Results 61 to 70 of about 5,495 (201)

Exploratory Clinical Study to Evaluate the Efficacy and Safety of Sulfasalazine for Immune Checkpoint Inhibitor (ICI)‐Induced Colitis

JGH Open, Volume 10, Issue 2, February 2026.
ABSTRACT Background The first‐choice treatment for immune checkpoint inhibitor (ICI)‐induced colitis is steroids; however, side effects may occur and survival may be reduced. Sulfasalazine (SSZ) is primarily used for inflammatory bowel disease but studies on ICI‐induced colitis are scarce.
Mariko Kobayashi, Takeshi Yamada, Shunsuke Ueyama, Yoshiyuki Yamamoto, Akinori Sugaya, Yoshinori Hiroshima, Takashi Mamiya, Junji Hattori, Shintaro Akiyama, Bryan J. Mathis, Kiichiro Tsuchiya   +10 more
wiley   +1 more source

Pseudomembranous colitis and toxic megacolon due to C. difficile in an inpatient hospitalized for home accident

Clinical Management Issues, 2015
Clostridium difficile infection (CDI) is the main cause of hospital-acquired diarrhea. It can result in symptoms ranging from moderate diarrhea to pseudomembranous colitis.
Piergiorgio Chiriacò
doaj   +1 more source

Preliminary non‐comparative evaluation of an adapted colonoscopy preparation protocol for dogs using sodium picosulphate and magnesium citrate

Veterinary Record, Volume 198, Issue 3, Page e101-e107, 31 January/7 February 2026.
Abstract Background Challenges associated with bowel cleansing protocols for canine colonoscopy include practical applicability and inadequate preparations. This study aimed to describe and evaluate an adapted protocol to simplify colonoscopy preparation in dogs.
Julia Elia da Silva Paranhos, Melissa Guillen Gonçalves de Souza, Daniela Araujo de Sousa, Debora Costabile Soibelman, Sabrina Martins da Costa Ferreira, Juliana da Silva Leite, Bruno Penna, Ana Maria Reis Ferreira   +7 more
wiley   +1 more source

Surgical Management for Patients with Toxic Megacolon due to Ulcerative Colitis

Journal of the Anus, Rectum and Colon
Objectives: The present study reviewed cases of Toxic megacolon (TM) treated in our department, summarized the timing and technique of surgery, and considered key points for surgical management.
Toshifumi Watanabe, Daijiro Higashi, Hiroki Kaida, Hisatoshi Irie, Katsuzo Hanaoka, Jin Yamakado, Toshimitsu Maki, Yosuke Hirano, Hideki Nagano, Masato Watanabe   +9 more
doaj   +1 more source

Two Cases of Severe Ulcerative Colitis with Colonic Dilatation Resolved with Tacrolimus Therapy

Case Reports in Gastroenterology, 2015
We report 2 cases of ulcerative colitis (UC) with intestinal tract dilatation treated with tacrolimus. They were 53- and 64-year-old males, who had been admitted to local hospitals for increasing severity of their UC symptoms. Treatment for severe UC was
Ryohei Hayashi, Yoshitaka Ueno, Shinji Tanaka, Shintaro Sagami, Kenta Nagai, Norifumi Shigemoto, Shinnosuke Uegami, Wataru Shimizu, Yusuke Watadani, Hiroki Ohge, Kazuaki Chayama   +10 more
doaj   +1 more source

Inflammatory bowel disease and metabolic reprogramming: From pathological mechanisms to targeted interventions

Interdisciplinary Medicine, Volume 4, Issue 1, January 2026.
This review explores the role of metabolic reprogramming in inflammatory bowel disease (IBD) by focusing on immune and epithelial cell metabolism, microbial metabolites, and their impact on inflammation. It discusses emerging metabolic therapies and emphasizes the importance of personalized microbiota‐targeted approaches to improve clinical outcomes in
Zemin Tian, Yinde Huang, Ying Wang, Chenyu Zhao, Zhaokai Zhou, Hua Yang, Yuan Qiu   +6 more
wiley   +1 more source

Gaps Between European Crohn's Colitis Organisation Quality Standards of Care and the Real World in Special Situations in Inflammatory Bowel Disease Across Europe: Results From E‐QUALITY Survey

JCC Plus, Volume 1, Issue 1, January 2026.
ABSTRACT Background Managing special situations in Inflammatory Bowel Disease (IBD)—such as surgery, nutrition, acute severe ulcerative colitis (ASUC) and paediatric‐to‐adult transition—is critical for patient outcomes. The European Crohn's and Colitis Organisation's (ECCO) E‐QUALITY initiative aimed to identify gaps between its evidence‐based care ...
Gionata Fiorino, Catarina Fidalgo, Michel Adamina, Manuel Barreiro‐de Acosta, Mariam P. Ali, Martin Bortlik, Johan Burisch, Axel Dignass, David Drobne, Omar Faiz, Marc Ferrante, Liselotte Fierens, Lihi Godny, Anna Gojdicova, Marietta Iacucci, Susanna Jӓghult, Konstantinos Karmiris, Julien Kirchgesner, Sophie Restellini, Francesca Rosini, Dror Shouval, Henit Yanai, Edyta Zagórowicz, Alissa Walsh, on behalf of European Crohn's Colitis Organisation   +24 more
wiley   +1 more source

Toxic megacolon during pregnancy in ulcerative colitis: A case report

, 2015
IntroductionUlcerative colitis is an idiopathic inflammatory bowel condition whose peak incidence coincides with fertility in female patients. In pregnancy, acute fulminant colitis is rare, and, when it becomes refractory to maximum medical therapy ...
Martin-Perez, Beatriz, Quddus, Ayyaz, Atallah, Sam, Schoonyoung, Henry, Albert, Matthew   +4 more
core   +1 more source

060. Chronic Megacolon with Recto Vaginal Fistulo Associated with Atresia Ani: A 26-Year History and Case Report

JBN (Jurnal Bedah Nasional)
Background: Large bowel obstruction and megacolon formation with rectovaginal fistule ascociated with atresia ani is rare. abnormal colon dilatation that falls into one of three categories: toxic, chronic, or acute.
I Gede Ryan Arditayasa, Gede Eka Rusdi Antara   +1 more
doaj   +1 more source

Radiology of acute toxic megacolon

, 2018
A case is described in which the transition from acute idiopathic ulcerative colitis to acute toxic megacolon was followed radioJogically, and the features which indicate the development of this dangerous complication are identified.S. Afr. Med.
Werbeloff, L, Marks, IN, Bank, S, Werbeloff, L., Marks, I.N., Novis, B, Bank, S., Novis, B.   +7 more
core