Hedgehog Pathway Activation Alters Ciliary Signaling in Primary Hypothalamic Cultures [PDF]
, 2019 Primary cilia dysfunction has been associated with hyperphagia and obesity in both ciliopathy patients and mouse models of cilia perturbation. Neurons throughout the brain possess these solitary cellular appendages, including in the feeding centers of ...
Antonellis, Patrick J. +7 more
core +1 more source
Indian Journal of Pathology and Microbiology, 2014 Background: Dematiaceous fungi appear brown in tissue section due to melanin in their cell walls. When the brown color is not seen on routine H and E and culture is not available, differentiation of dematiaceous fungi from other fungi is difficult on ...
Challa Sundaram +3 more
doaj +1 more source
SCD5 restored expression favors differentiation and epithelial-mesenchymal reversion in advanced melanoma [PDF]
, 2018 Our previous data supported a role for the Stearoyl-CoA desaturase (SCD5) in protection against malignancy, whereby it appears to functionally modify tumor stroma impairing tumor spread.
Bellenghi, Maria +8 more
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SPECTRAL PROPERTIES OF TWO WATER-SOLUBLE MELANINS [PDF]
Biotechnologia ActaAim. The work was purposed to study the spectral properties of two types of water-soluble melanins to clarify the nature of the optical absorption and emission centers in them. Materials and methods.
V.M. Kravchenko +8 more
doaj +1 more source
Eumelanin Graphene-Like Integration: The Impact on Physical Properties and Electrical Conductivity
Frontiers in Chemistry, 2019 The recent development of eumelanin pigment-based blends integrating “classical” organic conducting materials is expanding the scope of eumelanin in bioelectronics.
Roberto Di Capua +6 more
doaj +1 more source
Assessment of melanogenesis in a pigmented human tissue-cultured skin equivalent
Indian Journal of Dermatology, 2019 Background: Organotypic tissue-cultured skin equivalents are used for a broad range of applications either as possible substitute for animal tests or for transplantation in patient-centered care.
Nadja Nicole Zoller +8 more
doaj +1 more source
SRM Journal of Research in Dental Sciences, 2014 Background and Aim: The exposure to environmental tobacco smoke (ETS) has been recognized as a strong contributor to respiratory disorders, lung cancer, peripheral vascular function and death. Increased gingival pigmentation in smokers is established. In
Shabeer Mohamed Madani, Biju Thomas
doaj +1 more source
Towards Structure-Property-Function Relationships for Eumelanin
, 2005 We discuss recent progress towards the establishment of important structure-property-function relationships in eumelanins - key functional bio-macromolecular systems responsible for photo-protection and immune response in humans, and implicated in the ...
Ben J. Powell +46 more
core +1 more source
Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse model. [PDF]
, 2017 An excessive requirement for methionine termed methionine dependence, appears to be a general metabolic defect in cancer. We have previously shown that cancer-cell growth can be selectively arrested by methionine deprivation such as with recombinant ...
Chmielowski, Bartosz +15 more
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Tumor-targeting Salmonella typhimurium A1-R combined with temozolomide regresses malignant melanoma with a BRAF-V600E mutation in a patient-derived orthotopic xenograft (PDOX) model. [PDF]
, 2016 Melanoma is a recalcitrant disease in need of transformative therapuetics. The present study used a patient-derived orthotopic xenograft (PDOX) nude-mouse model of melanoma with a BRAF-V600E mutation to determine the efficacy of temozolomide (TEM ...
Chmielowski, Bartosz +14 more
core +2 more sources