Results 201 to 210 of about 130,782 (308)

RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF‐β signaling

The FEBS Journal, EarlyView.
TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior, Maria Anastasia Doumani, Hao Fu, Jelle van den Bor, Olof Idevall‐Hagren, Aristidis Moustakas   +5 more
wiley   +1 more source

Anti-tumor efficacy of RAF/MEK inhibitor VS6766 in KRAS-mutated colorectal cancer cells. [PDF]

Cancer Chemother Pharmacol
Zhu H, Yan G, Ma J, Zhang B, Yan Y, Zhu L, Dong R, Lin N, Tan B.   +8 more
europepmc   +1 more source

Arctic lake trout (Salvelinus namaycush) show evidence of seasonal acclimation of cardiac adrenergic sensitivity but not heat tolerance

Journal of Fish Biology, EarlyView.
Abstract Many Arctic fishes experience prolonged periods of extreme cold and large thermal variation over both rapid and seasonal time scales which challenge critical physiological functions. In the central Canadian Arctic, we caught wild adult lake trout (Salvelinus namaycush) acclimatized to winter and summer temperatures to determine the extent to ...
Emily P. Williams, Les N. Harris, Jean‐Sébastien Moore, Ella K. Middleton, Shira A. Berkelhammer, Ben Speers‐Roesch, Matthew J. H. Gilbert   +6 more
wiley   +1 more source

Molecular Evidence Supporting MEK Inhibitor Therapy in NF1 Pseudarthrosis. [PDF]

J Bone Joint Surg Am
Paria N, Oxendine I, Podeszwa D, Wassell M, Cornelia R, Wise CA, Rios JJ.   +6 more
europepmc   +1 more source

The Evolving Landscape of CHD Genetics: A Contemporary Guide to Genetic Testing and Management

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Congenital heart disease (CHD) is the most common birth defect, affecting an estimated 9.4/1000 infants globally. The genetics of CHD is complex, with most cases thought to have multifactorial aetiology, implicating both genetic and environmental factors.
Bridget R. O'Malley, Gary F. Sholler, Janine Smith, Gillian M. Blue   +3 more
wiley   +1 more source

Sensitivity to immune checkpoint inhibitors in BRAF/MEK inhibitor refractory melanoma. [PDF]

J Immunother Cancer
Patel RP, Lim LRJ, Saleh R, Schenk D, Lee MK, Lelliott E, Rao AD, Arabi S, Smith L, Trigos AS, Haynes N, McArthur GA, Sheppard KE.   +12 more
europepmc   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Editorial expression of concern: ERRα suppression enhances the cytotoxicity of the MEK inhibitor trametinib against colon cancer cells. [PDF]

J Exp Clin Cancer Res
Zhou S, Xia H, Xu H, Tang Q, Nie Y, Gong QY, Bi F.   +6 more
europepmc   +1 more source

Co-operative epigenetic remodelling by Setd2 deficiency and Kras mutation drives juvenile myelomonocytic leukaemia development and MEK inhibitor sensitivity. [PDF]

Br J Haematol
Munyurangabo G, Zhang L, Zhou Y, Zhang P, Yu X, Qu D, Yang D, Ren X, Liu H, Wu Y, Kong G, Yang Y.   +11 more
europepmc   +1 more source

The Wheat CRK‐RLCK‐MAPKs Signalling Module Confers High‐Temperature All‐Stage Resistance to Stripe Rust

Plant Biotechnology Journal, EarlyView.
ABSTRACT As global warming continues, rising temperatures significantly alter the interactions between wheat and the stripe rust pathogen Puccinia striiformis f. sp. tritici (Pst). Utilising high‐temperature all‐stage (HTAS) resistance to Pst is a novel strategy for breeding climate and disease resilient wheat cultivars.
Yifeng Shi, Yue Xu, Hai Li, Meng Fu, Xu Liu, Yuxiang Li, Xiaoping Hu   +6 more
wiley   +1 more source