Results 111 to 120 of about 33,318 (207)

PKMYT1 in Cancer: Beyond Cell Cycle Checkpoints to Context‐Dependent Therapeutic Vulnerability

Genes, Chromosomes and Cancer, Volume 65, Issue 7, July 2026.
ABSTRACT PKMYT1 has emerged as a promising therapeutic target distinguished by its tumor‐selective expression and essential role in replication stress management. Unlike WEE1, PKMYT1 is dispensable in normal cell cycles but critical for cancer cells coping with DNA damage, establishing a broad therapeutic window.
Lingxi Li, Binfan He, Mengmeng Hao, Ye Liu, Shunxin Song, Rongzhang He   +5 more
wiley   +1 more source

Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers

MedComm, Volume 7, Issue 7, July 2026.
This schematic illustrates the hierarchical and interconnected nature of the primary molecular hallmarks of aging. The progression of aging is driven by a convergence of intrinsic molecular insults. Within the nucleus, genomic instability and telomere attrition trigger persistent DDR, accompanied by extensive epigenetic alterations.
Guowei Cai, Jia Ren, Li Wang, Yingying Wu, Huirui Wang, Xiaomeng Cao, Hao Shang, Xuben Hou, Yujiu Wang, Haibo Xue, Ting Dong   +10 more
wiley   +1 more source

Evidence That Sri Lanka Is the Origin of a Rare Nematode Resistance Gene in Rice

Plant Direct, Volume 10, Issue 7, July 2026.
ABSTRACT Meloidogyne graminicola is a destructive and widespread pest in tropical rice‐growing systems, whereas resistance in Oryza sativa remains exceptionally rare. A major quantitative trait locus (QTL) associated with resistance has previously been identified at the distal end of chromosome 11 in the resistant varieties, LD 24 (Sri Lanka) and KPM ...
S. Yashodha S. D. De Silva, Ceilan Handy, Eduard Roumen, M. L. A. M. S. Munasinghe, Adam H. Price   +4 more
wiley   +1 more source

Interaction Between Rec8 and Mis4 Is Required for Axis‐Loop Chromatin Formation and Homologous Chromosome Recombination During Meiosis

Genes to Cells, Volume 31, Issue 4, July 2026.
We identified a Mis4 cohesin loader mutant that is specifically defective in chromatin axis formation and homologous recombination while retaining normal sister chromatid cohesion. The mis4‐LR mutant, carrying the L1150S and R1159G amino acid substitutions, exhibited reduced interaction between Mis4 and Rec8, suggesting a meiosis‐specific role for the ...
Takeshi Sakuno, Yasuto Murayama, Tokuko Haraguchi, Yasushi Hiraoka   +3 more
wiley   +1 more source

Reduced Mechanical Tactile Stimulation Under Space Microgravity Affects Synaptic Signaling and Contributes to Neuromuscular Aging in Caenorhabditis elegans

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Microgravity (μG) reduces mechanical tactile stimulation in Caenorhabditis elegans, causing neuromuscular decline, altered gene expression, synaptic defects, and accelerated aging phenotypes. The gentle‐touch mechanoreceptor MEC‐4 mediates μG‐induced body length reduction and extracellular matrix gene downregulation.
Atsushi Higashitani, Je‐Hyun Moon, Jong‐In Hwang, Nahoko Higashitani, Toko Hashizume, Ahmad Aisha Abu, Kazuki Ooizumi, Ibuki Sazuka, Yoshimitsu Hashizume, Masumi Umehara, Alfredo V. Alcantara Jr, Ban‐seok Kim, Timothy Etheridge, Nathaniel J. Szewczyk, Takaaki Abe, Jin I. Lee, Akira Higashibata   +16 more
wiley   +1 more source

Meiotic double-strand break repair DNA synthesis tracts in Arabidopsis thaliana.

PLoS Genetics
We report here the successful labelling of meiotic prophase I DNA synthesis in the flowering plant, Arabidopsis thaliana. Incorporation of the thymidine analogue, EdU, enables visualisation of the footprints of recombinational repair of programmed ...
Miguel Hernández Sánchez-Rebato, Veit Schubert, Charles I White   +2 more
doaj   +1 more source

Essential roles of the ANKRD31-REC114 interaction in meiotic recombination and mouse spermatogenesis. [PDF]

Proc Natl Acad Sci U S A, 2023
Xu J, Li T, Kim S, Boekhout M, Keeney S.
europepmc   +1 more source

Modifying meiotic recombination by targeting chromatin regulators to crossover hotspots in <i>Arabidopsis</i>. [PDF]

Sci Adv
Szymanska-Lejman M, Dziegielewski W, Wilhelm A, Hus K, Ziolkowski PA.   +4 more
europepmc   +1 more source

Population genomics reveals meiotic recombination in Fusarium oxysporum. [PDF]

Proc Natl Acad Sci U S A, 2023
Fokkens L, Rep M.
europepmc   +1 more source

The dynamic pool of Rec8-cohesin is crucial for meiotic recombination and transcription regulation in the yeast Saccharomyces cerevisiae. [PDF]

J Biol Chem
Paliwal S, Dey P, Kumari A, Sadasivam K, Joshi S, Raghuvanshi R, Goyal R, Sanyal K, Nishant KT, Shinohara A, Mehta G.   +10 more
europepmc   +1 more source