Results 41 to 50 of about 22,318 (247)

Chagas disease reactivation in a heart transplant patient infected by domestic Trypanosoma cruzi discrete typing unit I (TcIDOM) [PDF]

, 2015
Background Trypanosoma cruzi, causative agent of Chagas disease, displays high intraspecific genetic diversity: six genetic lineages or discrete typing units (DTUs) are currently recognized, termed TcI through TcVI.
Bhattacharyya, T., Burleigh, B.A., Costales, J.A., Garcia-Perez, J., Kotton, C.N., Llewellyn, M.S., Messenger, L.A., Zurita-Leal, A.C.   +7 more
core   +2 more sources

Enteric Neuronal Damage, Intramuscular Denervation and Smooth Muscle Phenotype Changes as Mechanisms of Chagasic Megacolon: Evidence from a Long-Term Murine Model of Tripanosoma cruzi Infection

PLoS ONE, 2016
We developed a novel murine model of long-term infection with Trypanosoma cruzi with the aim to elucidate the pathogenesis of megacolon and the associated adaptive and neuromuscular intestinal disorders.
C. F. Campos, S. D. Cangussú, A. L. C. Duz, C. T. Cartelle, M. L. M. Noviello, V. M. Veloso, M. T. Bahia, C. Almeida-Leite, R. Arantes   +8 more
semanticscholar   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Atresia anal tipo III com presença de fístula vaginal e megacólon: Relato de caso

Pubvet, 2018
O presente relato de caso tem como objetivo apresentar um caso de atresia anal tipo III, com megacólon e fistula vaginal em cão sem raça definida. A técnica cirúrgica utilizada e a conduta pós cirúrgica com a realização de enemas diários e hidratação foi
Tairine Melo Costa, Samuel Otemi de Sousa Silva, Thamara Barrozo Sampaio, Daniele Benigno Mota, Vanessa Brígida Pinheiro Rodrigues, Jéssica Maria da Silva Sousa, Aline Silva Santos, Ana Gabriela Pereira Moura Leite   +7 more
doaj   +1 more source

Massive Megacolon Due to Giant Faecaloma of the Sigmoid Colon in an Elderly Patient

Turkish Journal of Colorectal Disease, 2020
Faecaloma is a mass of inspissated faeces, typically found in the rectosigmoid colon. Furthermore, faecalomas may cause intestinal obstruction, stercoral ulcer development and colon perforation, which may be due to the pressure effect of large faecal ...
Zafer Teke, Orçun Yalav, Osman Erdoğan, İshak Aydın   +3 more
doaj   +1 more source

Constipation Is Related to Small Bowel Disturbance Rather Than Colonic Enlargement in Acquired Chagasic Megacolon

Gastroenterology Research, 2017
Background Constipation is the main symptom of acquired chagasic megacolon. However, a number of patients with Chagas disease without colon involvement also have the same complain. This study evaluated the role of small bowel in constipated patients with
M. Bafutto, A. Luquetti, Salustiano Gabriel Neto, F. A. S. Penhavel, E. Oliveira   +4 more
semanticscholar   +1 more source

Electro‐clinical features of Mowat–Wilson syndrome: A retrospective study of 31 children in mainland China

Epileptic Disorders, EarlyView.
Abstract Objective To summarize the electro‐clinical and genetic characteristics of children with Mowat–Wilson syndrome (MWS). Methods This study is a hospital‐based case series analyzing clinical data from 31 pediatric patients with MWS and epilepsy treated at Peking University First Hospital between June 2020 and December 2024.
Yi Ju, Tao‐yun Ji
wiley   +1 more source

Successfully Treated Pediatric Patient With Megarectum by Vertical Reduction Rectoplasty [PDF]

Iranian Journal of Colorectal Research, 2014
This report represents successful treatment of a seven-year-old boy with megarectum, who complained of intractable constipation and encopresis, by vertical reduction rectoplasty.
Ibrahim Akkoyun
doaj   +1 more source

A tetraspecific VHH-based neutralizing antibody modifies disease outcome in three animal models of Clostridium difficile infection [PDF]

, 2016
Clostridium difficile infection (CDI), a leading cause of nosocomial infection, is a serious disease in North America, Europe, and Asia. CDI varies greatly from asymptomatic carriage to life-threatening diarrhea, toxic megacolon, and toxemia.
Beamer, Gillian, Curiel, David T, Debatis, Michele, Dmitriev, Igor P, Kashentseva, Elena A, Kim, Hyeun Bum, Schmidt, Diane J, Shoemaker, Charles B, Steele, Jennifer A, Sun, Xingmin, Tremblay, Jacqueline M, Tzipori, Saul, Wang, Yaunkai   +12 more
core   +2 more sources

Long‐term outcomes of children with ulcerative colitis after acute severe colitis: A GETAID pédiatrique multicenter study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Acute severe colitis (ASC) is a frequent and severe complication of ulcerative colitis (UC) with a high risk of colectomy. Effects of immunosuppressants and anti–tumor necrosis factor (anti‐TNF) agents on the risk of colectomy remain debated. We wished to study the evolution of French pediatric‐onset UC patients after ASC.
Manon Cochet, Agathe Beauvais, Frank Ruemmele, Raphael Enaud, Thierry Lamireau, Rémi Duclaux‐Loras, Claire Dupont, Stéphanie Willot, Laure Bridoux‐Henno, Georges Dimitrov, Julie Lemale, Vincent Guinard‐Samuel, Valérie Bertrand, Anne Breton, Christine Martinez Vinson, Stéphanie Coopman, Delphine Ley, Bénédicte Pigneur, and the Groupe d'Etudes Thérapeutiques des Affections Inflammatoires du tube Digestif (GETAID) pédiatrique   +18 more
wiley   +1 more source