Results 31 to 40 of about 2,516,978 (116)

A HYPOTHETICAL ROLE FOR PLAGUE IN THE SELECTION OF MEFV MUTATION CARRIERS IN THE MEDITERRANEAN AREA

Central Asian Journal of Medical Hypotheses and Ethics, 2020
Familial Mediterranean fever (FMF) is the most common autoinflammatory disease associated with mutations in the MEFV gene encoding Pyrin. MEFV mutations are frequent in the Mediterranean region.
Ezgi Deniz Batu
doaj   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, Volume 293, Issue 18, Page 5481-5513, September 2026.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

Exploratory Analysis of the Inhibitory Effects of Propranolol on NLRP3 and Pyrin Inflammasomes

ACR Open Rheumatology, Volume 8, Issue 8, August 2026.
Objective Propranolol, a nonselective beta receptor blocking agents, impacts cAMP levels and is commonly used to treat hypertension and hemangioma in children and adults. Although there are reports indicating its anti‐inflammatory properties, the exact mechanism is not fully understood. Methods Murine and human monocytes and macrophages were exposed to
Renske J. de Jong, Christopher T. Neullens, Aljoscha Swoboda, Melanie Saers, Philipp Berger, Sudheendra Hebbar Subramanyam, Anastasia Wiener, Kim Ohl, Ralf Weiskirchen, Heidi Noels, Tilmann Kallinich, Julia Guthrie, Christoph Kessel, Klaus Tenbrock   +13 more
wiley   +1 more source

Evaluation of Familial Mediterranean Fever Patients in Sivas in Terms of MEFV Gene Mutations

, 2023
Objective: Familial Mediterranean Fever is an autosomal recessive autoinflammatory multisystemic genetic disease caused by mutations in the MEFV gene.
Abdussamed Yasin DEMİR, Demir, Abdussamed Yasin, Ömer YAKAR, Yakar, Ömer   +3 more
core   +1 more source

MEFV gene analysis in PFAPA

, 2003
The PFAPA syndrome is a chronic disease of unknown etiology characterized by Periodic episodes of high Fever accompanied by Aphthous stomatitis, Pharyngitis, and cervical Adenitis, sometimes associated with headache and/ or abdominal or joint pain.
Hentgen, Véronique, Cazeneuve, Cécile, Hau, Isabelle, Reinert, Philippe, Geneviève, David, Amselem, Serge   +5 more
core   +1 more source

The effects of epigenetic regulation on phenotypic expressivity in Turkish patients with familial Mediterranean fever

Indian Journal of Rheumatology, 2019
Introduction: In this study, we aimed to characterize the effect of methylation on clinical diversity and gene expression levels in familial Mediterranean fever.
Eser Dogan, Semra Gursoy, Giray Bozkaya, Secil Arslansoyu Camlar, Ozge Aksel Kilicarslan, Alper Soylu, Ayfer Ulgenalp, Salih Kavukcu, Ozlem Giray Bozkaya   +8 more
doaj   +1 more source

Course of COVID-19 in patients carrying different MEFV mutations of familial Mediterranean fever

Medicine Science
Familial Mediterranean Fever (FMF) is a genetic auto-inflammatory disease. Mutations in the Mediterranean fever (MEFV) gene cause inappropriate immune system triggering, leading to inflammatory episodes in the peritoneum, pleura, and joints.
Bilgehan Demir, Dogu Karahan
doaj   +1 more source

MEFV gene mutations in Henoch- Schonlein purpura

, 2013
ensari, arzu/0000-0001-7036-4457AimCoexistence of familial Mediterranean fever (FMF) with various systemic vasculitides, including Henoch-Schonlein purpura (HSP) and other inflammatory disorders has been reported and the MEFV gene has been suggested to ...
Ensari, Arzu, Derya B. Sayin, Ensari, Cuneyt, Umut Altug, Arzu Ensari, Sayin, Derya B., Altug, Umut, Cuneyt Ensari   +7 more
core   +1 more source

The Multifaceted Role of Pyroptosis: Molecular Mechanisms, Crosstalk with Other Cell Death Pathways, and Therapeutic Implications

MedComm, Volume 7, Issue 7, July 2026.
Pyroptosis maintains immune homeostasis by eliminating damaged or infected cells, but its dysregulation promotes inflammation and cancer progression. The diagram illustrates key activation pathways, links with other programmed cell deaths, and cancer‐specific effects, enhancing its dual protective and pathogenic roles.
Diego Liviu Boaru, Patricia De Castro‐Martinez, Cielo Garcia‐Montero, Oscar Fraile‐Martinez, Majd N. Michael Alhaddadin, Silvestra Barrena‐Blázquez, Laura Lopez‐Gonzalez, Clara Tasende Fernández, Ricardo Alvarado‐Hurtado, Tomás Ratia Giménez, Inmaculada Lasa‐Unzúe, Manuel Díez Alonso, Alberto Gutiérrez‐Calvo, Miguel A. Saez, David Cobo‐Prieto, Jose V. Saz, Melchor Alvarez‐Mon, Raul Diaz‐Pedrero, Miguel A. Ortega   +18 more
wiley   +1 more source

Frequencies of the MEFV Gene Mutations in Azerbaijan

Balkan Journal of Medical Genetics, 2022
The MEFV (familial Mediterranean fever gene) researches were performed in the population of the Republic of Azerbaijan in 2016–2021. Seven mutations of the MEFV gene were identified in heterozygous, homozygous and compound homozygous conditions: R761H ...
Huseynova LS, Mammadova SN, Aliyeva KAA
doaj   +1 more source