Results 81 to 90 of about 6,939 (203)

Evaluation of the Effect of IL‐1 Antagonists on Pituitary Function

International Journal of Endocrinology, Volume 2026, Issue 1, 2026.
Background Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disease frequently observed in populations along the Eastern Mediterranean coast, characterized by recurrent fever, abdominal pain, and joint inflammation. The disease results from mutations in the MEFV gene, which plays a critical role in regulating IL‐1β secretion ...
Fadime Aktas Koc, Baris Sariakcali, Ali Sahin, Vikas Kumar Roy   +3 more
wiley   +1 more source

Familial Mediterranean fever in Armenian children with inflammatory bowel disease

Frontiers in Pediatrics
Inflammatory bowel disease (IBD) and familial Mediterranean fever (FMF) are inflammatory diseases with complex interactions among genetic, immune, and environmental factors.
Gayane Amaryan, Gayane Amaryan, Tamara Sarkisian, Tamara Sarkisian, Artashes Tadevosyan, Christian Braegger   +5 more
doaj   +1 more source

Autoimmune-autoinflammatory rheumatoid arthritis overlaps: a rare but potentially important subgroup of diseases [PDF]

, 2017
At the population level, rheumatoid arthritis (RA) is generally viewed as autoimmune in nature with a small subgroup of cases having a palindromic form or systemic autoinflammatory disorder (SAID) phenotype.
Barcenas-Morales, G, Doffinger, R, Emery, P, McGonagle, D, Mistry, A, Savic, S, Wilson, AG   +6 more
core   +1 more source

Development and External Validation of a Genetic Risk Score for Pain in Rheumatoid Arthritis

Arthritis Care &Research, Volume 77, Issue 12, Page 1409-1417, December 2025.
Objective Several single‐nucleotide polymorphisms (SNPs) have been associated with chronic pain syndromes. Our objective was to determine whether genetic variants are associated with pain and disease activity in rheumatoid arthritis (RA). Methods Participants were included from two independent RA cohorts: FORWARD (National Databank for Rheumatic ...
Katie J. McMenamin, Thomas R. Riley IV, Kristin Wipfler, Kaleb Michaud, Austin Wheeler, Bryant R. England, Brian Sauer, Katherine D. Wysham, Rui Xiao, Michael March, Grant W. Cannon, Sylvanus Toikumo, Henry R. Kranzler, Rachel L. Kember, Ted R. Mikuls, Joshua F. Baker   +15 more
wiley   +1 more source

Inflammation and genetics in myo‐pericardial diseases: Insights from the Italian Study Group on Cardiomyopathies and Pericardial Diseases

ESC Heart Failure, Volume 12, Issue 6, Page 3987-3999, December 2025.
Proposed management of myo‐pericardial diseases. A systematic interdisciplinary approach to myo‐pericardial disease is essential to reach a correct diagnosis, starting from multiparametric characterization including EKG, echocardiography with GLS, laboratory exams and CMR or, in case of electric or haemodynamic instability, EMB.
Marco Merlo, Giulia Bassetto, Antonio Cannatà, Alberto Aimo, Camillo Autore, Barbara Bauce, Elena Biagini, Francesco Cappelli, Silvia Castelletti, Flavio D'Ascenzi, Cesare de Gregorio, Giuseppe Limongelli, Francesca Marzo, Beatrice Musumeci, Giacomo Tini, Roberto Pedrinelli, Pasquale Perrone Filardi, Gianfranco Sinagra, Massimo Imazio   +18 more
wiley   +1 more source

STING inhibition alleviates experimental peritoneal damage: potential therapeutic relevance for peritoneal dialysis

The Journal of Pathology, Volume 267, Issue 2, Page 196-212, October 2025.
Abstract Peritoneal dialysis (PD) is a widely used kidney replacement therapy for patients with end‐stage kidney disease. Nevertheless, long‐term exposure to PD fluid can damage the peritoneal membrane, leading to ultrafiltration failure and, ultimately, discontinuation of PD.
Vanessa Marchant, Jorge García‐Giménez, Guadalupe T González‐Mateo, Pilar Sandoval, Lucía Tejedor‐Santamaria, Sandra Rayego‐Mateos, Ricardo Ramos, José A Jiménez‐Heffernan, Alberto Ortiz, Anne‐Catherine Raby, Manuel López‐Cabrera, Adrián M Ramos, Marta Ruiz‐Ortega   +12 more
wiley   +1 more source

MEFV gene mutation analysis in patient with PFAPA [PDF]

Introduction : syndrome PFAPA (periodic fever, aphthous mouth, pharyngitis and adenitis) is a clinical syndrome that usually occur in children younger than 5 years.
حسینی اصل, سید سعید, صالح زاده, فرهاد, واحدی نمین, مریم   +2 more
core   +1 more source

IgA Vasculitis Across the Ages: Is It Time for a Precision Medicine Approach?

ACR Open Rheumatology, Volume 7, Issue 9, September 2025.
IgA vasculitis (IgAV; formerly Henoch‐Schönlein purpura) is a systemic small vessel vasculitis most commonly affecting the skin, gut, joints, and kidneys. Nephritis is the most concerning complication for all ages because it carries the risk of progression to irreversible end‐stage kidney failure.
A. Gage, R. J. Pepper, J. Marro, A. D. Salama, L. Oni   +4 more
wiley   +1 more source

MEFV gen mutation analysis in patient with idiopatic uveitis [PDF]

Introduction : FMF is an autosomal recessive disease that have high prevalence in the Mediterranean region. Common Clinical findings in FMF included abdominal pain, fever, arthritis, myalgia and pleuritis.
صالح زاده, فرهاد, پیری, نیلوفر, یثربی, سیده عذرا   +2 more
core   +1 more source

Distribution of MEFV gene mutations and R202Q polymorphism in the Serbian population and their influence on oxidative stress and clinical manifestations of inflammation [PDF]

, 2016
BACKGROUND: The Mediterranean fever (MEFV) gene codes for protein pyrin, one of the regulators of inflammasome activity in innate immune cells. Mutations in this gene are considered the primary cause of Familial Mediterranean fever, but are also found in
Andrej Veljković, Dragana Lazarević, Dušica Pavlović, Gordana Kocić, Jelena Milenković, Jelena Vojinović, Maja Milojković, Maruša Debeljak, Nataša Toplak, Tadej Avčin, Tatjana Jevtović-Stoimenov, Vladmila Bojanić   +11 more
core   +1 more source