Results 81 to 90 of about 51,274 (213)

Hypoxia and the cytoskeleton

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Correction: PIGN spatiotemporally regulates the spindle assembly checkpoint proteins in leukemia transformation and progression. [PDF]

open access: yesSci Rep
Teye EK   +9 more
europepmc   +1 more source

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise   +2 more
wiley   +1 more source

Scheduling optimization of optical lens polishing

open access: yesInternational Transactions in Operational Research, Volume 33, Issue 6, Page 3744-3768, November 2026.
Abstract Optical systems have achieved notable progress in focusing and imaging technologies; however, manual grinding remains indispensable, resulting in elevated costs, extended timelines, and inefficiencies. These difficulties are compounded by operational constraints, uneven machine utilization, and risks of order delays and escalating expenses ...
Tzu‐Chin Lin, Bertrand M. T. Lin
wiley   +1 more source

Drugst.One DREAM—Drug repurposing through expert annotation and modification

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 13, Page 3503-3516, July 2026.
Background and Purpose Complex diseases often lack an actionable understanding of their underlying causal biological mechanisms, which leads to treating symptoms rather than causes. Network and systems medicine define disease mechanisms through disease‐associated genes, their encoded proteins and their protein–protein interactions (PPIs), thus forming ...
Lisa M. Spindler   +8 more
wiley   +1 more source

The T Cell Receptor: Molecular Sensor, Therapeutic Mediator and Probabilistic Driver of Adaptive Immunity

open access: yesImmunological Reviews, Volume 340, Issue 1, July 2026.
ABSTRACT Advances in high‐throughput sequencing, single‐cell profiling, and genome engineering have transformed the study of T cell receptors (TCRs), enabling the identification and functional interrogation of antigen‐specific repertoires at an unprecedented scale.
Kilian Schober
wiley   +1 more source

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