Results 41 to 50 of about 5,495 (201)
Toxic Megacolon leading to bowel perforation: A rare adverse effect of bortezomib
, 2023 Bortezomib is a chemotherapeutic drug used in the treatment of multiple myeloma and amyloidosis. The major dose-limiting adverse effect is neuropathy. Although rare, autonomic involvement of the gastrointestinal tract, can present with ileus. We report a
Sitaraman, Karthikeyan +3 more
core +1 more source
British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2162-2170, July 2026.Aims Ocrelizumab is a humanized anti‐CD20 monoclonal antibody used in multiple sclerosis. Since its commercialization, several cases of ocrelizumab‐induced colitis have been reported in the scientific literature. Methods To explore the potential association of ocrelizumab with colitis as an adverse drug reaction (ADR), we conducted a descriptive and ...
Audrey Fresse +3 more
wiley +1 more source
JCC Plus, Volume 1, Issue 4, July 2026.Overall, patients with IBD constituted 1.6% (n = 37) of all admissions to the gastroenterology ward for any indication. Most (2/3rd) hospitalized patients with IBD responded to conventional therapy; one third required advanced therapy or surgery. In‐hospital mortality was high at 5%, probably related to delayed diagnosis, limited access to advanced ...
Ajay Kumar Yadav +5 more
wiley +1 more source
, 2017 The main therapeutic basis for a case of organophosphate poisoning is a combination therapy which includes atropine as an anticholinergic drug and pralidoxime.
Babak Mostafazadeh +3 more
core +2 more sources
Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1
The FEBS Journal, Volume 293, Issue 12, Page 3502-3527, June 2026.PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio +12 more
wiley +1 more source
Management of Severe Attacks of Ulcerative Colitis with New Technologies
Canadian Journal of Gastroenterology, 1990 Barium enema and colonoscopy are contraindicated in severe attacks of ulcerative colitis because of the possibility of toxic megacolon and perforation.
M Campieri +9 more
doaj +1 more source
Toxic Megacolon: Background, Pathophysiology, Management Challenges and Solutions [Corrigendum]
Clinical and Experimental Gastroenterology, 2021 Desai J, Elnaggar M, Hanfy AA, Doshi R. Clin Exp Gastroenterol. 2020;13:203—210. The authors wish to add the following reference to the end of the reference section on page 210. 60. UpToDate Inc. Toxic megacolon. Alphen aan den Rijn: Wolters Kluwer;
Desai J, Elnaggar M, Hanfy AA, Doshi R
doaj
IJU Case Reports, Volume 9, Issue 3, May 2026.ABSTRACT Introduction Combination therapy with immune checkpoint inhibitors (ICIs) has become a standard treatment for metastatic renal cell carcinoma (mRCC). However, ICIs may also cause immune‐related adverse events. We report a case of mRCC that developed fulminant immune‐related enterocolitis.
Kasumi Kanai +9 more
wiley +1 more source
Clostridium Difficile Infection Complicated By Toxic Megacolon In Immunocompetent Patient
, 2017 Toxic megacolon can be a form of severe clinical course of the infection with Clostridium difficile (ICD), life-threatening, requiring a particular course of treatment.
Alina Iancu +5 more
core +1 more source
Present and past perspectives on Clostridium difficile infection
Revista de Gastroenterología de México (English Edition), 2018 Clostridium difficile is a Gram-positive bacillus that has become one of the main hospital-acquired human gastrointestinal infections in recent years.
D.A. Álvarez-Hernández +5 more
doaj +1 more source