The cohesin complex in mammalian meiosis
Genes to Cells, 2018 Cohesin is an evolutionary conserved multi‐protein complex that plays a pivotal role in chromosome dynamics. It plays a role both in sister chromatid cohesion and in establishing higher order chromosome architecture, in somatic and germ cells.
K. Ishiguro
semanticscholar +1 more source
CENH3-GFP: a visual marker for gametophytic and somatic ploidy determination in Arabidopsis thaliana [PDF]
, 2016 Background: The in vivo determination of the cell-specific chromosome number provides a valuable tool in several aspects of plant research. However, current techniques to determine the endosystemic ploidy level do not allow non-destructive, cell-specific
Angenon, Geert +4 more
core +5 more sources
Positive regulation of meiotic DNA double-strand break formation by activation of the DNA damage checkpoint kinase Mec1(ATR) [PDF]
, 2013 During meiosis, formation and repair of programmed DNA double-strand breaks (DSBs) create genetic exchange between homologous chromosomes-a process that is critical for reductional meiotic chromosome segregation and the production of genetically diverse ...
Allison, Rachal M +4 more
core +1 more source
Wellcome Open Research, 2017 Background Gametes are generated through a specialized cell division called meiosis, in which ploidy is reduced by half because two consecutive rounds of chromosome segregation, meiosis I and meiosis II, occur without intervening DNA replication.
Colette Fox +3 more
doaj +1 more source
Meiosis-specific cohesin component, Stag3 is essential for maintaining centromere chromatid cohesion, and required for DNA repair and synapsis between homologous chromosomes. [PDF]
PLoS Genetics, 2014 Cohesins are important for chromosome structure and chromosome segregation during mitosis and meiosis. Cohesins are composed of two structural maintenance of chromosomes (SMC1-SMC3) proteins that form a V-shaped heterodimer structure, which is bridged by
Jessica Hopkins +8 more
doaj +1 more source
The Consequences of Chromosome Segregation Errors in Mitosis and Meiosis
Biology, 2017 Mistakes during cell division frequently generate changes in chromosome content, producing aneuploid or polyploid progeny cells. Polyploid cells may then undergo abnormal division to generate aneuploid cells.
T. Potapova, G. Gorbsky
semanticscholar +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Nature CommunicationsAneuploidy in eggs is a leading cause of miscarriages or viable developmental syndromes. Aneuploidy rates differ between individual chromosomes. For instance, chromosome 21 frequently missegregates, resulting in Down Syndrome.
Eirini Bellou +8 more
doaj +1 more source
Positive feedback of NDT80 expression ensures irreversible meiotic commitment in budding yeast. [PDF]
PLoS Genetics, 2014 In budding yeast, meiotic commitment is the irreversible continuation of the developmental path of meiosis. After reaching meiotic commitment, cells finish meiosis and gametogenesis, even in the absence of the meiosis-inducing signal. In contrast, if the
Dai Tsuchiya, Yang Yang, Soni Lacefield
doaj +1 more source
Mechanisms of Oocyte Maturation and Related Epigenetic Regulation
Frontiers in Cell and Developmental Biology, 2021 Meiosis is the basis of sexual reproduction. In female mammals, meiosis of oocytes starts before birth and sustains at the dictyate stage of meiotic prophase I before gonadotropins-induced ovulation happens. Once meiosis gets started, the oocytes undergo
Meina He +8 more
doaj +1 more source