Results 141 to 150 of about 16,852 (174)
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Effects of cryopreservation on the meiotic spindle of human oocytes
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2004The microtubular meiotic spindle of most mammals, including humans, is very sensitive to cooling [Hum. Reprod. 16 (2001) 2374; Fertil. Steril. 54 (1990) 102; Fertil. Steril. 75 (2001) 769; Zygote 3 (1995) 357] and is rapidly depolymerised even after a slight reduction in temperature to 33 degrees C.
Mandelbaum, J. +5 more
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mInscuteable regulates meiotic spindle organization during mouse oocyte meiotic maturation
Zygote, 2019SummaryEstablishment of cellular polarity is one of the key events during oocyte maturation. Inscuteable (Insc) has been identified as a key regulator of cell polarity during asymmetric division in Drosophila. However, the function of its evolutionarily conserved mammalian homologue, mInscuteable (mInsc), in mouse meiotic maturation is not clear.
Zhuoni Xiao +4 more
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Role of chromosomes in assembly of meiotic and mitotic spindles
1997The assembly of a mitotic spindle requires the interaction of microtubules with chromosomes. As a cell enters mitosis, long microtubules are converted to short ones, as microtubules become unstable. Dynamic microtubules are then stabilised by chromosomes, forming a bipolar spindle.
R, Tournebize, R, Heald, A, Hyman
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The influence of cooling on the oranization of meiotic spindle of the mouse oocyte
Human Reproduction, 1987The effect of cooling on the organization of the microtubule system of the mouse oocyte has been investigated. Cooling to 25, 18 or 4 degrees C for varying periods of time resulted in a progressive disassembly of the spindle and the dispersal of the chromosomes.
S J, Pickering, M H, Johnson
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The distribution of intermicrotubular bridges in meiotic spindles of the crane fly
Chromosoma, 1986The distribution of intermicrotubular bridges in spindles of tipulid spermatocytes (Pales ferruginea, first meiotic division) was analyzed using serial sections of pre-selected cells. Bridges were found in all spindle regions, including kinetochore microtubules and free microtubules in the chromosome fiber.
M, Bastmeyer, H, Fuge
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Time course of meiotic spindle development in MII oocytes
Zygote, 2010SummaryThe aim of this study was to examine changes in meiotic spindle morphology over time to potentially optimize timing for ICSI. Using polarized light microscopy, images of MII oocytes were captured after retrieval of oocytes in stimulated cycles at six time intervals in culture: 36–36.5 h, 36.5–37.0 h, 38–38.5 h, 39–39.5 h, 40–40.5 h and 40.5–41 h
Suha, Kilani +2 more
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Meiotic spindle mechanics: Sensing a disturbance in the force
Current BiologyMolecular motor proteins are important mechanical regulators of many cellular processes, yet measuring their force production in cells has been a challenge. A new paper describes the first FRET-based sensor to measure motor forces during meiotic cell division.
Amila, Šemić, Jason, Stumpff
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Numb regulates meiotic spindle organisation in mouse oocytes
Reproduction, Fertility and Development, 2010Numb is an adaptor protein that controls the fate of cells in different species through asymmetrical inheritance by sibling cells during division. It has been investigated extensively in mitosis, mostly in neural progenitor cells, but its function in meiosis remains unknown.
H, Lv +6 more
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Meiotic spindle checkpoints for assessment of aneuploid oocytes
Cytogenetic and Genome Research, 2005The spindle assembly checkpoint suspends cell cycle progression if improperly aligned chromosomes are detected at metaphase. Evolutionarily conserved kinetochore-associated proteins are believed to be key elements of this regulatory pathway. A breakdown in checkpoint function could bring about genomic instability, which may be responsible for the ...
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Nature Cell Biology, 2003
Mutations in the aberrant X segragation (Axs) gene disrupt the segregation of achiasmate chromosomes during female meiosis in Drosophila melanogaster. We show that Axs encodes the founding member of an eukaryotic family of transmembrane proteins. Axs protein colocalizes with components of the endoplasmic reticulum and is present within a structure ...
Joseph, Kramer, R Scott, Hawley
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Mutations in the aberrant X segragation (Axs) gene disrupt the segregation of achiasmate chromosomes during female meiosis in Drosophila melanogaster. We show that Axs encodes the founding member of an eukaryotic family of transmembrane proteins. Axs protein colocalizes with components of the endoplasmic reticulum and is present within a structure ...
Joseph, Kramer, R Scott, Hawley
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