Results 1 to 10 of about 51,274 (213)
The Spindle Assembly Checkpoint [PDF]
Current Biology, 2012 During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate chromosome segregation can be guaranteed. Accuracy requires that chromosomes become correctly attached to the microtubule spindle apparatus via their kinetochores.
Lara-Gonzalez, Pablo +2 more
openaire +2 more sources
The spindle assembly checkpoint [PDF]
Current Biology, 2008 (Current Biology 18, R391–R395; July 22, 2008)Because of an editorial mistake, Figure 1Figure 1 of this Primer shows pairs of kinetochores (indicated by pairs of yellow dots) during telophase, instead of single kinetochores as indicated in the corrected figure that appears here. The journal regrets this error.Figure 1The SAC as a synchronization device(
Varetti, Gianluca, Musacchio, Andrea
openaire +5 more sources
The elegans of spindle assembly [PDF]
Cellular and Molecular Life Sciences, 2010 The Caenorhabditis elegans one-cell embryo is a powerful system in which to study microtubule organization because this large cell assembles both meiotic and mitotic spindles within the same cytoplasm over the course of 1 h in a stereotypical manner. The fertilized oocyte assembles two consecutive acentrosomal meiotic spindles that function to reduce ...
Müller-Reichert, T. +3 more
openaire +3 more sources
Spindle Assembly Factor Protection [PDF]
Molecular Cell, 2014 In this issue, Song et al. (2014) describe how microtubules and the RAN GTPase/importin-β system collaborate to control timing of HURP action and its turnover via the anaphase promoting complex (APC)-proteasome system, thereby ensuring temporal control of late mitotic events.
Vaites, Laura L. Pontano +1 more
openaire +2 more sources
Assembly and Positioning of the Oocyte Meiotic Spindle [PDF]
Annual Review of Cell and Developmental Biology, 2018 Fertilizable eggs develop from diploid precursor cells termed oocytes. Once every menstrual cycle, an oocyte matures into a fertilizable egg in the ovary. To this end, the oocyte eliminates half of its chromosomes into a small cell termed a polar body. The egg is then released into the Fallopian tube, where it can be fertilized.
Mogessie, Binyam +2 more
openaire +6 more sources
Phospho‐regulation of mitotic spindle assembly [PDF]
Cytoskeleton, 2020 AbstractThe assembly of the bipolar mitotic spindle requires the careful orchestration of a myriad of enzyme activities like protein posttranslational modifications. Among these, phosphorylation has arisen as the principle mode for spatially and temporally activating the proteins involved in early mitotic spindle assembly processes. Here, we review key
Joseph Y. Ong +2 more
openaire +4 more sources
The spindle assembly checkpoint and speciation
PeerJ, 2020 A mechanism is proposed by which speciation may occur without the need to postulate geographical isolation of the diverging populations. Closely related species that occupy overlapping or adjacent ecological niches often have an almost identical genome but differ by chromosomal rearrangements that result in reproductive isolation.
Jackson, Robert C, Mistry, Hitesh B
openaire +6 more sources
Metaphase Spindle Assembly [PDF]
Biology, 2017 A microtubule-based bipolar spindle is required for error-free chromosome segregation during cell division. In this review I discuss the molecular mechanisms required for the assembly of this dynamic micrometer-scale structure in animal cells.
openaire +3 more sources
Mechanisms of Mitotic Spindle Assembly [PDF]
Annual Review of Biochemistry, 2016 Life depends on cell proliferation and the accurate segregation of chromosomes, which are mediated by the microtubule (MT)-based mitotic spindle and ∼200 essential MT-associated proteins. Yet, a mechanistic understanding of how the mitotic spindle is assembled and achieves chromosome segregation is still missing.
openaire +2 more sources
The mechanism of spindle assembly [PDF]
The Journal of Cell Biology, 2004 Recent work has provided new insights into the mechanism of spindle assembly. Growing evidence supports a model in which the small GTPase Ran plays a central role in this process. Here, we examine the evidence for the existence of a RanGTP gradient around mitotic chromosomes and some controversial data on the role that chromosomes play in spindle ...
Oliver J. Gruss, Isabelle Vernos
openaire +1 more source