Results 151 to 160 of about 994,457 (252)

Transcriptomics Reveal Molecular Signatures of a Resolved Sexual Conflict and Potential Association With Colour Polymorphism in Tawny Owls

Molecular Ecology, Volume 35, Issue 7, April 2026.
ABSTRACT Genome sharing in gonochorous species is expected to result in intraspecific conflicts due to intersexual competition. The emergence of sexual dimorphism is thus connected to the evolution of mechanisms that, starting from a similar genomic background, produce sufficiently disparate phenotypes to attenuate sexually antagonistic selection. From
Miguel Baltazar‐Soares, Melanie J. Heckwolf, Marc P. Hoeppner, Patrik Karell, Dominic Wright, Jan‐Åke Nilsson, Jon E. Brommer   +6 more
wiley   +1 more source

Cold exposure and metabolic health: Therapeutic potential for obesity, diabetes, and beyond

Physiological Reports, Volume 14, Issue 7, April 2026.
Abstract Cold exposure, an inducer of brown adipose tissue thermogenesis, has been applied to relieve exercise‐induced pain and inflammation, modulate circulation and enhance metabolism. However, its role in managing metabolic diseases and the underlying molecular mechanisms remain inadequately understood.
Xirong Li, Jiale Dang, Rui Guo, Helen R. Griffiths, Shemin Lu, Dan Gao   +5 more
wiley   +1 more source

Editorial: Melanocortins and melanocortin receptors in the regulation of inflammation: mechanisms and novel therapeutic strategies

Frontiers in Immunology, 2023
Petteri Rinne, Petteri Rinne, Andrew W. Taylor, Trinidad Montero-Melendez   +3 more
doaj   +1 more source

Skin Type, Melanoma, and Melanocortin 1 Receptor Variants [PDF]

Journal of Investigative Dermatology, 1999
Healy, Eugene, Todd, Carole, Jackson, Ian J., Birch-Machin, Mark, Rees, Jonathan L.   +4 more
openaire   +3 more sources

Melanocortin 1 receptor ligands and methods of use

, 2016
The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality ...
David L. Morse, Victor J. Hruby, Jonathan L. Sessler, Robert J. Gillies, Josef Vagner, Kevin N. Sill, Natalie M. Barkey, Narges K. Tafreshi, Christian Preihs   +8 more
openaire   +2 more sources

UV AND MELANOCORTIN 1 RECEPTORS

, 2010
Les ultraviolets A (UVA) sont carcinogènes et produisent des espèces réactives de l'oxygène (ERO). Le récepteur à la mélanocortine de type 1 (MC1R) est un récepteur couplé aux protéines G (RCPG) qui est impliqué dans la mélanogénèse et dans l'inflammation cutanée.
openaire   +1 more source

A Side-by-Side Comparison of Wildtype and Variant Melanocortin 1 Receptor Signaling with Emphasis on Protection against Oxidative Damage to DNA. [PDF]

Int J Mol Sci, 2023
Cerdido S, Sánchez-Beltrán J, Lambertos A, Abrisqueta M, Padilla L, Herraiz C, Olivares C, Jiménez-Cervantes C, García-Borrón JC.   +8 more
europepmc   +1 more source

Absorption, metabolism, and excretion of [¹⁴ C]dersimelagon, an investigational oral selective melanocortin 1 receptor agonist, in preclinical species and healthy volunteers. [PDF]

Pharmacol Res Perspect, 2023
Tsuda M, Ogawa K, Endou T, Goto T, Ogasawara Y, Ogasawara A.   +5 more
europepmc   +1 more source

Curcumin ameliorates oxaliplatin-induced allodynia response and melanocortin downregulation in the spinal cord

Research Results in Pharmacology
Introduction: Oxaliplatin is a platinum-based chemotherapy agent that often causes chemotherapy-induced peripheral neuropathy (CIPN). This effect limits the potential activity and decreases the cancer patient’s quality of life. Melanocortin and transient
Alma Nuril Aliya, Luke Wongso, Diah Ayu Wakita Trimanda , Risda Maulida, I Nengah Budi Sumartha, Samirah Samirah, Abdulloh Machin, Long Chiau Ming, Abdelhakim Bouyahya, Mahardian Rahmadi, Junaidi Khotib, Сhrismawan Ardianto   +11 more
doaj   +1 more source

Negative Modulation of B Cell Activation by Melanocortin 1 Receptor Signaling Protects against Membranous Nephropathy. [PDF]

J Am Soc Nephrol, 2023
Chen B, Guan X, Gunning WT, Ge Y, Gohara AF, Dworkin LD, Gong R.   +6 more
europepmc   +1 more source