Results 71 to 80 of about 994,457 (252)

The effects of BMS-470539 on lipopolysaccharide-induced acute lung injury [PDF]

Acute and Critical Care, 2019
Background Overactivation of inflammatory cells, including macrophages and neutrophils, is associated with acute lung injury. BMS-470539 is a selective agonist of melanocortin 1 receptor, which triggers the inhibition of proinflammatory responses ...
Eun-A Jang, Jin-Young Kim, Tran Duc Tin, Ji-A Song, Seong-Heon Lee, Sang-Hyun Kwak   +5 more
doaj   +1 more source

Endocrinologic Control of Men's Sexual Desire and Arousal/Erection [PDF]

, 2016
Several hormones and neurotransmitters orchestrate men's sexual response, including the appetitive (sexual desire) and consummative (arousal and penile erection) phases.
Aversa, Antonio, Burnett, Arthur L., Corona, Giovanni, Isidori, Andrea, Maggi, Mario   +4 more
core   +1 more source

Understanding pseudo-albinism in sole (Solea senegalensis): a transcriptomics and metagenomics approach [PDF]

, 2019
Pseudo-albinism is a pigmentation disorder observed in flatfish aquaculture with a complex, multi-factor aetiology. We tested the hypothesis that pigmentation abnormalities are an overt signal of more generalised modifications in tissue structure and ...
Carballo, Carlos, Codoñer, Francisco M., Costa, Rita A., Guerreiro, Claudia, Manchado, Manuel, Martinez-Blanch, Juan F., Pinto, Patricia IS, Power, Deborah   +7 more
core   +1 more source

The evolution and comparative neurobiology of endocannabinoid signalling [PDF]

, 2012
CB(1)- and CB(2)-type cannabinoid receptors mediate effects of the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide in mammals. In canonical endocannabinoid-mediated synaptic plasticity, 2-AG is generated postsynaptically by diacylglycerol ...
Devane W. A., Maurice R. Elphick, Montell C., Soderstrom K., Soderstrom K.   +4 more
core   +1 more source

Genetic Diversity, Adaptation, Wild Introgression, and Coat Color Mutation of Golden Yak

Animal Research and One Health, EarlyView.
Genetic diversity, adaptation, wild introgression, and coat color mutation of golden yak from two populations on the Qinghai‐Xizang Plateau. ABSTRACT The golden yak lives on the Qinghai‐Xizang Plateau with a golden coat and adapts to high altitudes and strong ultraviolet environment. The golden coat is a prominent phenotype in many domesticated species,
Huixuan Yan, Jialei Chen, Chuzhao Lei, Fengwei Zhang, Shunzhong He, Weiru Song, Hongyan Ma, Shuling Li, Guomei Li, Laba Yongcuo, Jianlin Han, Johannes A. Lenstra, Qiang Zhang, Rende Song, Basang Wangdui, Ningbo Chen   +15 more
wiley   +1 more source

Development of a genetically encoded melanocortin sensor for high sensitivity in vivo imaging

Molecular Metabolism
Objective: The central melanocortin system, composed of peptides derived from pro-opiomelanocortin (POMC) such as the melanocyte-stimulating hormones (α-, β-, γ-MSH) and melanocortin 4 receptors (MC4R), along with the agouti-related protein (AgRP), plays
Yoon Namkung, Tal Slutzki, Joao Pedroso, Xiaohong Liu, Paul V. Sabatini, Maia V. Kokoeva, Stéphane A. Laporte   +6 more
doaj   +1 more source

Sun Exposure and Reduced Risk of Multiple Sclerosis

Pediatric Neurology Briefs, 2008
The association between red hair color (RHC) melanocortin 1 receptor genotype, past environmental sun exposure, and risk of multiple sclerosis (MS) was investigated in a population-based case-control study in Tasmania, Australia, involving 136 cases with
J Gordon Millichap
doaj   +1 more source

Disruption of type 3 adenylyl cyclase expression in the hypothalamus leads to obesity [PDF]

, 2016
Evidence from human studies and transgenic mice lacking the type 3 adenylyl cyclase (AC3) indicates that AC3 plays a role in the regulation of body weight. It is unknown in which brain region AC3 exerts such an effect.
Cao, Hong, Chen, Xuanmao, Storm, Daniel R., Yang, Yimei   +3 more
core   +2 more sources

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

Vagal Blocking for Obesity Control : a Possible Mechanism-Of-Action [PDF]

, 2016
14 September 2016 Erratum to: Vagal Blocking for Obesity Control: a Possible Mechanism-Of-Action Helene Johannessen, David Revesz, Yosuke Kodama, Nikki Cassie, Karolina P Skibicka, Perry Barrett, Suzanne Dickson, Jens Holst, Jens Rehfeld, Geoffrey van ...
Adan, Roger, Barrett, Perry, Ben-Menachem, Elinor, Cassie, Nikki, Chen, Duan, Dickson, Suzanne, Holst, Jens, Johannessen, Helene, Kodama, Yosuke, Kulseng, Bård, Rehfeld, Jens, Revesz, David, Skibicka, Karolina P, van der Plasse, Geoffrey, Zhao, Chun-Mei   +14 more
core   +1 more source