Results 61 to 70 of about 1,379,565 (255)
Mitotic Spindle Assembly in Land Plants: Molecules and Mechanisms
Biology, 2017 In textbooks, the mitotic spindles of plants are often described separately from those of animals. How do they differ at the molecular and mechanistic levels?
Moé Yamada, Gohta Goshima
doaj +1 more source
Nucleus, 2020 Xenopus egg extracts are a powerful in vitro tool for studying complex biological processes, including nuclear reconstitution, nuclear membrane and pore assembly, and spindle assembly.
Matthew S. Nord +5 more
doaj +1 more source
OsPRD2 is essential for double-strand break formation, but not spindle assembly during rice meiosis
Frontiers in Plant Science, 2023 Meiotic recombination starts with the programmed formation of double-strand breaks (DSB) in DNA, which are catalyzed by SPO11, a type II topoisomerase that is evolutionarily conserved, and several other accessary proteins. Homologs of MEIOSIS INHIBITOR 4
Chong Wang +6 more
doaj +1 more source
Characterisation of the spindle assembly checkpoint in mammalian oocytes [PDF]
, 2009 Vogt E-J. Characterisation of the spindle assembly checkpoint in mammalian oocytes.
Vogt, Edgar-John
core
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Some assembly required: Redefining the mitotic checkpoint
Molecular & Cellular Oncology, 2017 The spindle assembly checkpoint (also known as the spindle or mitotic checkpoint) is a surveillance system that ensures fidelity of chromosome segregation.
John C. Meadows, Jonathan B. A. Millar
doaj +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Aging-related aneuploidy is associated with mitochondrial imbalance and failure of spindle assembly
Cell Death Discovery, 2023 Despite aging is closely linked to increased aneuploidy in the oocytes, the mechanism of how aging affects aneuploidy remains largely elusive. Here, we applied single-cell parallel methylation and transcriptome sequencing (scM&T-seq) data from the aging ...
Fa-Li Zhang +6 more
doaj +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Nature CommunicationsDespite drastic cellular changes during cleavage, a mitotic spindle assembles in each blastomere to accurately segregate duplicated chromosomes. Mechanisms of mitotic spindle assembly have been extensively studied using small somatic cells.
Ai Kiyomitsu +6 more
doaj +1 more source