Results 1 to 10 of about 6,939 (203)

Genetic and Epigenetic Regulation of MEFV Gene and Their Impact on Clinical Outcome in Auto-Inflammatory Familial Mediterranean Fever Patients [PDF]

Current Issues in Molecular Biology, 2023
Epigenetic modifications play a pivotal role in autoimmune/inflammatory disorders and could establish a bridge between personalized medicine and disease epidemiological contexts.
May E. Zekry, Al-Aliaa M. Sallam, Sherihan G. AbdelHamid, Waheba A. Zarouk, Hala T. El-Bassyouni, Hala O. El-Mesallamy   +5 more
doaj   +4 more sources

Frequencies of the MEFV Gene Mutations in Azerbaijan [PDF]

Balkan Journal of Medical Genetics, 2022
The MEFV (familial Mediterranean fever gene) researches were performed in the population of the Republic of Azerbaijan in 2016–2021. Seven mutations of the MEFV gene were identified in heterozygous, homozygous and compound homozygous conditions: R761H ...
Huseynova LS, Mammadova SN, Aliyeva KAA
doaj   +4 more sources

Recurrent synovitis of hip and MEFV gene related arthritis in children [PDF]

Pediatric Rheumatology Online Journal, 2020
Background Recurrent and relapsing arthritis has been proposed to describe a group of arthritis with recurring and periodic nature, in which the joints are intermittently involved.
Farhad Salehzadeh, Mehrdad Mirzarahimi
doaj   +6 more sources

MEFV gene mutation distrubution in Azerbaijan population [PDF]

Pediatr Rheumatol Online J, 2015
Familial Mediterranean fever (FMF)(MIM 249100) is a hereditary autoinflammatory disorder characterized by episodes of inflammation in the absence of high-titer autoantibodies or antigen-specific T cells. The Mediterranean fever (MEFV) gene(OMIM 608107) located on chromosome 16p13.3, which encodes the 781-amino-acid protein pyrin, is the causative gene ...
Berdeli A, Mukhtarova G, Oz A, Musayev S.   +3 more
europepmc   +4 more sources

Repeated Necrotizing Lymphadenitis with MEFV Gene Mutations. [PDF]

Intern Med, 2022
We herein report a 36-year-old man with repeated necrotizing lymphadenitis due to MEFV gene mutations. The patient's chief complaints were a fever and painful cervical lymphadenopathy. We diagnosed him with necrotizing lymphadenitis based on the pathological findings of the lymph nodes and the exclusion of other differential diseases.
Yamamura Y, Furuichi K, Toyama T, Oshima M, Ogura H, Sato K, Nakagawa S, Miyagawa T, Kitajima S, Hara A, Iwata Y, Sakai N, Shimizu M, Ikeda H, Toma T, Takasawa K, Yachie A, Wada T.   +17 more
europepmc   +3 more sources

Prediction of More Severe MEFV Gene Mutations in Childhood. [PDF]

Turk Arch Pediatr, 2021
This study aimed to present the demographic, clinical, and laboratory features of children clinically diagnosed with familial Mediterranean fever (FMF) and to predict more severe mutations by evaluating those findings.We enrolled cases diagnosed with FMF with a defined variation in at least one allele.
Güneş-Yılmaz S, Kasap-Demir B, Soyaltın E, Erfidan G, Özdemir-Şimşek Ö, Arslansoyu-Çamlar S, Alaygut D, Mutlubaş F.   +7 more
europepmc   +4 more sources

Evaluation of the Clinical Effects and Frequency of MEFV Gene Mutation in Patients with Inflammatory Bowel Disease [PDF]

Gastroenterology Research and Practice, 2021
Background. The clinical and pathological features of inflammatory bowel disease (IBD) and Familial Mediterranean Fever (FMF) are similar. Objective. Here, the frequency of Mediterranean Fever (MEFV) gene mutation and its effect on the outcome of IBD ...
S. Sahin, D. Gulec, S. Günay, C. Cekic
doaj   +2 more sources

MEFV gene mutations in neuro‐Behçet's disease and neuro‐Sweet disease [PDF]

Annals of Clinical and Translational Neurology, 2019
Mediterranean fever (MEFV) gene mutations are associated with familial Mediterranean fever (FMF). Recent studies have suggested that MEFV gene mutations may act as disease modifiers in neuro‐Behçet's (NBD) disease and neuro‐Sweet disease (NSD).
Hidehiro Ishikawa, Akihiro Shindo, Yuichiro Ii, Dai Kishida, Atsushi Niwa, Yamato Nishiguchi, Keita Matsuura, Natsuko Kato, Akane Mizutani, Kei Tachibana, Yoshinori Hirata, Hirofumi Matsuyama, Ai Ogawa‐Ito, Akira Taniguchi, Hidekazu Tomimoto   +14 more
doaj   +2 more sources

The role of MEFV gene in COVID 19 disease, as a protective factor [PDF]

Balkan Journal of Medical Genetics, 2020
Abstract Atypical clinical forms of familial Mediterranean fever (FMF) can be misdiagnosed as therapy-resistant epigastric pain syndrome (EPS) for they share many of the same clinical features, such as abdominal pain. Thus, we aimed to determined the frequency of FMF in patients who were followed with a diagnosis of therapy-resistant EPS.
Salehzadeh F, Shahbazifar E, Pourfarzi F, Molatefi R, Davarnia B, Ahmadabadi F.   +5 more
europepmc   +6 more sources

MEFV gene variations in COVID-19 pneumonia patients (Pilot study). [PDF]

J Genet Eng Biotechnol
The emergence of worldwide pandemic caused by coronavirus 2 (SARS-CoV-2) has caused a radical change in everyday life. Patients diseased with FMF show manifestations and labs highly similar to COVID infected patients. In the current study, we evaluate the presence of variants in exon 10 of MEFV gene and the relation with severity of symptoms in ...
Radwan NA, Gohary HE, Hamed D, Khalil NM, Abdelfatah D, Wahab AA, Elsharkawy MM.   +6 more
europepmc   +4 more sources