Results 41 to 50 of about 58,631 (285)

Fission yeast bub1 is a mitotic centromere protein essential for the spindle checkpoint and the preservation of correct ploidy through mitosis [PDF]

, 1998
The spindle checkpoint ensures proper chromosome segregation by delaying anaphase until all chromosomes are correctly attached to the mitotic spindle.
Javerzat, Jean-Paul, Javerzat, J P, Bernard, P, Hardwick, K.G., Hardwick, Kevin, Bernard, Pascal, Pascal Bernard, Jean-Paul Javerzat, Kevin Hardwick   +8 more
core   +1 more source

Bub1 is a fission yeast kinetochore scaffold protein, and is sufficient to recruit other spindle checkpoint proteins to ectopic sites on chromosomes [PDF]

, 2007
The spindle checkpoint delays anaphase onset until all chromosomes have attached in a bi-polar manner to the mitotic spindle. Mad and Bub proteins are recruited to unattached kinetochores, and generate diffusible anaphase inhibitors.
Rischitor, Patricia E, Kevin G Hardwick, Rischitor Patricia E., Patricia E Rischitor, May, Karen M, Hardwick Kevin G., Hardwick, Kevin G, Karen M May, May Karen M.   +8 more
core   +1 more source

New mitotic regulators released from chromatin

Frontiers in Oncology, 2013
Faithful action of the mitotic spindle segregates duplicated chromosomes into daughter cells. Perturbations of this process result in chromosome mis-segregation, leading to chromosomal instability and cancer development.
Hideki eYokoyama, Oliver eGruss
doaj   +1 more source

Checkpoint proteins come under scrutiny [PDF]

, 2013
Details are emerging of the interactions between the kinetochore and various spindle checkpoint proteins that ensure that sister chromatids are equally divided between daughter cells during cell ...
Jonathan BA Millar, Mora-Santos, Maria, Millar, Jonathan B. A., Maria Mora-Santos   +3 more
core   +1 more source

Bub1 kinase in the regulation of mitosis

Animal Cells and Systems, 2021
Accurate chromosome segregation is required for cell survival and organismal development. During mitosis, the spindle assembly checkpoint acts as a safeguard to maintain the high fidelity of mitotic chromosome segregation by monitoring the attachment of ...
Taekyung Kim, Anton Gartner
doaj   +1 more source

Spindle assembly checkpoint silencing and beyond [PDF]

Cell Cycle, 2016
The Spindle Assembly Checkpoint (SAC) prevents anaphase onset in the absence of kinetochore-microtubule attachment, ensuring that cells with unattached kinetochores do not proceed into anaphase.
Michael, Bokros, Yanchang, Wang
openaire   +2 more sources

On the regulation of chromosome segregation in human cells : implications of Bub1 Kinase inhibition during cell division [PDF]

, 2015
The maintenance of correct chromosome number (euploidy) during cell division is essential for health. Loss of euploidy is observed in most cancers and is linked to tumorigenesis.
Baron, Anna
core   +1 more source

Roles of Tubulin Concentration during Prometaphase and Ran-GTP during Anaphase of Caenorhabditis elegans Meiosis

Life Science Alliance
Tubulin dimers concentrate within an ER spindle envelope because cytoplasmic organelles outside the envelope occupy significant volume. In many animal species, the oocyte meiotic spindle, which is required for chromosome segregation, forms without ...
Ting Gong, Karen L McNally, Siri Konanoor, Alma Peraza, Cynthia Bailey, Stefanie Redemann, Francis J McNally   +6 more
doaj   +1 more source

Establishment and mitotic characterization of new Drosophila acentriolar cell lines from DSas-4 mutant

Biology Open, 2013
Summary In animal cells the centrosome is commonly viewed as the main cellular structure driving microtubule (MT) assembly into the mitotic spindle apparatus.
Nicolas Lecland, Alain Debec, Audrey Delmas, Sara Moutinho-Pereira, Nicolas Malmanche, Anais Bouissou, Clémence Dupré, Aimie Jourdan, Brigitte Raynaud-Messina, Helder Maiato, Antoine Guichet   +10 more
doaj   +1 more source

C. elegans CLASP/CLS-2 negatively regulates membrane ingression throughout the oocyte cortex and is required for polar body extrusion.

PLoS Genetics, 2020
The requirements for oocyte meiotic cytokinesis during polar body extrusion are not well understood. In particular, the relationship between the oocyte meiotic spindle and polar body contractile ring dynamics remains largely unknown.
Aleesa J Schlientz, Bruce Bowerman
doaj   +1 more source