Results 81 to 90 of about 58,631 (285)
On the assembly of the mitotic spindle, bistability and hysteresis
Cellular and Molecular Life Sciences, 2023 AbstractDuring cell division, the transition from interphase to mitosis is dictated by activation of the cyclin B-cdk1 (Cdk1) complex, master mitotic kinase. During interphase, Cdk1 accumulates in an inactive state (pre-Cdk1). When Cdk1 overcomes a certain threshold of activity upon initial activation of pre-Cdk1, then the stockpiled pre-Cdk1 is ...
Serpico, Angela Flavia +2 more
openaire +3 more sources
Flexible Wide Bandgap Electrode System for In situ Cell Sensing and Irreversible Electroporation
Advanced Materials Interfaces, EarlyView.The paper reports the design and wafer‐level microfabrication of a long‐lived, flexible 3C‐SiC electrode capable of sensitive and in situ cell sensing, as well as electroporation ablation. The work demonstrates a biocompatible and durable electrode platform that can perform reliable electrical interfacing with biological tissues over extended periods ...
Minh Anh Huynh +3 more
wiley +1 more source
Investigating the cellular and molecular mechanisms involved in establishing and maintaining centrosome asymmetry in Drosophila neuroblasts [PDF]
, 2015 Centrosome asymmetry has been implicated in stem cell fate maintenance in both flies and vertebrates. Drosophila neuroblasts, the neural precursors of the fly’s central nervous system, contain molecularly and physically asymmetric centrosomes.
Nair, Anjana Ramdas
core +1 more source
Cell Division, 2008 During mitosis, correct bipolar chromosome attachment to the mitotic spindle is an essential prerequisite for the equal segregation of chromosomes. The spindle assembly checkpoint can prevent chromosome segregation as long as not all chromosome pairs ...
Maia André F +2 more
doaj +1 more source
Axin-1 Regulates Meiotic Spindle Organization in Mouse Oocytes. [PDF]
PLoS ONE, 2016 Axin-1, a negative regulator of Wnt signaling, is a versatile scaffold protein involved in centrosome separation and spindle assembly in mitosis, but its function in mammalian oogenesis remains unknown.
Xiao-Qin He +12 more
doaj +1 more source
SnapShot: Motor Proteins in Spindle Assembly
Cell, 2008 Klp59C (fly)MCAK (frog, human)MONOPOLAR SPINDLEHALF SPINDLELONGER SPINDLELOSS OF CENTROSOMESSPLIT/SPLAYED POLESKINETOCHORE MISALIGNMENT,MISORIENTATIONMISALIGNED CHROMOSOME ARMSBENT SPINDLECrosslinks MTs and slides antiparallel MTs outwardSlides MTs poleward;exerts antagonizing forceagainst Kinesin-5Depolymerizes MTs atspindle polesSlides MTs poleward ...
Loughlin, Rose +2 more
openaire +2 more sources
Advanced Materials Technologies, EarlyView.Multi‐million cycle reliability for liquid metal stretchable electronics is achieved through a continuous cycle of mechanical testing, failure mode and mechanism analysis and implementing subsequent mitigation strategies. ABSTRACT Stretchable electronics that combine mechanical compliance with reliable electrical performance are essential for ...
Lennert Purnal +8 more
wiley +1 more source
Spindle Assembly: Kinesin-5 Is in Control [PDF]
Current Biology, 2008 Kinesin-5 is essential in many species for the formation of a bipolar spindle. Although bipolar tetramers were known to crossbridge pairs of microtubules, the mechanism for organizing spindles was unclear. However, new experiments have revealed unique properties of kinesin-5, including some associated with the tail domain, that provide clues as to how ...
openaire +2 more sources
Advanced Science, EarlyView.Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia +17 more
wiley +1 more source
On the regulation of centriole duplication in human cells : exploring the interactions of polo-like kinase 4 with the centrosomal proteins Cep192 and STIL [PDF]
, 2015 Centrioles duplicate once in each cell cycle to give rise to two centrosomes that form the spindle poles during mitosis. Aberrant centriole duplication can result in the formation of supernumerary centrosomes, leading to incorrect spindle assembly and ...
Gabryjonczyk, Anna-Maria
core +1 more source