Results 111 to 120 of about 30,580 (249)

Meiotic recombination and male infertility: from basic science to clinical reality? [PDF]

, 2011
Infertility is a common problem that affects approximately 15% of the population. Although many advances have been made in the treatment of infertility, the molecular and genetic causes of male infertility remain largely elusive. This review will present
Hann, Michael C., Lau, Patricio E., Tempest, Helen G.   +2 more
core   +1 more source

Mesenchymal Stem Cells From a Klinefelter Syndrome Patient: Functional Characterization and Therapeutic Implications

Andrology, EarlyView.
ABSTRACT Background Cell therapy, particularly those utilizing mesenchymal stem/stromal cells (MSCs), is gaining traction as a therapeutic option for regenerative treatment in patients with limited therapeutic options. Although the safety of MSC‐based interventions is well established, uncertainties remain regarding how genetic abnormalities and ...
Marzena Zychowicz, Wioletta Lech, Anna Figiel‐Dabrowska, Marta Kot, Magdalena Murzyn, Natalia Malawska, Barbara Pienkowska‐Grela, Zuzanna Sandowska‐Markiewicz, Iwona Ziolkowska‐Suchanek, Agnieszka Zimna, Tomasz Oldak, Natalia Rozwadowska, Anna Sarnowska   +12 more
wiley   +1 more source

Altered cohesin gene dosage affects Mammalian meiotic chromosome structure and behavior.

PLoS Genetics, 2013
Based on studies in mice and humans, cohesin loss from chromosomes during the period of protracted meiotic arrest appears to play a major role in chromosome segregation errors during female meiosis.
Brenda Murdoch, Nichole Owen, Michelle Stevense, Helen Smith, So Nagaoka, Terry Hassold, Michael McKay, Huiling Xu, Jun Fu, Ekaterina Revenkova, Rolf Jessberger, Patricia Hunt   +11 more
doaj   +1 more source

Analysis of small RNAs revealed differential expressions during pollen and embryo sac development in autotetraploid rice [PDF]

, 2017
Protein-protein interaction of meiosis-related genes with the targets predicted by the DEM associated with meiosis. Table S18. 21 nt-phasiRNAs triggered by the miR2118. Table S19. 24 nt-phasiRNAs triggered by the miR2275. Table S20. Overview of 24 nt TEs-
Jinwen Wu, Juan Xia, Lan Wang, Muhammad Qasim Shahid, Na Fang, Xiang Li, Xiangdong Liu, Zhixiong Chen, Zijun Lu   +8 more
core   +5 more sources

Assessing a Model for a Complex Systemic Disorder—The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research

Andrology, EarlyView.
ABSTRACT Introduction Direct experimental investigation of Klinefelter syndrome (KS) in patients is limited because the syndrome manifests heterogeneously and affects multiple organ systems. Studying KS therefore requires a model that captures this complexity as accurately as possible while still permitting controlled experimental manipulation ...
Fariba Saadati, Joachim Wistuba
wiley   +1 more source

Anàlisi citogenètica d'espermatozoides humans [PDF]

, 2009
Les anomalies cromosòmiques són una de les principals causes d'esterilitat en l'espècie humana. A les anomalies del cariotip, molt més freqüents en individus que consulten per problemes reproductius que en la població general, s'afegeixen les anomalies ...
Anton, Ester, Blanco, Joan, Sarrate, Zaida, Vidal, Francesca   +3 more
core  

From a novel pathogenic SAMD9L variant to cohort‐wide insights: Whole‐genome sequencing highlights somatic genetic rescue and phenotypic heterogeneity

British Journal of Haematology, EarlyView.
Summary Germline gain‐of‐function variants in sterile alpha motif domain–containing 9‐like (SAMD9L), located on chromosome 7q, cause a multisystem disorder characterized by bone marrow failure, immunodeficiency and variable neurological involvement. Disease evolution is frequently shaped by somatic genetic rescue (SGR), most commonly through monosomy 7,
Hadjer Dellal, Roman Klifa, Lise Larcher, Marie Passet, Tristan Celse, Laetitia Gouas, Maud Tusseau, AURAGEN Consortium, Alexis Praga, Virginie Bernard, Mathieu Fusaro   +10 more
wiley   +1 more source

Exposure of Tradescantia Microspores to Periodic Vibrations of 40-100 Hertz [PDF]

Spherical chromosomal fragments determined in exposure of Tradescantia microspores to periodic ...
Bales, L. J., Knepton, J. C., Jr.
core   +1 more source

Analysis of Human Uniparental Embryonic Stem Cells Reveals New Putative Imprinted Loci

Cell Proliferation, EarlyView.
To identify novel imprinted genes, parthenogenetic, androgenetic and biparental human embryonic stem cells and their differentiated neural progenitors were analysed by methylome and transcriptome profiling. This approach uncovered 12 putative novel imprinted genes, including a clustered region on chromosome 19, expanding the current catalogue of ...
Shay Kinreich, Nissim Benvenisty
wiley   +1 more source

Anthropogenic Impacts on Meiosis in Plants

Frontiers in Plant Science, 2018
As the human population grows and continues to encroach on the natural environment, organisms that form part of such ecosystems are becoming increasingly exposed to exogenous anthropogenic factors capable of changing their meiotic landscape.
Lorenz K. Fuchs, Glyn Jenkins, Dylan W. Phillips   +2 more
doaj   +1 more source