex McCalla presiding. Ismail Serageldin, Chairman of the CGIAR, informed TAC about MTM94, and the agenda for ICW94. He said TAC would play a major role in a restructured CGIAR.
CGIAR Technical Advisory Committee
core  

Report of the Second Meeting of the CGIAR Oversight Committee [PDF]

open access: yes, 1993
Report of the second meeting of the CGIAR Oversight Committee held in Washington in October 21-22, and 25, 1993 before and during International Centers Week, Paul Egger presiding.
CGIAR Oversight Committee
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