Results 91 to 100 of about 61,553 (233)

Spatiotemporal regulation of meiotic recombination by Liaisonin [PDF]

BioArchitecture, 2013
Sexual reproduction involves diversification of genetic information in successive generations. Meiotic recombination, which substantially contributes to the increase in genetic diversity, is initiated by programmed DNA double-strand breaks (DSBs) catalyzed by the evolutionarily conserved Spo11 protein. Spo11 requires additional partner proteins for its
Miyoshi, Tomoichiro, Ito, Masaru, Ohta, Kunihiro   +2 more
openaire   +2 more sources

Chromodomain Helicase DNA–Binding Proteins and Spermatogenesis: Current Advances

Andrology, EarlyView.
ABSTRACT Background Male infertility is a prevalent clinical condition, with approximately one‐third of cases classified as idiopathic, frequently stemming from impaired spermatogenesis because of dysregulated gene expression. Chromodomain helicase DNA‐binding (CHD) proteins are central chromatin remodelers that orchestrate this epigenetic regulation ...
Mingrui Zhang, Di Liu, Guoqiang Liu, Minggang Zhu, Feng Pan   +4 more
wiley   +1 more source

FISH landmarks reflecting meiotic recombination and structural alterations of chromosomes in wheat (Triticum aestivum L.)

BMC Plant Biology, 2021
Background DNA sequence composition affects meiotic recombination. However, the correlation between tandem repeat composition and meiotic recombination in common wheat (Triticum aestivum L.) is unclear.
Yang Zou, Linrong Wan, Jie Luo, Zongxiang Tang, Shulan Fu   +4 more
doaj   +1 more source

Distinct requirements for the Rad32(Mre¹¹) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA [PDF]

, 2009
For a cancer cell to resist treatment with drugs that trap topoisomerases covalently on the DNA, the topoisomerase must be removed. In this study, we provide evidence that the Schizosaccharomyces pombe Rad32Mre11 nuclease activity is involved in the ...
Akamatsu, Antony M. Carr, Baldwin, Champoux, Connelly, Connelly, Edgar Hartsuiker, El-Khamisy, Farah, Gutz, Hartsuiker, Hopfner, Hopfner, Keeney, Keeney, Krogh, Krogh, Lengsfeld, Limbo, Liu, Malik, Matthew J. Neale, McKee, Miyoshi, Moreau, Neale, Nitiss, Osheroff, Porter, Pouliot, Prinz, Sartori, Shaw, Stracker, Subramanian, Takashima, Tomita, Utsugi, Young   +38 more
core   +2 more sources

SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis

Cell Proliferation, EarlyView.
The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu, Wenfeng Zhang, Xiao Jiang, Jianping Chen, Lei Zhu, Zhonghao Zhang, Jing Gu, Lulu Guo, Lin Ao, Qing Chen, Lei Sun, Yuhan Hu, Xin Wang, Yaxin Liu, Jia Cao, Fei Han, Jinyi Liu   +16 more
wiley   +1 more source

Identification of Putative Mek1 Substrates during Meiosis in Saccharomyces cerevisiae Using Quantitative Phosphoproteomics.

PLoS ONE, 2016
Meiotic recombination plays a key role in sexual reproduction as it generates crossovers that, in combination with sister chromatid cohesion, physically connect homologous chromosomes, thereby promoting their proper segregation at the first meiotic ...
Raymond T Suhandynata, Lihong Wan, Huilin Zhou, Nancy M Hollingsworth   +3 more
doaj   +1 more source

Homologous recombination mutants cause differing lethality between h− and h+ Schizosaccharomyces pombe strains due to mat1 heterochromatin

The FEBS Journal, EarlyView.
Homologous recombination (HR) in Schizosaccharomyces pombe is essential when mating‐type switching–induced double‐strand breaks (DSBs) form at the mat1 locus. In h90 and h− strains, efficient mat1 DSB formation renders HR indispensable unless suppressors block these breaks.
Peter Kolesar, Siarhei Paliavoi, Barbora Stefanovie, Jan Josef Palecek   +3 more
wiley   +1 more source

Gene conversion occurs within the mating-type locus of Cryptococcus neoformans during sexual reproduction. [PDF]

PLoS Genetics, 2012
Meiotic recombination of sex chromosomes is thought to be repressed in organisms with heterogametic sex determination (e.g. mammalian X/Y chromosomes), due to extensive divergence and chromosomal rearrangements between the two chromosomes.
Sheng Sun, Yen-Ping Hsueh, Joseph Heitman   +2 more
doaj   +1 more source

DNA resection in eukaryotes: deciding how to fix the break [PDF]

, 2010
DNA double-strand breaks are repaired by different mechanisms, including homologous recombination and nonhomologous end-joining. DNA-end resection, the first step in recombination, is a key step that contributes to the choice of DSB repair.
A Aguilera, A Jazayeri, A Jazayeri, A Penkner, AA Sartori, AH McKee, AV Nimonkar, B Gu, BB Hopkins, BM Lengsfeld, BO Krogh, C Uanschou, C Zierhut, CF Cheok, CJ Lord, D Mantiero, D Nakada, DA Bressan, DO Warmerdam, E Baroni, EP Mimitou, F Lazzaro, G Chinnadurai, G Ira, G Wu, I Morin, J Buis, J Falck, JC Harrison, JH Barlow, JH Kim, JP Duxin, K Lee, K Shimada, KM Trujillo, L Chen, L Chen, L Maringele, L Zheng, M Clerici, M Clerici, M Grenon, M Lisby, M McVey, MF Lavin, MH Yun, MJ Neale, MR Lieber, O Limbo, P Huertas, P Huertas, Pablo Huertas, PL Chen, PT Tran, R Linding, R Waltes, RR Khakhar, RS Williams, S Gravel, S Liao, S Moreau, S Prinz, SH Bae, SK Amundsen, T Usui, TH Stracker, TT Paull, WS Dynan, X Yu, X Yu, Y Akamatsu, Y Aylon, Y Zhang, Z Horejsí, Z Zhu   +74 more
core   +1 more source

Hybrid sorghum breeding in China: A historical review and perspectives

Journal of Integrative Plant Biology, EarlyView.
To commemorate the 60th anniversary of the promotion and application of three‐line hybrid sorghum in China, this review highlights pivotal scientific breakthroughs, systematically summarizes the progress in hybrid sorghum breeding and dwarf sorghum breeding in the country, and presents an outlook on the future of sorghum breeding.
Xiangxiang Meng, Lu Li, Qian Qian, Liang Jiang, Zhaosheng Kong   +4 more
wiley   +1 more source