Results 11 to 20 of about 14,691 (270)

Melanization in Cryptococcus neoformans Requires Complex Regulation

mBio, 2020
The fungal human pathogen Cryptococcus neoformans undergoes melanization in response to nutrient starvation and exposure to exogenous melanin precursors.
Radames J. B. Cordero, Emma Camacho, Arturo Casadevall   +2 more
doaj   +3 more sources

Late sporogonic stages of Plasmodium parasites are susceptible to the melanization response in Anopheles gambiae mosquitoes [PDF]

Frontiers in Cellular and Infection Microbiology
The malaria-causing parasites have to complete a complex infection cycle in the mosquito vector that also involves attack by the insect’s innate immune system, especially at the early stages of midgut infection.
Suheir Zeineddine, Sana Jaber, Sally A. Saab, Johnny Nakhleh, George Dimopoulos, Mike A. Osta   +5 more
doaj   +3 more sources

Hemocyte Changes During Immune Melanization in Bombyx Mori Infected with Escherichia coli

Insects, 2019
Hemolymph melanization is a conserved immune response in insects and other arthropods. However, the physiological process of the hemolymph system in the melanization response is hardly studied.
Tian Li, Dengfeng Yan, Xiaohui Wang, Liang Zhang, Ping Chen   +4 more
doaj   +3 more sources

More Than Black or White: Melanization and Toll Share Regulatory Serine Proteases in Drosophila

Cell Reports, 2019
The melanization response is an important defense mechanism in arthropods. This reaction is mediated by phenoloxidases (POs), which are activated by complex extracellular serine protease (SP) cascades.
Jan Paul Dudzic, Mark A Hanson, Igor Iatsenko   +2 more
exaly   +3 more sources

Unculturable bacteria exploit a secretory protein to antagonize insect melanization for persistent infection [PDF]

mBio
Phloem-inhabiting unculturable bacterial pathogens are persistently transmitted by insect vectors. However, how they evade insect immune responses to ensure persistent transmission remains unknown. The important melanization immune response in insects is
You Li, Yu Du, Dongsheng Ren, Yu Bin, Qian Chen, Taiyun Wei   +5 more
doaj   +3 more sources

Nucleoprotein of a Rice Rhabdovirus Serves as the Effector to Attenuate Hemolymph Melanization and Facilitate Viral Persistent Propagation in its Leafhopper Vector

Frontiers in Immunology, 2022
Melanization in the hemolymph of arthropods is a conserved defense strategy against infection by invading pathogens. Numerous plant viruses are persistently transmitted by insect vectors, and must overcome hemolymph melanization.
Ruonan Zhang, Xiao-Feng Zhang, Yunhua Chi, Yuanyuan Xu, Hongyan Chen, Zhongxin Guo, Taiyun Wei   +6 more
doaj   +2 more sources

How to eliminate pathogen without killing oneself? Immunometabolism of encapsulation and melanization in Drosophila

Frontiers in Immunology, 2023
Cellular encapsulation associated with melanization is a crucial component of the immune response in insects, particularly against larger pathogens.
Tomas Dolezal
doaj   +2 more sources

The CLIP-domain serine protease CLIPC9 regulates melanization downstream of SPCLIP1, CLIPA8, and CLIPA28 in the malaria vector Anopheles gambiae.

PLoS Pathogens, 2020
The arthropod melanization immune response is activated by extracellular protease cascades predominantly comprised of CLIP-domain serine proteases (CLIP-SPs) and serine protease homologs (CLIP-SPHs).
Gregory L Sousa, Ritika Bishnoi, Richard H G Baxter, Michael Povelones   +3 more
doaj   +2 more sources

Inhibition of melanization by serpin-5 and serpin-9 promotes baculovirus infection in cotton bollworm Helicoverpa armigera. [PDF]

PLoS Pathogens, 2017
Melanization, an important insect defense mechanism, is mediated by clip-domain serine protease (cSP) cascades and is regulated by serpins. Here we show that proteolytic activation of prophenoloxidase (PPO) and PO-catalyzed melanization kill the ...
Chuanfei Yuan, Longsheng Xing, Manli Wang, Xi Wang, Mengyi Yin, Qianran Wang, Zhihong Hu, Zhen Zou   +7 more
doaj   +2 more sources

Role of Cln1 during melanization of Cryptococcus neoformans [PDF]

Frontiers in Microbiology, 2015
Cryptococcus neoformans is an opportunistic fungal pathogen that has several well-described virulence determinants. A polysaccharide capsule and the ability to produce melanin are among the most important.
Rocío eGarcía-Rodas, Nuria eTrevijano-Contador, Elvira eRomán, Guilhem eJanbon, Frederique eMoyrand, Jesus ePla, Arturo eCasadevall, Oscar eZaragoza   +7 more
doaj   +2 more sources