NuSAP4 regulates chromosome segregation in Trypanosoma brucei by promoting bipolar spindle assembly [PDF]
Communications BiologyFaithful chromosome segregation in eukaryotes requires the assembly of a bipolar spindle and the faithful attachment of kinetochores to spindle microtubules, which are regulated by various spindle-associated proteins (SAPs) that play distinct functions ...
Qing Zhou, Ziyin Li
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Proteome of oocyte spindle identifies Ccdc69 regulates spindle assembly like “band-tightening spell” [PDF]
Cellular and Molecular Life SciencesMeiotic spindle is an intricate structure and required for chromosome segregation and the proper meiotic progression during oocyte maturation, and its function is regulated by a complex network of proteins located at spindle and its peripheral region ...
Jia-Ni Guo +12 more
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RNF20 Regulates Oocyte Meiotic Spindle Assembly by Recruiting TPM3 to Centromeres and Spindle Poles
Advanced SciencePreviously a ring finger protein 20 (RNF20) is found to be essential for meiotic recombination and mediates H2B ubiquitination during spermatogenesis. However, its role in meiotic division is still unknown.
Liying Wang +11 more
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Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes [PDF]
eLifeThe spindle assembly checkpoint (SAC) temporally regulates mitosis by preventing progression from metaphase to anaphase until all chromosomes are correctly attached to the mitotic spindle.
KC Farrell, Jennifer T Wang, Tim Stearns
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CAMSAP2 is required for bridging fiber assembly to ensure mitotic spindle assembly and chromosome segregation in human epithelial Caco-2 cells. [PDF]
PLoS ONEIn mammalian epithelial cells, cytoplasmic microtubules are mainly non-centrosomal, through the functions of the minus-end binding proteins CAMSAP2 and CAMSAP3.
Naoko Nishizawa +4 more
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Scientific Reports, 2021 Phosphatidylinositol glycan anchor biosynthesis class N (PIGN) has been linked to the suppression of chromosomal instability. The spindle assembly checkpoint complex is responsible for proper chromosome segregation during mitosis to prevent chromosomal ...
Emmanuel K. Teye +9 more
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Random chromosome distribution in the first meiosis of F1 disomic substitution line 2R(2D) x rye hybrids (ABDR, 4× = 28) occurs without bipolar spindle assembly [PDF]
Comparative Cytogenetics, 2020 The assembly of the microtubule-based spindle structure in plant meiosis remains poorly understood compared with our knowledge of mitotic spindle formation.
Dina B. Loginova +2 more
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Compartmentalized control of Cdk1 drives mitotic spindle assembly
Cell Reports, 2022 Summary: During cell division, dramatic microtubular rearrangements driven by cyclin B-cdk1 (Cdk1) kinase activity mark the onset of mitosis leading to dismantling of the interphase microtubular cytoskeleton and assembly of the mitotic spindle.
Angela Flavia Serpico +3 more
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Biology Open, 2020 How oocytes assemble bipolar meiotic spindles in the absence of centrosomes as microtubule organizing centers remains poorly understood. We have used live cell imaging in Caenorhabditis elegans to investigate requirements for the nuclear lamina and for ...
Chien-Hui Chuang +3 more
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NuMA regulates mitotic spindle assembly, structural dynamics and function via phase separation
Nature Communications, 2021 Mitotic spindle assembly is required for proper cell division, but many underlying mechanisms remain unclear. Here, the authors show that NuMa undergoes liquid-liquid phase separation, condensing on spindle poles during mitotic entry and enriching ...
Mengjie Sun +7 more
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