Results 21 to 30 of about 1,379,565 (255)

Role of spindle assembly checkpoint proteins in gametogenesis and embryogenesis [PDF]

Frontiers in Cell and Developmental Biology
Brian J North, Renju Pun
exaly   +2 more sources

Meiotic regulation of TPX2 protein levels governs cell cycle progression in mouse oocytes. [PDF]

PLoS ONE, 2008
Formation of female gametes requires acentriolar spindle assembly during meiosis. Mitotic spindles organize from centrosomes and via local activation of the RanGTPase on chromosomes.
Stéphane Brunet, Julien Dumont, Karen W Lee, Kazuhisa Kinoshita, Pascale Hikal, Oliver J Gruss, Bernard Maro, Marie-Hélène Verlhac   +7 more
doaj   +1 more source

RNA stimulates Aurora B kinase activity during mitosis. [PDF]

PLoS ONE, 2014
Accurate chromosome segregation is essential for cell viability. The mitotic spindle is crucial for chromosome segregation, but much remains unknown about factors that regulate spindle assembly.
Ashwini Jambhekar, Amy B Emerman, Caterina T H Schweidenback, Michael D Blower   +3 more
doaj   +1 more source

Length-dependent anisotropic scaling of spindle shape [PDF]

, 2014
Spindle length varies dramatically across species and during early development to segregate chromosomes optimally. Both intrinsic factors, such as regulatory molecules, and extrinsic factors, such as cytoplasmic volume, determine spindle length scaling ...
Sébastien Besson, Sarah Young, Welburn, Julie P I, Julie P. I. Welburn, Young, Sarah, Besson, Sébastien   +5 more
core   +1 more source

BubR1 is frequently repressed in acute myeloid leukemia and its re-expression sensitizes cells to antimitotic therapy

Haematologica, 2013
Spindle poison-based therapy is of only limited benefit in acute myeloid leukemia while lymphoblastic leukemia/lymphoma responds well. In this study, we demonstrated that the spindle assembly checkpoint protein BubR1 was down-regulated in the vast ...
Dominik Schnerch, Andrea Schmidts, Marie Follo, Josefina Udi, Julia Felthaus, Dietmar Pfeifer, Monika Engelhardt, Ralph Wäsch   +7 more
doaj   +1 more source

Kinesin-5 Eg5 is essential for spindle assembly and chromosome alignment of mouse spermatocytes

Cell Division, 2020
Background Microtubule organization is essential for bipolar spindle assembly and chromosome segregation, which contribute to genome stability. Kinesin-5 Eg5 is known to be a crucial regulator in centrosome separation and spindle assembly in mammalian ...
Zhen-Yu She, Ning Zhong, Kai-Wei Yu, Yu Xiao, Ya-Lan Wei, Yang Lin, Yue-Ling Li, Ming-Hui Lu   +7 more
doaj   +1 more source

Human TPX2 is required for targeting Aurora-A kinase to the spindle [PDF]

, 2002
Aurora-A is a serine-threonine kinase implicated in the assembly and maintenance of the mitotic spindle. Here we show that human Aurora-A binds to TPX2, a prominent component of the spindle apparatus.
Roman Körner, Erich A. Nigg, Oliver J. Gruss, Silljé, Herman H. W., Thomas A. Kufer, Kufer, Thomas A., Gruss, Oliver J., Nigg, Erich A., Patrick Meraldi, Körner, Roman, Meraldi, Patrick, Herman H.W. Silljé   +11 more
core   +1 more source

Dual pathway spindle assembly increases both the speed and the fidelity of mitosis [PDF]

, 2011
Roughly half of all animal somatic cell spindles assemble by the classical prophase pathway, in which the centrosomes separate ahead of nuclear envelope breakdown (NEBD).
Robert A. Cross, Kaseda, Kuniyoshi, Cross, R. A., Kuniyoshi Kaseda, McAinsh, Andrew D., Andrew D. McAinsh   +5 more
core   +1 more source

The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability [PDF]

, 2009
Myc-induced SUN domain–containing protein (Misu or NSun2) is a nucleolar RNA methyltransferase important for c-Myc–induced proliferation in skin, but the mechanisms by which Misu contributes to cell cycle progression are unknown.
Michaela Frye, Benavente, Sandra Blanco, Elisabete Nascimento, Kurowski, Agata, Nascimento, Elisabete, Hussain, Shobbir, Ilaria Dragoni, Dragoni, Ilaria, Gillich, Astrid, Shobbir Hussain, Sandra Blanco Benavente, Astrid Gillich, Frye, Michaela, Peter Humphreys, Humphreys, Peter, Agata Kurowski   +15 more
core   +1 more source

Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A [PDF]

, 2013
Anaphase central spindle formation is controlled by the microtubule-stabilizing factor PRC1 and the kinesin KIF4A. We show that an MKlp2-dependent pool of Aurora B at the central spindle, rather than global Aurora B activity, regulates KIF4A accumulation
Erich A. Nigg, Francis A. Barr, Baron, Ryan D., Ricardo Nunes Bastos, Ryan D. Baron, Gruneberg, Ulrike, Gandhi, Sapan R., Nunes Bastos, Ricardo, Ulrike Gruneberg, Nigg, Erich A., Sapan R. Gandhi, Barr, Francis A.   +11 more
core   +1 more source