Results 51 to 60 of about 4,057 (128)

Evaluation of the Effect of IL‐1 Antagonists on Pituitary Function

International Journal of Endocrinology, Volume 2026, Issue 1, 2026.
Background Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disease frequently observed in populations along the Eastern Mediterranean coast, characterized by recurrent fever, abdominal pain, and joint inflammation. The disease results from mutations in the MEFV gene, which plays a critical role in regulating IL‐1β secretion ...
Fadime Aktas Koc, Baris Sariakcali, Ali Sahin, Vikas Kumar Roy   +3 more
wiley   +1 more source

Development and External Validation of a Genetic Risk Score for Pain in Rheumatoid Arthritis

Arthritis Care &Research, Volume 77, Issue 12, Page 1409-1417, December 2025.
Objective Several single‐nucleotide polymorphisms (SNPs) have been associated with chronic pain syndromes. Our objective was to determine whether genetic variants are associated with pain and disease activity in rheumatoid arthritis (RA). Methods Participants were included from two independent RA cohorts: FORWARD (National Databank for Rheumatic ...
Katie J. McMenamin, Thomas R. Riley IV, Kristin Wipfler, Kaleb Michaud, Austin Wheeler, Bryant R. England, Brian Sauer, Katherine D. Wysham, Rui Xiao, Michael March, Grant W. Cannon, Sylvanus Toikumo, Henry R. Kranzler, Rachel L. Kember, Ted R. Mikuls, Joshua F. Baker   +15 more
wiley   +1 more source

A molecular analysis of familial Mediterranean fever disease in a cohort of Turkish patients

Annals of Saudi Medicine, 2012
BACKGROUND AND OBJECTIVES: Familial Mediterranean fever (FMF) is an autosomal recessive disorder caused by mutations in MEFV gene, which encodes pyrin. FMF is especially prevalent among Turks, Armenians, non-Ashkenazi Jews, and Arabs.
Munis Dundar, Aslihan Kiraz, Elif Funda Emirogullari, Çetin Saatci, Serpil Taheri, Mevlut Baskol, Seher Polat, Yusuf Özkul   +7 more
doaj   +1 more source

Inflammation and genetics in myo‐pericardial diseases: Insights from the Italian Study Group on Cardiomyopathies and Pericardial Diseases

ESC Heart Failure, Volume 12, Issue 6, Page 3987-3999, December 2025.
Proposed management of myo‐pericardial diseases. A systematic interdisciplinary approach to myo‐pericardial disease is essential to reach a correct diagnosis, starting from multiparametric characterization including EKG, echocardiography with GLS, laboratory exams and CMR or, in case of electric or haemodynamic instability, EMB.
Marco Merlo, Giulia Bassetto, Antonio Cannatà, Alberto Aimo, Camillo Autore, Barbara Bauce, Elena Biagini, Francesco Cappelli, Silvia Castelletti, Flavio D'Ascenzi, Cesare de Gregorio, Giuseppe Limongelli, Francesca Marzo, Beatrice Musumeci, Giacomo Tini, Roberto Pedrinelli, Pasquale Perrone Filardi, Gianfranco Sinagra, Massimo Imazio   +18 more
wiley   +1 more source

Limited association of MEFV gene variants with disease severity and clinical phenotypes in children with MIS-C

Egyptian Pediatric Association Gazette
Background Multisystem inflammatory syndrome in children (MIS-C) is a post-infectious hyperinflammatory condition that develops after SARS-CoV-2 infection and may involve multiple organ systems, including the cardiovascular, hematologic, neurologic, and ...
Hala Lotfy, Heba Atef, Fatma Abd El Wahab, Sarah Ragab, Hend Abu Shady   +4 more
doaj   +1 more source

Concomitance of Familial Mediterranean Fever and Gitelman syndrome in an adolescent

The Turkish Journal of Pediatrics, 2019
Gitelman syndrome is a renal tubular salt-wasting disorder characterized by hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria. Patients occasionally have symptoms in childhood, while diagnosis is often in adulthood.
Bahriye Atmış, Rabia Miray Kışla-Ekinci, Engin Melek, Atıl Bişgin, Mustafa Yılmaz, Ali Anarat, Aysun Karabay-Bayazıt   +6 more
doaj   +1 more source

Impact of Mediterranean Fever Gene Mutations on Clinical Characteristics in Patients With Inflammatory Bowel Disease

Gastro Hep Advances
Background and Aims: The Mediterranean fever (MEFV) gene, which encodes a pyrin protein, is the causative gene of familial Mediterranean fever. Patients with inflammatory bowel disease (IBD) have a significantly higher frequency of MEFV mutations than ...
Tomoya Nakamura, Kohei Wagatsuma, Yuki Hayashi, Hiromu Morikubo, Daisuke Saito, Masashi Idogawa, Masanori Nojima, Jun Miyoshi, Minoru Matsuura, Tadakazu Hisamatsu, Hiroshi Nakase   +10 more
doaj   +1 more source

The MEFV gene pathogenic variants and phenotype-genotype correlation in children with familial Mediterranean fever in the Çanakkale population

Balkan Journal of Medical Genetics, 2016
The aim of the current study was to determine the frequency of the Mediterranean fever (MEFV) gene pathogenic variants in 60 children diagnosed with familial Mediterranean fever (FMF) and to compare the phenotype-genotype correlation.
Battal F, Silan F, Topaloğlu N, Aylanç H, Yıldırım Ş, Köksal Binnetoğlu F, Tekin M, Kaymaz N, Ozdemir O   +8 more
doaj   +1 more source

Kawasaki disease and familial mediterranean fever gene mutations, is there any link?

Open Access Rheumatology: Research and Reviews, 2019
Farhad Salehzadeh,1 Mehrdad Mirzarahimi,2 Saied Hosseini Asl,3 Roghayeh Nematdoust Haghi41Pediatric Rheumatology, Pediatric Department, Bouali Children’s Hospital, Ardabil University of Medical Sciences (ARUMS), Ardabil, Iran; 2Pediatric, Pediatric
Salehzadeh F, Mirzarahimi M, Hosseini Asl S, Nematdoust Haghi R   +3 more
doaj  

Involvement of Mediterranean fever gene mutations in colchicine-responsive enterocolitis: a retrospective cohort studyResearch in context

EBioMedicine
Summary: Background: The involvement of Mediterranean fever (MEFV) gene mutations in patients with inflammatory bowel disease unclassified (IBDU) remains unclear.
Hiroshi Nakase, Kohei Wagatsuma, Taku Kobayashi, Takayuki Matsumoto, Motohiro Esaki, Kenji Watanabe, Reiko Kunisaki, Teruyuki Takeda, Katsuhiro Arai, Takashi Ibuka, Dai Ishikawa, Yuichi Matsuno, Hirotake Sakuraba, Nobuhiro Ueno, Kaoru Yokoyama, Masayuki Saruta, Ryota Hokari, Junji Yokoyama, Shu Tamano, Masanori Nojima, Tadakazu Hisamatsu, Shusaku Yoshikawa, Sohachi Nanjo, Akira Andoh, Takeshi Kimura, Makoto Ooi, Ryosuke Kiyomori, Nobuo Aoyama, Fumihito Hirai, Atsushi Yamaushi, Masanao Nakamura, Fumikazu Koyama, Shuhei Hosomi, Kazuki Kakimoto, Satoshi Motoya, Ryosuke Sakemi, Hideo Suzuki, Tadashi Hosoya, Ken Takeuchi, Manabu Shiraki, Hideyuki Koide, Ichiro Takeuchi, Yosuke Furui, Kento Yoshida, Ayaka Minemura, Asami Matsumoto, Kentaro Oka   +46 more
doaj   +1 more source