Results 71 to 80 of about 6,939 (203)

A Brain‐Targeting Curcumin Analog Inhibits Glioblastoma Progression Through THBS1/TGF‐β1/PI3K–AKT Axis Modulation: Evidence From Experimental and Bioinformatic Analyses

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT Glioblastoma (GBM) is the most aggressive primary brain tumour, associated with a dismal prognosis and an urgent need for innovative therapeutic strategies. To address this challenge, our group developed DMC‐GF, a novel brain‐targeted curcumin analog engineered to enhance blood–brain barrier permeability by blocking metabolic sites and ...
Zijian Han, Xuetao Li, Yang Zhu, Zhimin Wang, Yingbo Hou, Huiling Tao, Meng Ma, Xiangtong Xie, HaiYang Zhang   +8 more
wiley   +1 more source

Analysis of the mutations in exon 10 of MEFV gene in patients with premature coronary heart disease in west Azerbaijan province of Iran [PDF]

Journal of Cardiovascular and Thoracic Research, 2018
Introduction: Premature coronary heart disease (PCHD) affects public health and leads to death. PCHD has several genetic and environmental risk factors. The aim of this study was to analysis of the mutations in exon 10 of MEFV gene in patients with PCHD ...
Morteza Bagheri, Kamal Khadem-Vatani, Mir Hossein Seyed Mohammad Zad, Isa Abdi Rad, Behzad Rahimi, Alireza Rostamzadeh, Mojtaba Godarzi, Shabnam Ashena   +7 more
doaj   +1 more source

M694V gene polymorphism may not contribute to the pathogenesis of reactive arthritis in the North Indian population

Indian Journal of Rheumatology, 2023
Introduction: Reactive arthritis (ReA) is a postinfectious, nonseptic arthritis that is characterized by an acute lower limb predominant oligoarthritis.
Anamika Kumari Anuja, Koshy Nitin Thomas, Mantabya Kumar Singh, Ashish Jacob Mathew, Vikas Agarwal, Latika Gupta   +5 more
doaj   +1 more source

Exploring Diagnostic Challenges: A Case Report Commentary on “Solving a Diagnostic Dilemma in a Patient With Periodic Fever—When the Pieces of the Puzzle Finally Fit” [PDF]

Clin Case Rep
ABSTRACT This case highlights the diagnostic challenge of distinguishing periodic fever syndromes with prominent neurological features from interferonopathies. While the absence of specific features on MRI/MRA and SAVI reduces the likelihood of certain subtypes, genetic evaluation involving interferon pathway genes remains important.
Kelesoglu F, Polat A.
europepmc   +2 more sources

Future perspective for diagnosis in autoimmune diseases [PDF]

, 2009
Human beings have taken successive approaches for the understanding and management of diseases. Initially brewed in supernatural concepts and mystical procedures, a vigorous scientific approach has emerged on the grounds of fundamental disciplines such ...
Andrade, Luiz Eduardo Coelho
core   +3 more sources

TNF Inhibitor Therapy in Corticosteroid‐Resistant or ‐Dependent Pediatric Neutrophilic Dermatosis

Pediatric Dermatology, Volume 43, Issue 2, Page 373-377, March/April 2026.
ABSTRACT Neutrophilic dermatoses are rare in children. Systemic corticosteroids are the first‐line treatment, but guidelines for second‐line therapies are lacking. We report five cases of children with systemic steroid‐resistant/dependent neutrophilic dermatoses, successfully treated with tumor necrosis factor inhibitors.
Laure Chêne, Thomas Hubiche, Jean‐Marie De Guillebon, Maella Severino‐Freire, Emmanuelle Bourrat, Sébastien Barbarot, Alice Phan, Christine Chiaverini   +7 more
wiley   +1 more source

Construction of an ~700-kb transcript map around the Familial Mediterranean Fever locus on human chromosome 16p13.3 [PDF]

, 1998
We used a combination of cDNA selection, exon amplification, and computational prediction from genomic sequence to isolate transcribed sequences from genomic DNA surrounding the familial Mediterranean fever (FMF) locus.
Adams, Aksentijevich, Andrea Cercek, Anil Vedula, Antequera, Buckland, Calabro, Chen, Dahl, Daniel L. Kastner, Darrell O. Ricke, David F. Callen, David Krizman, Deborah Gumucio, Elizabeth Mansfield, Francis S. Collins, Geryl Wood, Huebner, Ivona Aksentijevich, Jingmei Liu, Kulp, Lancet, Melanie Hamon, Michael Centola, Nathan Fischel-Ghodsian, Neil Richards, Neta Shafran, Norman A. Doggett, Nurit Zaks, P. Paul Liu, Pras, Puder, Raman Sood, Robert I. Richards, Robert K. Moyzis, Sinoula Apostolou, Tanaz Kahan, Trevor Blake, Xiang Chen, Xiaoguang Chen, Yasuda, Yokoyama, Zuoming Deng   +42 more
core   +1 more source

Schnitzler Syndrome as an Autoinflammatory Disease Driven by B‐Cell‐Specific Somatic MYD88 Mutation

Allergy, EarlyView.
Yuyi Zhou, Yoko Ueki, Naoya Iwata, Hiroshi Oue, Kentaro Kato, Mengyan Li, Kazushi Izawa, Tomoyasu Jo, Seishi Ogawa, Kenji Kabashima, Naotomo Kambe   +10 more
wiley   +1 more source

Obesity‐Associated TRIM15 Promotes the Proliferation of Esophageal Adenocarcinoma Through the YY2/FOXRED1 Axis

Advanced Science, Volume 13, Issue 4, 19 January 2026.
The study identifies TRIM15 as a key driver in the development of obesity‐associated esophageal adenocarcinoma (EAC). Mechanistically, TRIM15 degrades YY2 through the proteasome pathway, suppressing FOXRED1 transcription and ultimately accelerating tumor proliferation.
Haohui Wang, Chong Yang, Dayuan Luo, Pingting Liu, Zhen Zeng, Weilin Peng, Dongzi Peng, Hao Su, Xiaoxiong Xiao, Haiqin Wang, Xin Jin   +10 more
wiley   +1 more source

Multiple Myeloma in a Patient With Familial Mediterranean Fever [PDF]

, 2017
Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by recurrent episodes of painful inflammation in the abdomen, chest, or joints. The coexistence of multiple myeloma (MM) and FMF is an extremely rare event.
Bashardoust, Bahman, Maleki, Nasrollah
core