Results 41 to 50 of about 80,218 (306)

Biomimetic Polymerization of Tellurocysteine: Breaking the Natural Amino Acid Radioprotection Limitation

Advanced Science, EarlyView.
Inspired by natural amino acid polymer‐melanin systems, this study strategically incorporated tellurocysteine to develop advanced radiation‐shielding materials. This approach transformed the primary interaction mechanism between melanin‐based materials and incident photons from Compton scattering to the photoelectric effect. Tellurocysteine‐polymerized
Wei Chen, Hanjie Zhu, Yue Zhang, Yuqing Qiao, Ruotong Deng, Huaping Xu, Wei Cao   +6 more
wiley   +1 more source

Antioxidant activities from melanin pigment produced by marine actinobacterium of Streptomyces species

Journal of Advanced Pharmaceutical Technology & Research, 2022
Melanin is macromolecules which have been developed while oxidative polymerization of phenolic compounds. It has been found that the majority of marine organisms produce melanin pigment.
M I Sheefaa, Pitchiah Sivaperumal
doaj   +1 more source

Melanin-Like Nanoquencher on Graphitic Carbon Nitride Nanosheets for Tyrosinase Activity and Inhibitor Assay

, 2016
Graphitic C3N4 (g-C3N4) nanosheets are a type of emerging graphene-like carbon-based nanomaterials with high fluorescence and large specific surface areas that hold great potential for biosensor applications. However, current g-C3N4 based biosensors have
Liu Xu (472677), Jin-Wen Liu (2940852), Jian-Hui Jiang (12075), Yu-Min Wang (1572673), Lu-Ying Duan (2940849), Hao Tang (44155), Ru-Qin Yu (12079)   +6 more
core   +1 more source

Tyrosinase Driven‐Intracellular Polymerization of a Porphyrin Derivative Induced Immunogenic Death of Melanoma Cells and Strengthened Photodynamic Therapy

Advanced Science, EarlyView.
This study uses tyrosinase, which is highly expressed in melanoma, to drive porphyrins to polymerize and self‐assemble within tumor cells to form retented microstructures. This process induces immunogenic death and activates immune responses (M1 macrophages, dendritic cells, CD8+T cells), turning “cold” tumors into “hot” tumors.
Mian Tang, Junteng Qiu, Yunfeng Lu, Yahui Song, Xinyu Zhou, Tianshun Duan, Xuanqi Peng, Caixia Yin, Cheng Gao, Ruibing Wang   +9 more
wiley   +1 more source

Preliminary characterisation of the neuropeptide melanin concentrating hormone in humans [PDF]

, 2010
Melanin concentrating hormone (MCH) is an orexigenic neuropeptide expressed centrally in the zona incerta and lateral hypothalamus. Evidence from rodent studies implicates hypothalamic MCH in the modulation of varied and diverse physiological functions ...
Naufahu, J.
core   +1 more source

Radical-Enriched Artificial Melanin

, 2020
Melanin is a class of ubiquitous, heterogeneous, polymeric pigments. One of the most unusual features of melanin is the presence of stable persistent radicals, which has been reported to relate to ionizing radiation protection, including X-rays and gamma
Mao H., Stoddart J. F., Mantanona A. J., Jiao Y., Caponetti V., Wasielewski M. R., Gianneschi N. C., Zang N., Thompson M. P., Montalti M., Cao W., Rinehart J. D., McCallum N. C., Battistella C.   +13 more
core   +2 more sources

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, EarlyView.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Differential Antifungal Activity of Human and Cryptococcal Melanins with Structural Discrepancies

Frontiers in Microbiology, 2017
Melanin is a pigment found in all biological kingdoms, and plays a key role in protection against ultraviolet radiation, oxidizing agents, and ionizing radiation damage. Melanin exerts an antimicrobial activity against bacteria, fungi, and parasites.
Néstor Correa, Néstor Correa, Néstor Correa, Cristian Covarrubias, Paula I. Rodas, Germán Hermosilla, Verónica R. Olate, Verónica R. Olate, Cristián Valdés, Wieland Meyer, Fabien Magne, Cecilia V. Tapia, Cecilia V. Tapia   +12 more
doaj   +1 more source

Melanin-concentrating hormone in peripheral circulation in the human [PDF]

, 2017
Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide with a well-characterised role in energy homeostasis and emergent roles in diverse physiologic functions such as arousal, mood and reproduction.
Murray, J.F., Fiuza Brito, M., Doslikova, B., Naufahu, J., Alzaid, F., Valencia, T.   +5 more
core   +1 more source

Hair Follicle Seedling Cryomicroneedles from Hierarchical Microfluidic Organoid on a Chip

Advanced Science, EarlyView.
In this paper, a hierarchical microfluidic chip is developed to produce uniform hair follicle organoids (HFOs) in cryomicroneedles. Cryopreservation agents encapsulate HFOs, preserving viability and hair growth potential. The cryomicroneedles enable simple intradermal transplantation with good skin penetration.
Xinyue Cao, Dongyu Xu, Minhui Lu, Yuanjin Zhao   +3 more
wiley   +1 more source