Results 61 to 70 of about 994,457 (252)

Loss‐of‐function mutations in the melanocortin 1 receptor cause disruption of dorso‐ventral countershading in teleost fish

Pigment Cell & Melanoma Research, 2019
The melanocortin 1 receptor (MC1R) is the central melanocortin receptor involved in vertebrate pigmentation. Mutations in this gene cause variations in coat coloration in amniotes.
L. Cal, P. Suarez‐Bregua, I. Braasch, U. Irion, R. Kelsh, J. M. Cerdá-Reverter, J. Rotllant   +6 more
semanticscholar   +1 more source

Feeding induced by cannabinoids is mediated independently of the melanocortin system. [PDF]

PLoS ONE, 2008
Cannabinoids, the active components of marijuana, stimulate appetite, and cannabinoid receptor-1 (CB1-R) antagonists suppress appetite and promote weight loss.
Puspha Sinnayah, Erin E Jobst, Joseph A Rathner, Angela D Caldera-Siu, Luciana Tonelli-Lemos, Aaron J Eusterbrock, Pablo J Enriori, Emmanuel N Pothos, Kevin L Grove, Michael A Cowley   +9 more
doaj   +1 more source

Current evidence for a modulation of low back pain by human genetic variants [PDF]

, 2009
The manifestation of chronic back pain depends on structural, psychosocial, occupational and genetic influences. Heritability estimates for back pain range from 30% to 45%. Genetic influences are caused by genes affecting intervertebral disc degeneration
Aberle, Agarwal, Agrawal, Aladin, Anderson, Andersson, Annunen, Arnold, Ashford, Atkinson, Bandell, Battie, Battie, Bautista, Bejaoui, Berthele, Beyer, Blau, Bond, Brown, Brown, Brown, Campa, Caraco, Carbonell Sala, Carragee, Cascorbi, Cho, Chou, Chou, Cipollone, Collart, Cox, Dalen, Daly, Dawkins, Dayer, Dayer, Diatchenko, Diatchenko, Diatchenko, Dick, Doehring, Eckhardt, Einarsdottir, Fillingim, Foulkes, Fu, Gasche, Goldberg, Grant, Gross, Gursoy, Gutierrez-Roelens, Hamdani, Hartvigsen, Hayashida, Hernandez, Higashino, Hirose, Hoyland, Hummel, Hustmyer, Ikeda, Indo, Irmgard Tegeder, Jayamanne, Jim, Jörn Lötsch, Kales, Kalichman, Karppinen, Karsak, Kawaguchi, Kawaguchi, Kawasaki, Khoromi, Kim, Kim, Kim, Kim, Kirchheiner, Kirchheiner, Klepstad, Knoeringer, Kroslak, Kuisma, Kung, Lafreniere, Landau, Langdahl, Le Maitre, Lee, Lettre, Leyne, Lichtman, Liem, Lorenzo, Lotsch, Lotsch, Lotsch, Lotsch, Lotsch, Lotsch, Lovlie, Lu, Luoma, Lötsch, MacDonald, Macpherson, Madadi, Manning, McNamara, Meeus, Meller, Meller, Mignat, Mio, Miura, Mogil, Mogil, Morrison, Nguyen, Noponen-Hietala, Noponen-Hietala, Oakley, Oertel, Oertel, Oertel, Ofek, Ohtori, Oliveira, Paassilta, Papafili, Pilotto, Pluijm, Poulsen, Racz, Racz, Rakvag, Ralston, Ralston, Reyes-Gibby, Richards, Riviere, Roddier, Romberg, Russo, Sachse, Sakai, Schmidt, Schneider, Seki, Seki, Sindrup, Sipe, Skarke, Skarke, Slade, Slaugenhaupt, Solovieva, Solovieva, Solovieva, Solovieva, Solovieva, Srinivasan, Srinivasan, Stamer, Stamer, Steward, Stohler, Suzuki, Svendsen, Tadic, Takahashi, Tam, Tander, Tegeder, Tegeder, Thieme, Thomas, Trevisani, Uitterlinden, Ujike, van Meurs, Vargas-Alarcon, Verhoeven, Videman, Videman, Virtanen, Voronov, Vree, Wiesinger, Yamada, Yazdanpanah, Zhang, Zhang, Zhang, Zhang, Zubieta, Zuo   +200 more
core   +1 more source

Modulation of social behavior by the agouti pigmentation gene [PDF]

, 2014
Agouti is a secreted neuropeptide that acts as an endogenous antagonist of melanocortin receptors. Mice and rats lacking agouti (called non-agouti) have dark fur due to a disinhibition of melanocortin signaling and pigment deposition in the hair follicle.
Carola V, Gross CT, Novotny MV, Perlas E, Soini HA, Zonfrillo F   +5 more
core   +1 more source

High Polymorphism at the Human Melanocortin 1 Receptor Locus [PDF]

Genetics, 1999
Abstract Variation in human skin/hair pigmentation is due to varied amounts of eumelanin (brown/black melanins) and phaeomelanin (red/yellow melanins) produced by the melanocytes. The melanocortin 1 receptor (MC1R) is a regulator of eu- and phaeomelanin production in the melanocytes, and MC1R mutations causing coat color changes are ...
B K, Rana, D, Hewett-Emmett, L, Jin, B H, Chang, N, Sambuughin, M, Lin, S, Watkins, M, Bamshad, L B, Jorde, M, Ramsay, T, Jenkins, W H, Li   +11 more
openaire   +2 more sources

Association of single nucleotide polymorphism in melanocortin receptor gene with egg production traits in lohmann brown chickens [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2017
Melanocortin receptor (MC4R) plays an important role in central melanocortin system and regulation of feed intake in birds. In this study the melanocortin gene (MC4R) was proposed as a candidate gene for egg production traits (yield and weight) in ...
Karim EL-SABROUT, Sarah AGGAG
doaj   +1 more source

L-Cell Expression of Melanocortin-4-Receptor Is Marginal in Most of the Small Intestine in Mice and Humans and Direct Stimulation of Small Intestinal Melanocortin-4-Receptors in Mice and Rats Does Not Affect GLP-1 Secretion

Frontiers in Endocrinology, 2021
The molecular sensors underlying nutrient-stimulated GLP-1 secretion are currently being investigated. Peripheral administration of melanocortin-4 receptor (MC4R) agonists have been reported to increase GLP-1 plasma concentrations in mice and humans but ...
Rune E. Kuhre, Rune E. Kuhre, Rune E. Kuhre, Ida M. Modvig, Ida M. Modvig, Sara L. Jepsen, Sara L. Jepsen, Hüsün S. Kizilkaya, Cecilie Bæch-Laursen, Cecilie Bæch-Laursen, Christopher A. Smith, Frank Reimann, Fiona M. Gribble, Mette M. Rosenkilde, Jens J. Holst, Jens J. Holst   +15 more
doaj   +1 more source

Pro-resolving and anti-arthritic properties of the MC1 selective agonist PL8177

Frontiers in Immunology, 2022
BackgroundMelanocortins are peptides endowed with anti-inflammatory and pro-resolving activities. Many of these effects are mediated by the Melanocortin receptor 1 (MC1) as reported in several experimental settings.
Jose Garrido-Mesa, Bethan Lynne Thomas, John Dodd, Carl Spana, Mauro Perretti, Mauro Perretti, Trinidad Montero-Melendez, Trinidad Montero-Melendez   +7 more
doaj   +1 more source

Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads

Nature Communications, 2019
Melanocortin-1 receptor is a palmitoylated protein and variants of the receptor are associated with red hair colour and susceptibility to melanoma. Here, the authors describe a method to enhance the palmitoylation of the receptor, which can inhibit ...
Shuyang Chen, Changpeng Han, Xiao Miao, Xin Li, Chengqian Yin, Junrong Zou, Min Liu, Shanshan Li, Lukasz Stawski, Bo Zhu, Qiong Shi, Zhi-Xiang Xu, Chunying Li, Colin R. Goding, Jun Zhou, Rutao Cui   +15 more
doaj   +1 more source

Inhibition of the central melanocortin system decreases brown adipose tissue activity[S]

Journal of Lipid Research, 2014
The melanocortin system is an important regulator of energy balance, and melanocortin 4 receptor (MC4R) deficiency is the most common monogenic cause of obesity.
Sander Kooijman, Mariëtte R. Boon, Edwin T. Parlevliet, Janine J. Geerling, Vera van de Pol, Johannes A. Romijn, Louis M. Havekes, Illiana Meurs, Patrick C.N. Rensen   +8 more
doaj   +1 more source