Results 51 to 60 of about 4,982 (197)

The Effect of Uridine Diphosphate‐Glucuronosyltransferase Inhibition on the Pharmacokinetics of Ecopipam and Its Metabolites

open access: yesClinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Ecopipam, a selective dopamine D1 receptor antagonist in development for Tourette syndrome, is primarily converted by uridine diphosphate‐glucuronosyltransferase (UGT)1A9 to ecopipam glucuronide, with a minor metabolic pathway by cytochrome P450 3A4 forming EBS‐101‐40853 (also referred to as N‐desmethylecopipam or SCH 40853; also ...
Virginia D. Schmith   +3 more
wiley   +1 more source

Crystallization of mefenamic acid and polymorphs

open access: yes, 2008
The crystallization of Mefenamic Acid, (MA), which has a prevalent usage in drug formulation, was investigated. MA is a high-dose, anti-inflammatory, analgesic agent used for pain in menstrual disorders.
Gokbel S., Cesur S.
core   +1 more source

Comparative Study of Chitosan and Carboxy Methyl Chitosan Nanoparticles in Mefenamic Acid Drug Delivery

open access: yes, 2020
Nanoparticle based technologies improve the efficiency and speed of already existing processes.The larger size materials and reagents which are in reactive form, can be nanosized to give efficient output.
Vedavahini, Parankusham, Sailu, Chintha
core   +1 more source

Flexible Crystals, Polymorph Selection and Interface Engineering for Organic Electronics: How New Discoveries and Established Knowledge Can Provide New Stimuli for Research Into Organic Semiconducting Single Crystals

open access: yesAdvanced Electronic Materials, Volume 12, Issue 1, 7 January 2026.
This work reviews recent advances in Organic Semiconducting Single Crystals (OSSCs), focusing on mechanical flexibility for robust devices, polymorph control for precise phase selection, and interface engineering with self‐assembled monolayers to improve alignment and performance.
Alessando Fraleoni‐Morgera   +3 more
wiley   +1 more source

Novel colorimetric assay of mefenamic acid using 4-amino-3,5-dinitrobenzoic acid (ADBA)

open access: yes, 2002
Purpose: To develop a novel colorimetric assay method for mefenamic acid capsules. Method: The new method (aromatic ring derivatization technique) is based on a diazo coupling reaction using diazotized 4-amino-3,5-dinitrobenzoic acid (ADBA) as a ...
Idowu, SO   +7 more
core   +1 more source

Nonsteroidal Anti‐Inflammatory Drugs and Risk of Gastrointestinal Bleeding: A Systematic Review and Meta‐Analysis

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 46-62, January 2026.
Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely used for pain and inflammation but are associated with gastrointestinal (GI) bleeding. While this risk is well established, most studies evaluate NSAIDs as a homogenous class, limiting clinical decision‐making based on individual agent safety.
Abdelrahman G. Tawfik   +7 more
wiley   +1 more source

Towards Safer Water: A Low‐Cost Disposable Electrochemical Sensor for Bisphenol A Using La2Sn2O7 Nanostructures

open access: yesGlobal Challenges, Volume 10, Issue 1, January 2026.
A highly sensitive electrochemical sensor featuring lanthanum stannate nanomaterial is introduced for the rapid detection of bisphenol A (BPA) in water. The sensor delivers fast response, excellent selectivity, and ultra‐low detection limits, enabling reliable monitoring of BPA in real environmental samples.
Ragu Sasikumar   +4 more
wiley   +1 more source

An investigation of the neuropharmacological and behavioural effects of fenamate and other NSAIDs. [PDF]

open access: yes, 2001
Recent evidence has indicated that NSAIDs might have direct effects on CNS tissue in addition to their classical inhibitory action on COX enzymes. This thesis addresses this hypothesis using electrophysiological and behavioural techniques. The effects of
Foxon, Graham Ronald
core  

ANALYTICAL APPLICATIONS OF MEFENAMIC ACID BY HYDROTROPE APPROACH: TITRIMETRIC ESTIMATION AND ULTRAVIOLET METHOD VALIDATION

open access: yes, 2021
Objectives: Mefenamic acid is used as a modal nonsteroidal anti-inflammatory drug for analytical estimation. Due to the poor aqueous solubility, mefenamic acid liberated reduced bioavailability.
TRIPATHI, DEVIKA   +2 more
core  

Safety Assessment of Repeated Oral Administration of Tolfenamic Acid in Japanese Quails: Haematological, Biochemical and Histopathological Evaluations

open access: yesVeterinary Medicine and Science, Volume 12, Issue 1, January 2026.
Safety of tolfenamic acid in Japanese quails. ABSTRACT Objective This study evaluated the safety profile of tolfenamic acid following repeated oral administration in Japanese quails (Coturnix coturnix japonica) at doses of 2 and 8 mg/kg every 12 h for 7 days. Methods The 42 quails were randomly assigned to three groups. The first group (n = 6) received
Fatih Hatipoglu   +6 more
wiley   +1 more source

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