Results 181 to 190 of about 67,182 (234)

Molecular remodeling of the myocardium in mice with melanocortin-4 receptor deletion before cardiac function impairment. [PDF]

PLoS One
Wang X, Qi Y, Zhu Z, Wang C, Zhang Z, Jia H, Xia L, Meng K, Yuan J.   +8 more
europepmc   +1 more source

Fish melanocortin system [PDF]

European Journal of Pharmacology, 2011
Melanocortin signalling is mediated by binding to a family of G protein-coupled receptors that positively couple to adenylyl cyclase. Tetrapod species have five melanocortin (MC(1)-MC(5)) receptors. The number of receptors varies in fish, zebrafish, for example, having six melanocortin receptors, with two copies of the melanocortin MC(5) receptor ...
Jose Miguel Cerda-Reverter, Maria Josep Agulleiro, Elisa Sanchez   +2 more
exaly   +4 more sources

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The melanocortin system

American Journal of Physiology-Endocrinology and Metabolism, 2003
The melanocortin system consists of melanocortin peptides derived from the proopiomelanocortin gene, five melanocortin receptors, two endogenous antagonists, and two ancillary proteins. This review provides an abbreviated account of the basic biochemistry, pharmacology, and physiology of the melanocortin system and highlights progress made in four ...
Ira, Gantz, Tung M, Fong
openaire   +2 more sources

Melanocortins and reproduction

Brain Research Reviews, 2002
Obesity, anorexia and general body weight fluctuations cause a variety of effects on the reproductive system. Our understanding of the neuro-biological mechanisms of the connections between body weight and the reproductive axis is not especially developed despite a number of interesting physiological observations.
Helgi B, Schiöth, Hajime, Watanobe
openaire   +2 more sources

Brain effects of melanocortins☆

Pharmacological Research, 2009
The melanocortins (alpha, beta and gamma-melanocyte-stimulating hormones: MSHs; adrenocorticotrophic hormone: ACTH), a family of pro-opiomelanocortin (POMC)-derived peptides having in common the tetrapeptide sequence His-Phe-Arg-Trp, have progressively revealed an incredibly wide range of extra-hormonal effects, so to become one of the most promising ...
BERTOLINI, Alfio, TACCHI, Raffaella, VERGONI, Anna Valeria   +2 more
openaire   +2 more sources

Melanocortin Signalling Mechanisms

2010
The melanocortin family are a series of very potent neuropeptides that derive from a parent propopiomelanocortin molecule (POMC). They are expressed predominantly in the brain, specifically the pituitary gland and also in the central nervous system. Interestingly, recent research also suggests the existence of regulatory functions outside of the brain,
Paula Eves, J. W. Haycock
openaire   +2 more sources

Characterization of Melanocortin Receptors

Current Protocols in Pharmacology, 2003
AbstractThis unit describes a Scintillation Proximity Assay (SPA) for the measurement of ligand binding to melanocortin receptors (MCRs) using membranes prepared from cell lines stably expressing recombinant MCRs. It provides a facile method for determining the affinity of compounds at MC1R, MC3R, MC4R, or MC5R.
Aaron S, Goetz, Diane M, Ignar
openaire   +2 more sources