Results 101 to 110 of about 33,318 (207)

Biallelic Germline Inactivation of HROB Causes Primary Gonadal Insufficiency and is Potentially Associated with Colonic Polyposis Predisposition

open access: yesAmerican Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1773-1782, August 2026.
ABSTRACT The Homologous Recombination Factor With OB‐Fold (HROB) plays a role in homologous recombination and DNA replication, where it enhances the MCM8‐MCM9 helicase complex activity. Recent findings link biallelic germline HROB variants to primary gonadal insufficiency (hypergonadotropic hypogonadism), a phenotype also associated with MCM8/MCM9 ...
Noah C. Helderman   +15 more
wiley   +1 more source

The power of many: when genetics met yeasts and high‐throughput

open access: yesBiological Reviews, Volume 101, Issue 4, Page 1662-1682, August 2026.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

Long‐term surveillance reveals hybridization by nuclear reassortment and intercontinental spread as major evolutionary drivers in wheat yellow rust

open access: yesNew Phytologist, Volume 251, Issue 4, Page 2091-2106, August 2026.
Documented incursions of Puccinia striiformis 2009–2023 based on sequential resampling of MLGs/pathogen races on different continents. Summary Evolutionary forces affecting crop pathogens, including hybridization and long‐distance dispersal (LDD), may have strong implications for food security and sustainable plant disease control at global scales ...
Mogens Støvring Hovmøller   +14 more
wiley   +1 more source

Accessory regions and horizontal gene transfer shape the evolution of clonal Colletotrichum nymphaeae infecting strawberry

open access: yesNew Phytologist, Volume 251, Issue 4, Page 2186-2205, August 2026.
Genetic diversity of strawberry‐infecting Colletotrichum isolates. Summary Rapid adaptation in fungal plant pathogens is often attributed to sexual recombination, yet many important pathogens are largely clonal. We investigated how genetic and phenotypic diversity arises in the predominantly asexual fungus Colletotrichum nymphaeae, the main cause of ...
Joris A. Alkemade   +3 more
wiley   +1 more source

Kinetochore size correlates with chromosome size in Star of Bethlehem (Ornithogalum kochii Parl., Asparagaceae)

open access: yesPlant Biology, Volume 28, Issue 5, Page 1737-1742, August 2026.
Cytogenetic quantification of KNL1‐labelled kinetochores in Ornithogalum kochii reveals a significant positive scaling relationship between chromosome size and kinetochore size, demonstrating that chromosome–kinetochore scaling operates even across moderate intra‐karyotype size variation.
K. Panda, M. Hroneš, F. Zedek
wiley   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

open access: yesAdvanced Science, Volume 13, Issue 39, 13 July 2026.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal   +3 more
wiley   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

open access: yesAdvanced Science, Volume 13, Issue 39, 13 July 2026.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao   +7 more
wiley   +1 more source

The Landscape of BRCA1‐Associated Post‐Translational Modifications

open access: yesCell Biology International, Volume 50, Issue 7, July 2026.
ABSTRACT The BRCA1‐BARD1 complex is a vital protein that promotes homologous recombination, acting through its E3 ubiquitin ligase activity. Although ubiquitination remains its only confirmed enzymatic function, emerging evidence suggests that the complex influences a broad range of post‐translational modifications (PTMs), including methylation ...
Nethma Hewa Waduge   +2 more
wiley   +1 more source

Rust resistance in barley accessions County and BHS248

open access: yesCrop Science, Volume 66, Issue 4, July/August 2026.
Abstract Rusts can cause devastating losses of barley (Hordeum vulgare L.) in epidemic years. Several reactions to Puccinia hordei (Rph) genes/quantitative trait loci (QTLs) for resistance to barley leaf rust (BLR) have been documented. In contrast, there is a dearth of characterized resistance sources against stem rust (SR) caused by Puccinia graminis.
Kelly Jordaan   +7 more
wiley   +1 more source

Cytogenetic Analysis of Altitude‐Associated Chromosome Variations in Campeiostachys nutans From Western Sichuan Plateau Using Multicolor GISH and ND‐FISH Approaches

open access: yesEcology and Evolution, Volume 16, Issue 7, July 2026.
The genomic and chromosomal organization of C. nutans was investigated using GISH and ND‐FISH with four oligonucleotide probes. The results showed that repetitive sequence distribution exhibited genome‐specific patterns: the H genome demonstrated high structural stability with low polymorphism, while the St genome showed moderate variation, and the Y ...
Cairong Yang   +7 more
wiley   +1 more source

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