Results 11 to 20 of about 58,631 (285)
Metaphase Spindle Assembly [PDF]
Biology, 2017 A microtubule-based bipolar spindle is required for error-free chromosome segregation during cell division. In this review I discuss the molecular mechanisms required for the assembly of this dynamic micrometer-scale structure in animal cells.
Tarun M. Kapoor
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The Spindle Assembly Checkpoint [PDF]
Current Biology, 2012 During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate chromosome segregation can be guaranteed. Accuracy requires that chromosomes become correctly attached to the microtubule spindle apparatus via their kinetochores.
Lara-Gonzalez, Pablo +2 more
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Mechanisms of Mitotic Spindle Assembly [PDF]
Annual Review of Biochemistry, 2016 Life depends on cell proliferation and the accurate segregation of chromosomes, which are mediated by the microtubule (MT)-based mitotic spindle and ∼200 essential MT-associated proteins. Yet, a mechanistic understanding of how the mitotic spindle is assembled and achieves chromosome segregation is still missing.
Petry, Sabine
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Mechanism of spindle assembly in Schizosaccharomyces pombe - The role of microtubule pivoting in spindle assembly [PDF]
, 2016 At the onset of cell division microtubules growing from spindle pole bodies (SPB) interact with each other to form the mitotic spindle enabling proper chromosome positioning and segregation. However, the exact mechanism of microtubule dynamics and microtubule associated proteins (MAPs) underlying spindle assembly is still not well understood.
Winters, Lora, Winters, L.
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The elegans of spindle assembly [PDF]
Cellular and Molecular Life Sciences, 2010 The Caenorhabditis elegans one-cell embryo is a powerful system in which to study microtubule organization because this large cell assembles both meiotic and mitotic spindles within the same cytoplasm over the course of 1 h in a stereotypical manner. The fertilized oocyte assembles two consecutive acentrosomal meiotic spindles that function to reduce ...
Müller-Reichert, T. +3 more
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The spindle assembly checkpoint [PDF]
Current Biology, 2008 (Current Biology 18, R391–R395; July 22, 2008)Because of an editorial mistake, Figure 1Figure 1 of this Primer shows pairs of kinetochores (indicated by pairs of yellow dots) during telophase, instead of single kinetochores as indicated in the corrected figure that appears here. The journal regrets this error.Figure 1The SAC as a synchronization device(
Varetti, Gianluca, Musacchio, Andrea
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Meiotic regulation of TPX2 protein levels governs cell cycle progression in mouse oocytes. [PDF]
PLoS ONE, 2008 Formation of female gametes requires acentriolar spindle assembly during meiosis. Mitotic spindles organize from centrosomes and via local activation of the RanGTPase on chromosomes.
Stéphane Brunet +7 more
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Spindle Assembly Factor Protection [PDF]
Molecular Cell, 2014 In this issue, Song et al. (2014) describe how microtubules and the RAN GTPase/importin-β system collaborate to control timing of HURP action and its turnover via the anaphase promoting complex (APC)-proteasome system, thereby ensuring temporal control of late mitotic events.
Vaites, Laura L. Pontano +1 more
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RNA stimulates Aurora B kinase activity during mitosis. [PDF]
PLoS ONE, 2014 Accurate chromosome segregation is essential for cell viability. The mitotic spindle is crucial for chromosome segregation, but much remains unknown about factors that regulate spindle assembly.
Ashwini Jambhekar +3 more
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Kinesin-5 Eg5 is essential for spindle assembly and chromosome alignment of mouse spermatocytes
Cell Division, 2020 Background Microtubule organization is essential for bipolar spindle assembly and chromosome segregation, which contribute to genome stability. Kinesin-5 Eg5 is known to be a crucial regulator in centrosome separation and spindle assembly in mammalian ...
Zhen-Yu She +7 more
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