The fate of melanin in the epidermis is of great interest due to its involvement in numerous physiological and pathological processes in the skin. Melanin localization can be assessed ex vivo and in vivo using its distinctive optical properties.
B. P. Yakimov+5 more
doaj +1 more source
Microscale Thermophoresis as a Screening Tool to Predict Melanin Binding of Drugs
Interactions between drugs and melanin pigment may have major impacts on pharmacokinetics. Therefore, melanin binding can modify the efficacy and toxicity of medications in ophthalmic and other disease of pigmented tissues, such as melanoma.
Laura Hellinen+5 more
doaj +1 more source
Melanin Made by Dopamine Oxidation: Thin Films and Interactions with Polyelectrolyte Multilayers [PDF]
The spontaneous oxidation of dopamine in slightly alkaline solutions was investigated on the basis of the work of Lee and others [Science, 318:426-430, 2007], and the reaction product was identified as dopamine-melanin. The ability of melanin to covalently bind amine functional groups was confirmed by quantification of the corresponding binding sites ...
arxiv
Quantitative scattering of melanin solutions [PDF]
The optical scattering coefficient of a dilute, well solubilised eumelanin solution has been accurately measured as a function of incident wavelength, and found to contribute less than 6% of the total optical attenuation between 210 and 325nm. At longer wavelengths (325nm to 800nm) the scattering was less than the minimum sensitivity of our instrument.
arxiv +1 more source
Synthesis of water-soluble melanin [PDF]
Melanins are promising materials for organic bioelectronics devices like transistors, sensors and batteries. However, in general, melanin either natural or synthetic has low solubility in most solvents. In this study, the chemical structural changes of melanin synthesized, by the auto oxidation of L-DOPA, are analyzed for a new synthetic procedure ...
arxiv
Protection of melanized Cryptococcus neoformans from lethal dose gamma irradiation involves changes in melanin's chemical structure and paramagnetism. [PDF]
Certain fungi thrive in highly radioactive environments including the defunct Chernobyl nuclear reactor. Cryptococcus neoformans (C. neoformans), which uses L-3,4-dihydroxyphenylalanine (L-DOPA) to produce melanin, was used here to investigate how gamma ...
Abdelahad Khajo+7 more
doaj +1 more source
Pathloss modeling for in-body optical wireless communications [PDF]
Optical wireless communications (OWCs) have been recognized as a candidate enabler of next generation in-body nano-scale networks and implants. The development of an accurate channel model capable of accommodating the particularities of different type of tissues is expected to boost the design of optimized communication protocols for such applications.
arxiv
Electronic Properties of Random Polymers: Modelling Optical Spectra of Melanins [PDF]
Melanins are a group of complex pigments of biological origin, widely spread in all species from fungi to man. Among diverse types of melanins, the human melanins, eumelanins,are brown or black nitrogen-containing pigments, mostly known for their photoprotective properties in human skin.
arxiv
A Quantum Yield Map for Synthetic Eumelanin [PDF]
The quantum yield of synthetic eumelanin is known to be extremely low and it has recently been reported to be dependent on excitation wavelength. In this paper, we present quantum yield as a function of excitation wavelength between 250 and 500 nm, showing it to be a factor of 4 higher at 250 nm than at 500 nm.
arxiv +1 more source
Non-contact, in-vivo, functional, and structural ophthalmic imaging using multimodal photoacoustic remote sensing (PARS) microscopy and optical coherence tomography (OCT) [PDF]
Early diagnosis of ocular diseases improves the understanding of pathophysiology and helps with accurate monitoring and effective treatment. Advanced multimodal ocular imaging platforms play a crucial role in the visualization of the ocular components and provide clinicians with a valuable tool for evaluating different eye diseases. Here, for the first
arxiv