Results 231 to 240 of about 133,463 (299)

MEN1 Deficiency Drives Lung Cancer Progression via Activation of MMP10‐Mediated Angiogenesis

Cancer Science, EarlyView.
MEN1 deficiency promotes JunD‐mediated upregulation of MMP10 expression, which cleaves pro‐HB‐EGF and activates endothelial EGFR. This triggers the PI3K/Akt and MEK/ERK signaling pathways, thereby driving angiogenesis and tumor progression. MMP10 inhibitor treatment blocks this cleavage, suppresses EGFR signaling, and thereby delays malignant ...
Chengyu Wei, Xiangyu Liu, Shimin Hu, Xiaodie Shen, Yingli Liu, Xinxin Qin, Ye Zhou, Jianqi Zheng, Bingke Tian, Jingfang Hong, Yongxia Song, Di Wang, Linlin Peng, Jinxia Ding, Fang Wang, Hui Zhang, Shihao Zhang, Huan Qiu   +17 more
wiley   +1 more source

MEK Inhibitors and Toll-like Receptor Signaling: Implications for Infection and Inflammation. [PDF]

Int J Mol Sci
Planz O.
europepmc   +1 more source

Current Molecular-Targeted Therapies in Melanoma and Their Mechanism of Resistance. [PDF]

Cancers (Basel)
Bahari R, Nguyen M, Sohail N, Lopez S, Saravanaguru Vasanthi S, Amin J, Ramaswami D, Kapetaneas G, Karne R, Altayeh U, Rodgers KJ, Mehta AP, Puri N.   +12 more
europepmc   +1 more source

tRNA‐Derived Small RNAs in Digestive Cancers: From Translational Regulation to Immune and Extracellular Communication

Cancer Science, EarlyView.
tRNA‐derived small RNAs (tsRNAs) function in digestive cancers across three scales: intracellular translational and metabolic control, extracellular vesicle–mediated immune remodeling, and systemic and host–microbe communication. This review organizes these mechanisms by evidence strength, from well‐established intracellular roles to emerging ...
Wang Xitan, Li Han
wiley   +1 more source

Additive effect of Ruta graveolens bioactive phytoconstituents and cisplatin through PKC/MEK/ERK pathway in glioblastoma. [PDF]

Mol Ther Oncol
Romano G, Morgera V, Pezone A, Messina S, Rosa P, Iovinella M, Ciniglia C, Gentile MT, Porcellini A, Feola A.   +9 more
europepmc   +2 more sources

Intratumoural plasma cells mediate a pro-inflammatory response to kinase inhibition and successful immune checkpoint blockade therapy in malignant peripheral nerve sheath tumours. [PDF]

EBioMedicine
Lingo JJ, Reis R, Koyas A, Voigt E, Zacharias ZR, Allamargot C, Hornick EL, Raygoza Garay JA, Kaemmer CA, Elias EC, Jabbari A, Wilhelm CR, Boyden AW, Karandikar NJ, Breheny P, Meyerholz DK, Dodd RD, Houtman JCD, Darbro BW, Quelle DE.   +19 more
europepmc   +1 more source

m6A‐Mediated Stabilization of MRPS23 Drives NSCLC Progression Via HSPA8 and ERK Signaling Modulation

Cancer Science, EarlyView.
MRPS23 mRNA is m6A‐methylated by WTAP and stabilized by IGF2BP3, leading to increased MRPS23 protein. MRPS23 physically interacts with HSPA8, and this interaction is functionally associated with activation of the RAS–RAF–MEK–ERK pathway, ultimately promoting NSCLC cell proliferation and tumor progression.
Sihong Le, Yitao Le, Xianshen Sha, Feng Qiu, Ling Zhang   +4 more
wiley   +1 more source

HRAS promotes mutant NRAS-driven transformation with codon and allele specificity. [PDF]

Sci Signal
Lee H, Hughes JM, LaMorte JP, Finniff BA, Binette P, Gunasekara SK, Covas A, Wall VE, Esposito D, Wilkerson MD, Yohe ME, Kortum RL.   +11 more
europepmc   +1 more source

Genotype‐Informed Whole‐Animal Kinome Screening Reveals Shared Kinase Vulnerabilities Across Driver Contexts in PDAC

Cancer Science, EarlyView.
Overview of experimental workflow and key findings. Clinically prevalent 2‐hit and 3‐hit PDAC genotypes were first modeled in Drosophila to enable kinome‐wide genetic screening. Candidate therapeutic targets were prioritized using human tumor expression data and pathway enrichment analyses.
Han Hai, Takako Ooshio, Hui Jiang, Taku Kimura, Yusuke Satoh, Soichiro Hata, Taiga Hirata, Jiayi Liu, Tongwei Liu, Ryodai Yamamura, Masahiro Sonoshita   +10 more
wiley   +1 more source

Disease Stabilization with MEK Inhibitors in NF1-Associated Plexiform Neurofibromas: A Systematic Review and Meta-Analysis with Subgroup Analyses by Age and Study Design. [PDF]

CNS Drugs
Sanikommu S, Santos AN, Dawoud BM, Levy AS, Komotar RJ, Lu VM.   +5 more
europepmc   +1 more source