Results 101 to 110 of about 60,692 (262)

Prolonged exposure to artificial light and carcinogenesis: A systematic review of oncostatic mechanisms associated with melatonin pathways

Photochemistry and Photobiology, EarlyView.
Exposure to artificial light at night (ALAN), particularly at blue wavelengths, disrupts circadian rhythms by suppressing melatonin, thereby increasing cancer susceptibility. This systematic review consolidates evidence linking prolonged ALAN exposure to an elevated risk of breast and prostate tumors.
Gabriel Barboza, Jêmina Oliveira, Antônio Ferreira, Renan Lopes, Marli Cupertino   +4 more
wiley   +1 more source

5-HT obesity medication efficacy via POMC activation is maintained during aging [PDF]

, 2014
Peer reviewedPublisher ...
Billups, Brian, Burdakov, Denis, Burke, Luke K, D'Agostino, Giuseppe, Doslikova, Barbora, Evans, Mark L, Farooq, Gala, Garfield, Alastair S, Heisler, Lora, Low, Malcolm, Rubinstein, Marcelo   +10 more
core   +3 more sources

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

A nutrigenetic approach to investigate the relationship between metabolic traits and vitamin D status in an Asian Indian population [PDF]

, 2020
Studies in Asian Indians have examined the association of metabolic traits with vitamin D status. However, findings have been quite inconsistent. Hence, we aimed to explore the relationship between metabolic traits and 25-hydroxyvitamin D [25(OH)D ...
Alathari, Buthaina E., Anjana, Ranjit Mohan, Bodhini, Dhanasekaran, Jayashri, Ramamoorthy, Lakshmipriya, Nagarajan, Lovegrove, Julie A., Mohan, Viswanathan, Pradeepa, Rajendra, Radha, Venkatesan, Rani, Coimbatore Subramanian Shanthi, Sudha, Vasudevan, Vimaleswaran, Karani S.   +11 more
core   +1 more source

Role of Acid‐Sensing Ion Channels 1a in the Regulation of Obesity and the Gut Microbiota

Obesity, Volume 34, Issue 2, Page 372-381, February 2026.
ABSTRACT Objective Acid‐sensing ion channels are proton‐activated ion channels predominantly found in the nervous system. They are well known to affect metabolic and neurological health, yet their role in obesity and gut physiology remains unclear. This study investigates how systemic deletion of Asic1a influences obesity, metabolic, and gut‐based ...
Jane Shearer, Morris H. Scantlebury, Oghenefejiro Erome‐Utunedi, Anamika Choudhary, Jennifer A. Thompson, Christina Ohland, Kathy D. McCoy, Chunlong Mu   +7 more
wiley   +1 more source

Modeling Obesity and Weight Loss in Mice Using Novel AAV Approaches

Obesity, Volume 34, Issue 2, Page 417-427, February 2026.
ABSTRACT Objective This study utilized AAV gene delivery as an approach to induce and reverse hyperphagia in mice. We hypothesized that the delivery of orexigenic neuropeptides to the brain via AAV precipitates obesity and that the implementation of genetic switches to reverse transgene expression would elicit weight loss.
Hunter G. Sellers, Zachary L. Brown, Noureen S. Khalil, Stephen B. Haigh, Mitchell A. Shivers, Tej V. Patel, Austin T. Joshua, Neal L. Weintraub, Scott A. Barman, Eric J. Belin de Chantemele, Sergei A. Kirov, David W. Stepp, David J. R. Fulton   +12 more
wiley   +1 more source

mTORC1 and CB1 receptor signaling regulate excitatory glutamatergic inputs onto the hypothalamic paraventricular nucleus in response to energy availability

Molecular Metabolism, 2019
Objective: The hypothalamic paraventricular nucleus (PVN) is a key target of the melanocortin system, which orchestrates behavioral and metabolic responses depending on energy availability.
Wilfrid Mazier, Nicolas Saucisse, Vincent Simon, Astrid Cannich, Giovanni Marsicano, Federico Massa, Daniela Cota   +6 more
doaj   +1 more source

Activation of melanocortin receptors MC1 and MC5 attenuates retinal damage in experimental diabetic retinopathy [PDF]

, 2016
We hypothesize that melanocortin receptors (MC) could activate tissue protective circuit in a model of streptozotocin- (STZ-) induced diabetic retinopathy (DR) in mice.
D'Amico, M., D'Amico, M., Di Filippo, C., Di Filippo, C., Ferraraccio, F., Ferraraccio, F., Gesualdo, C., Gesualdo, C., Getting, S.J., Getting, S.J., Grieco, P., Grieco, P., Kaneva, M.K., Kaneva, M.K., Maisto, R., Maisto, R., Merlino, F., Merlino, F., Perretti, M., Perretti, M., Rossi, S., Rossi, S., Simonelli, F., Simonelli, F., Surace, E., Surace, E., Testa, F., Testa, F., Trotta, M.C., Trotta, M.C.   +29 more
core   +4 more sources

Targeted Next‐Generation Sequencing of the Leptin‐Melanocortin Pathway in Severe Obesity

Obesity, Volume 34, Issue 2, Page 499-511, February 2026.
ABSTRACT Objective Pathogenic variants in five established leptin‐melanocortin pathway genes (LEP, LEPR, MC4R, PCSK1, POMC) are associated with severe early‐onset obesity and are targets for emerging treatments. However, these variants are rare in these patients, suggesting the involvement of additional genes interacting with this pathway. Methods Next‐
Nathan Faccioli, Chrisitne Poitou, Mathieu Georget, Françoise Bertin, Ahlam Azar‐Kolakez, Claire Carette, Pauline Faucher, Blandine Gatta‐Cherifi, Julie Gonneau‐Lejeune, Agnès Linglart, Karine Clément, Johanne Le Beyec‐Le Bihan, Béatrice Dubern   +12 more
wiley   +1 more source

Probing the Role of Melanocortin Type 1 Receptor Agonists in Diverse Immunological Diseases

Frontiers in Pharmacology, 2019
Background: The melanocortin α-melanocyte stimulating hormone (α-MSH), an endogenous peptide with high affinity for the melanocortin 1 receptor (MC1r), has demonstrated prevention and reversal of intestinal and ocular inflammation in animal models ...
Carl Spana, Andrew W. Taylor, David G. Yee, Marie Makhlina, Wei Yang, John Dodd   +5 more
doaj   +1 more source