Results 51 to 60 of about 569,223 (149)

Tumor Infiltrating Lymphocyte Therapy Combined With PD‐1/LAG‐3 Inhibition in Patients With Recurrent Platinum‐Resistant Ovarian Cancer

International Journal of Cancer, Volume 159, Issue 7, Page 1735-1749, 1 October 2026.
The detection of tumor‐infiltrating lymphocytes (TILs) is a positive prognostic factor in ovarian cancer. Moreover, TILs are significantly boosted by immunotherapy, though ovarian cancer patients have seen limited benefit from immune therapies. This study investigated the safety and feasibility of TIL therapy combined with PD‐1 and LAG‐3 inhibitors in ...
Tine J. Monberg, Cathrine L. Lorentzen, Marie C. W. Westergaard, Trine Z. Iversen, Troels H. Borch, Marco Donia, Sigrid M. Mannering, Stine E. W. Banke, Özcan Met, Inge Marie Svane   +9 more
wiley   +1 more source

Toxic Megacolon: Background, Pathophysiology, Management Challenges and Solutions [Corrigendum]

Clinical and Experimental Gastroenterology, 2021
Desai J, Elnaggar M, Hanfy AA, Doshi R. Clin Exp Gastroenterol. 2020;13:203—210. The authors wish to add the following reference to the end of the reference section on page 210. 60. UpToDate Inc. Toxic megacolon. Alphen aan den Rijn: Wolters Kluwer;
Desai J, Elnaggar M, Hanfy AA, Doshi R
doaj  

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Present and past perspectives on Clostridium difficile infection

Revista de Gastroenterología de México (English Edition), 2018
Clostridium difficile is a Gram-positive bacillus that has become one of the main hospital-acquired human gastrointestinal infections in recent years.
D.A. Álvarez-Hernández, A.M. González-Chávez, D. González-Hermosillo-Cornejo, G.A. Franyuti-Kelly, A. Díaz-Girón-Gidi, R. Vázquez-López   +5 more
doaj   +1 more source

Lowering the C‐Reactive Protein (CRP) Threshold Improves Risk Stratification in Acute Ulcerative Colitis: A Propensity‐Matched Analysis

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 7, Page 985-1000, October 2026.
In 503 acute UC admissions, colectomy risk was equivalent between TWC‐positive ASUC and NASUC inpatients after propensity score matching for objective disease severity and treatment exposure; lowering the CRP threshold to ≥ 12 mg/L reclassified 26% of NASUC cases as ASUC and captured 43% of those requiring colectomy within one year, improving ...
Amirah Etchegaray, Naeman Goetz, Katherine Hanigan, Jennifer Phillips, Rina Kumar, George Tambakis, Graham Radford‐Smith, Gareth Walker, Anthony Croft   +8 more
wiley   +1 more source

Review Article: Immune Effector Cell‐Mediated Enterocolitis Following CAR‐T Cell Therapy—Clinical Features, Pathophysiology and Management

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 8, Page 1046-1057, October 2026.
Immune effector cell‐mediated enterocolitis is an emerging complication of CAR‐T therapy. This review summarizes its epidemiology, pathophysiology, diagnosis, endoscopic and histopathologic features, and evidence‐based management, emphasizing early recognition, multidisciplinary intervention, and step‐up therapy.
John A. Damianos, Yi Lin, Zongming Eric Chen, Kenneth J. C. Lim, Navreet M. Chowla   +4 more
wiley   +1 more source

Lymphocyte‐C‐Reactive Protein Ratio as Promising New Marker for Predicting Surgical Site Infection in Children With Ulcerative Colitis

Annals of Gastroenterological Surgery, Volume 10, Issue 5, Page 1586-1593, September 2026.
This study identifies the preoperative lymphocyte‐to–C‐reactive protein ratio (LCR) as a potent and independent biomarker for predicting surgical site infection (SSI) in pediatric patients undergoing major surgery for ulcerative colitis. ROC analysis established an optimal cutoff of 5000 (AUC: 0.80), which demonstrated robust predictive performance ...
Yuhki Koike, Koki Higashi, Yuki Sato, Yuka Nagano, Tadanobu Shimura, Takahito Kitajima, Kohei Matsushita, Yoshiki Okita, Yoshinaga Okugawa, Yuji Toiyama   +9 more
wiley   +1 more source

Multiomics analyses revealed the roles of the epithelial–mesenchymal transition and novel early candidate diagnostic biomarkers in neonatal necrotising enterocolitis

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
In infants with necrotising enterocolitis (NEC), excessive inflammation and epithelial cell death promote the epithelial–mesenchymal transition (EMT), leading to damage to intestinal barriers and the translocation of bacteria and toxins. In addition, inflamed epithelia release cytokines to strengthen the inflammatory response.
Xiao‐Chen Liu, Guo‐Bin Liu, Chen Cheng, Jin Zhu, Fei‐Fan Chen, Ying Ji, Yu‐Ni Zhang, Xiao‐Lin Yan, Qing Wang, Xin‐Yu Li, Qing Ai, Yuan Shi, Yu He   +12 more
wiley   +1 more source

Toxic Megacolon: A rare complication of chronic constipation. Three Pediatric Cases

, 2022
Introducción: La constipación crónica es una patología frecuente en la edad pediátrica, que afecta la calidad de vida de los pacientes y su familia. Su manejo suele ser complejo y prolongado.
Muñoz P., Macarena, Santos M., Marcela, Andueza A., Fernanda   +2 more
core   +1 more source

A rare and severe case of toxic megacolon: Radiological emergency

Radiology Case Reports
Toxic megacolon is a rare and life-threatening complication of ulcerative colitis, representing a medical and surgical emergency with a poor prognosis.We report the case of a 31-year-old man with no significant past medical history, admitted for a 15-day
Salma Abddaimi, MD, Hicham Benramdane, MD, Adnane Boubacar, MD, Hamid Ziani, MD, Siham Nasri, MD, Imane Kamaoui, MD, Imane Skiker, MD   +6 more
doaj   +1 more source