Results 231 to 240 of about 24,025 (269)
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DISTRIBUTION OF INTRAPULMONARY MEGAKARYOCYTES
Acta Pathologica Microbiologica Scandinavica Section A Pathology, 1981The distribution of intrapulmonary megakaryocytes is equal in healthy persons, but altered in diseased persons, the highest counts being found in superior lobes (p = 0.0027). This may be explained by the altered blood supply to the lungs of diseased persons lying in bed. We recommend that lung sections should be taken from central areas of the superior
K, Bendix-Hansen, K, Aabo
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Megakaryocyte endomitosis: A review
The International Journal of Cell Cloning, 1990During the early stages of their differentiation, megakaryocytes become polyploid through repeated DNA replication and endomitotic cycles without cytokinesis. The molecular basis for the process of polyploidization remains unknown. This review summarizes available information on the cell biology of the process of endomitosis.
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Systems Biology of Megakaryocytes
2014The molecular pathways that regulate megakaryocyte production have historically been identified through multiple candidate gene approaches. Several transcription factors critical for generating megakaryocytes were identified by promoter analysis of megakaryocyte-specific genes, and their biological roles then verified by gene knockout studies; for ...
Alexis, Kaushansky, Kenneth, Kaushansky
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[Megakaryocytic leukemia cell lines and megakaryocytic leukemia].
Rinsho byori. The Japanese journal of clinical pathology, 1990Using the megakaryocytic leukemia cell lines, K-562 and CMK established from a Down's patient with acute megakaryoblastic leukemia, we studied the changes of antigen expression, cytosolic Ca2+ mobilization, thromboxane (TX) A2 formation and gene expression during megakaryocyte differentiation. We found that thrombospondin synthesis and platelet factor (
R, Ryo, A, Yoshida, N, Yamaguchi
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Enzymatic Abnormalities in Megakaryocytes
Acta Haematologica, 2009Cytochemical studies of various enzymes were carried out on megakaryocytes obtained from patients with disorders of megakaryocytes. In patients with idiopathic thrombocytopenic purpura megakaryocytes have uniformly low levels of the enzymes studied, as estimated by formazan deposition.
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Megakaryocytes and atherosclerosis
Clinical Science, 1992S D, Kristensen, J F, Martin
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MicroRNA Profiling of Megakaryocytes
2009MiRNAs are non-coding RNAs of 19-25 nucleotides in length that regulate gene expression. Recent work suggests a role for miRNAs during hematopoiesis. Here, we described in detail how to successfully obtain highly pure megakaryocytes precursors from human CD34+ stem cells in culture to perform high-throughput miRNA profiling using a custom microarray ...
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