Results 191 to 200 of about 67,182 (234)
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Melanocortins and cardiovascular regulation
European Journal of Pharmacology, 1998The melanocortins form a family of pro-opiomelanocortin-derived peptides that have the melanocyte-stimulating hormone (MSH) core sequence, His-Phe-Arg-Trp, in common. Melanocortins have been described as having a variety of cardiovascular effects. We review here what is known about the sites and mechanisms of action of the melanocortins with respect to
D H, Versteeg +3 more
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Melanocortins and the melanocortin 1 receptor, moving translationally towards melanoma prevention
Archives of Biochemistry and Biophysics, 2014Beginning in the last decade of the twentieth century, the fields of pigment cell research and melanoma have witnessed major breakthroughs in the understanding of the role of melanocortins in human pigmentation and the DNA damage response of human melanocytes to solar ultraviolet radiation (UV).
Zalfa A, Abdel-Malek +5 more
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Melanocortins and Adrenocortical Function
2000Although the existence of a functional relationship between the pituitary gland and the adrenal cortex was revealed by the classic studies of Smith almost seventy years ago (1),the first purified adrenocorticotropin (ACTH) preparation from sheep pituitary was obtained only in 1954 (2), and its structure was determined in the following few years (3). In
Bégeot, Martine, Saez, J.M.
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The Journal of Pharmacology and Experimental Therapeutics, 1995
The melanocortins are peptide products of proopiomelanocortin post-translational processing that, among other functions, are thought to influence cognition. Recently, we isolated genes encoding two human melanocortin receptors, the melanocortin-3 receptor (hMC3R) and the melanocortin-4 receptor (hMC4R), which are expressed primarily in brain.
H, Miwa +4 more
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The melanocortins are peptide products of proopiomelanocortin post-translational processing that, among other functions, are thought to influence cognition. Recently, we isolated genes encoding two human melanocortin receptors, the melanocortin-3 receptor (hMC3R) and the melanocortin-4 receptor (hMC4R), which are expressed primarily in brain.
H, Miwa +4 more
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Melanocortins in Brain Inflammation: The Role of Melanocortin Receptor Subtypes
2010The melanocortins (MC) are released from neurons and paracrine cells in the CNS where they are involved in important physiological functions, including regulation of body temperature and immune responses. MC bind to melanocortin receptors, a class of cell surface G-protein-coupled receptors. Of the five subtypes of MC receptors that have been cloned in
Ruta, Muceniece, Maija, Dambrova
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Uspekhi fiziologicheskikh nauk, 2009
Melanocortin system consists of native melanocortin peptides (ACTH, MSH and their fragments), melanocortin receptors (MC1R-MC5R) and their endogenous antagonists. Melanocortins have a wide spectrum of physiological activity. These peptides improve memory and attention, facilitate neuromuscular regeneration, exert neuroprotective action, affect the ...
N G, Levitskaia, A A, Kamenskiĭ
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Melanocortin system consists of native melanocortin peptides (ACTH, MSH and their fragments), melanocortin receptors (MC1R-MC5R) and their endogenous antagonists. Melanocortins have a wide spectrum of physiological activity. These peptides improve memory and attention, facilitate neuromuscular regeneration, exert neuroprotective action, affect the ...
N G, Levitskaia, A A, Kamenskiĭ
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2000
Cutaneous melanoma is the cancer with the steepest increase in incidence in the Caucasian population (1) and is currently the most common cancer among young adults (2). Mortality rates are increasing correspondingly, and the disease still leads to death in one of every four to five patients.
Alex N. Eberle +2 more
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Cutaneous melanoma is the cancer with the steepest increase in incidence in the Caucasian population (1) and is currently the most common cancer among young adults (2). Mortality rates are increasing correspondingly, and the disease still leads to death in one of every four to five patients.
Alex N. Eberle +2 more
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Melanocortins and Pigmentation
2000It all began in 1916, the story not only for the melanocortins and pigmentation but also for the entire field of pituitary endocrinology. Two independent papers appeared in Science by two young biologists, Philip E. Smith in California (1) and Bennett M. Allen in Kansas (2).
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