Results 21 to 30 of about 5,045 (167)

Outcome of Toxic Megacolon during Pregnancy

Canadian Journal of Gastroenterology, 1990
Two patients with ulcerative colitis required subtotal colectomy and ileostomy for toxic megacolon during pregnancy. Subsequently, a mucosal proctectomy with ileal pouch-anal anastomosis was performed. These two patients who avoided permanent ileostomies
Carl Chartrand-Lefebvre, Jacques Heppell, Claude Potvin, Richard Clermont, Alfons Pomp   +4 more
doaj   +1 more source

Toxic megacolon associated with Clostridium difficile infection recurrence: a case report complicated by multiple bacterial infections and successfully treated with oral fidaxomicin

Clinical Management Issues, 2014
Toxic megacolon is a severe complication of Clostridium difficile infection (CDI) with a high percentage of mortality. The mainstay of treatment is currently represented by medical management, while surgical intervention is indicated in patients not ...
Addolorata Masiello, Mario Magliocca, Giuseppina Dell’Aquila, Patrizia Maio, Sergio Giglio, Nicola Acone   +5 more
doaj   +1 more source

Rectal endometriosis presenting as toxic megacolon

Autopsy and Case Reports, 2021
Background: The bowel is the most common site of extragenital endometriosis, with involvement of the locoregional sigmoid colon and anterior rectum seen most often.
Luis Enrique Rosario Alvarado, Hisham Bahmad, Odille Mejia, Heather Hollembeak, Robert Poppiti, Lydia Howard, Kiranmayi Muddasani   +6 more
doaj  

Severe Clostridium difficile infections in intensive care units: Diverse clinical presentations

Journal of Microbiology, Immunology and Infection, 2021
Background: Clostridium difficile infections (CDIs) cause significant mortality and morbidity. Critically ill patients are susceptible to CDIs and tend to have severe CDIs, and their clinical presentations are not merely diarrhea.
Jen-Chieh Lee, Yuan-Pin Hung, Bo-Yang Tsai, Pei-Jane Tsai, Wen-Chien Ko   +4 more
doaj   +1 more source

Rectal stump management in paediatric ulcerative colitis—An international survey for the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition PORTO Inflammatory Bowel Disease group study

JPGN Reports, EarlyView.
Abstract Objective To evaluate current international clinical practice in the assessment and management of rectal stump disease activity following colectomy in paediatric ulcerative colitis (UC). Methods A web‐based survey comprising 18 questions was distributed to paediatric gastroenterologists via European Porto inflammatory bowel disease (IBD ...
Beth Gordon, Sarah Cooper, Billy Bourke, Séamus Hussey   +3 more
wiley   +1 more source

Pediatric Clostridiodes difficile infection with toxic megacolon successfully treated with fecal microbiota transplantation

JPGN Reports, EarlyView.
Abstract The rising incidence of pediatric Clostridioides difficile infection (CDI), particularly in medically complex patients, calls for novel, individualized treatments. While fecal microbiota transplantation (FMT) is well‐described for recurrent CDI, this report describes the first pediatric case of fulminant CDI with toxic megacolon successfully ...
Dana McCarney, Pamela Chen, Jenna Simes, Stacy A. Kahn   +3 more
wiley   +1 more source

Lowering the C‐Reactive Protein (CRP) Threshold Improves Risk Stratification in Acute Ulcerative Colitis: A Propensity‐Matched Analysis

Alimentary Pharmacology &Therapeutics, EarlyView.
In 503 acute UC admissions, colectomy risk was equivalent between TWC‐positive ASUC and NASUC inpatients after propensity score matching for objective disease severity and treatment exposure; lowering the CRP threshold to ≥ 12 mg/L reclassified 26% of NASUC cases as ASUC and captured 43% of those requiring colectomy within one year, improving ...
Amirah Etchegaray, Naeman Goetz, Katherine Hanigan, Jennifer Phillips, Rina Kumar, George Tambakis, Graham Radford‐Smith, Gareth Walker, Anthony Croft   +8 more
wiley   +1 more source

Review Article: Immune Effector Cell‐Mediated Enterocolitis Following CAR‐T Cell Therapy—Clinical Features, Pathophysiology and Management

Alimentary Pharmacology &Therapeutics, EarlyView.
Immune effector cell‐mediated enterocolitis is an emerging complication of CAR‐T therapy. This review summarizes its epidemiology, pathophysiology, diagnosis, endoscopic and histopathologic features, and evidence‐based management, emphasizing early recognition, multidisciplinary intervention, and step‐up therapy.
John A. Damianos, Yi Lin, Zongming Eric Chen, Kenneth J. C. Lim, Navreet M. Chowla   +4 more
wiley   +1 more source

A Case of Toxic Megacolon Caused by Clostridium difficile Infection and Treated with Fecal Microbiota Transplantation

Gut and Liver, 2015
Toxic megacolon is a rare clinical complication of fulminant Clostridium difficile infection. The mortality rate of fulminant C. difficile infection is reported to be as high as 50%.
doaj   +1 more source

Blowhole Colostomy for Clostridium difficile-Associated Toxic Megacolon

Case Reports in Surgery, 2016
We present the case of a 58-year-old man who underwent urgent blowhole colostomy for toxic megacolon (TM) secondary to Clostridium difficile infection (CDI).
Jeroen Kerstens, Ian Diebels, Charles de Gheldere, Patrick Vanclooster   +3 more
doaj   +1 more source