Results 51 to 60 of about 58,631 (285)

The kinesin-12 Kif15 is a processive track-switching tetramer [PDF]

, 2014
Kinesin-12 motors are a little studied branch of the kinesin superfamily with the human protein (Kif15) implicated in spindle mechanics and chromosome movement.
McHugh, Toni, Singleton, Martin R., Carter, Nicholas J., Toni McHugh, Hauke Drechsler, Nicholas J Carter, Drechsler, Hauke, McAinsh, Andrew D., Martin R Singleton, Andrew D McAinsh   +9 more
core   +1 more source

Meiosis-specific stable binding of augmin to acentrosomal spindle poles promotes biased microtubule assembly in oocytes.

PLoS Genetics, 2013
In the oocytes of many animals including humans, the meiotic spindle assembles without centrosomes. It is still unclear how multiple pathways contribute to spindle microtubule assembly, and whether they are regulated differently in mitosis and meiosis ...
Nathalie Colombié, A Agata Głuszek, Ana M Meireles, Hiroyuki Ohkura   +3 more
doaj   +1 more source

A Balance between Nuclear and Cytoplasmic Volumes Controls Spindle Length. [PDF]

PLoS ONE, 2016
Proper assembly of the spindle apparatus is crucially important for faithful chromosome segregation during anaphase. Thanks to the effort over the last decades, we have very detailed information about many events leading to spindle assembly and ...
Lucia Novakova, Kristina Kovacovicova, Thanh Quang Dang-Nguyen, Martin Sodek, Michal Skultety, Martin Anger   +5 more
doaj   +1 more source

Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2 [PDF]

, 2004
Mitotic kinases of the Polo and Aurora families are key regulators of chromosome segregation and cytokinesis. Here, we have investigated the role of MKlp1 and MKlp2, two vertebrate mitotic kinesins essential for cytokinesis, in the spatial regulation of ...
Erich A. Nigg, Francis A. Barr, Barr, FA, Neef, Rüdiger, Nigg, EA, Rüdiger Neef, Gruneberg, Ulrike, Honda, R, Ulrike Gruneberg, Nigg, Erich A., Neef, R, Reiko Honda, Honda, Reiko, Barr, Francis A.   +13 more
core   +1 more source

HSP70 is required for the proper assembly of pericentriolar material and function of mitotic centrosomes

Cell Division, 2019
Background At the onset of mitosis, the centrosome expands and matures, acquiring enhanced activities for microtubule nucleation and assembly of a functional bipolar mitotic spindle.
Chieh-Ting Fang, Hsiao-Hui Kuo, Shao-Chun Hsu, Ling-Huei Yih   +3 more
doaj   +1 more source

Mitotic spindle assembly around RCC1-coated beads in Xenopus egg extracts. [PDF]

PLoS Biology, 2011
During cell division the genetic material on chromosomes is distributed to daughter cells by a dynamic microtubule structure called the mitotic spindle.
David Halpin, Petr Kalab, Jay Wang, Karsten Weis, Rebecca Heald   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

An ATM and ATR dependent checkpoint inactivates spindle assembly by targeting CEP63 [PDF]

, 2010
The effects of ATM and ATR signalling induced by chromosomal breakage have been described extensively in modulating cell cycle progression up to the onset of mitosis.
Smith, E.A.
core  

Borealin : a novel chromosomal passenger required for stability of the bipolar mitotic spindle [PDF]

, 2004
The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Here, we describe Borealin, a novel member of the complex.
Erich A. Nigg, Ana Carvalho, Dietlind L. Gerloff, Reto Gassmann, Sandrine Ruchaud, Nigg, E. A., Henzing, Alexander J., Nigg, Erich A., Hudson, D. E., Damien F. Hudson, Reiko Honda, Honda, Reiko, Gassmann, Reto, Gassmann, R., Ruchaud, Sandrine, Earnshaw, William C., Hudson, Damien F., Carvalho, Ana, Ruchaud, S., Honda, R., Gerloff, D. L., Earnshaw, W. C., Alexander J. Henzing, William C. Earnshaw, Henzing, A. J., Carvalho, A., Gerloff, Dietlind L.   +26 more
core   +1 more source

OsPRD2 is essential for double-strand break formation, but not spindle assembly during rice meiosis

Frontiers in Plant Science, 2023
Meiotic recombination starts with the programmed formation of double-strand breaks (DSB) in DNA, which are catalyzed by SPO11, a type II topoisomerase that is evolutionarily conserved, and several other accessary proteins. Homologs of MEIOSIS INHIBITOR 4
Chong Wang, Chong Wang, Shuying Qu, Jie Zhang, Ming Fu, Xiaofei Chen, Wanqi Liang   +6 more
doaj   +1 more source