Specific Functions of Melanocortin 3 Receptor (MC3R) [PDF]
JCRPE, 2023 Melanocortin 3 receptor (MC3R) is a G-protein coupled receptor which has been defined mostly as a regulator of the appetite/hunger balance mechanisms to date.
Tulin Yanik, Seyda Tugce Durhan
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Topmouth culter melanocortin-3 receptor: regulation by two isoforms of melanocortin-2 receptor accessory protein 2 [PDF]
Endocrine Connections, 2021 Melanocortin-3 receptor (MC3R) is a regulator of energy homeostasis, and interaction of MC3R and melanocortin-2 receptor accessory protein 2 (MRAP2) plays a critical role in MC3R signaling of mammals.
Ren-Lei Ji +6 more
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Pharmacological modulation of the cAMP signaling of two isoforms of melanocortin-3 receptor by melanocortin receptor accessory proteins in the tetrapod Xenopus laevis [PDF]
Endocrine Connections, 2021 As a member of the seven-transmembrane rhodopsin-like G protein-coupled receptor superfamily, the melanocortin-3 receptor (MC3R) is vital for the regulation of energy homeostasis and rhythms synchronizing in mammals, and its pharm acological effect could
Ying Xu +12 more
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Ring finger protein 11 inhibits melanocortin 3 and 4 receptor signaling [PDF]
Frontiers in Endocrinology, 2016 Intact melanocortin signaling via the G protein-coupled receptors (GPCRs) melanocortin receptor 4 (MC4R) and melanocortin receptor 3 (MC3R) is crucial for body weight maintenance.
Anne Müller +16 more
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Melanocortin 3 receptor regulates hepatic autophagy and systemic adiposity [PDF]
Nature CommunicationsSystemic lipid homeostasis requires hepatic autophagy, a major cellular program for intracellular fat recycling. Here, we find melanocortin 3 receptor (MC3R) regulates hepatic autophagy in addition to its previously established CNS role in systemic ...
Tushar P. Patel +17 more
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Cross-species studies implicate the melanocortin 3 receptor more strongly in the control of pubertal development than energy balance [PDF]
Molecular MetabolismHypothalamic neurons expressing either POMC or AGRP sense nutritional state directly and indirectly and transmit these neuropeptide signals to other brain centres through the melanocortin 3 and 4 receptors. MC4R is primarily concerned with the control of
Katie Duckett +24 more
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Functional Characterization of Melanocortin-3 Receptor in a Hibernating Cavefish Onychostoma macrolepis [PDF]
Animals, 2021 Melanocortin-3 receptor (MC3R) plays an important role in the energy homeostasis of animals under different nutritional conditions. Onychostoma macrolepis is a hibernating cavefish found in the northern part of the Yangtze River, and its adaptation to a ...
Lian Wu +8 more
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Melanocortin-3 receptor expression in AgRP neurons is required for normal activation of the neurons in response to energy deficiency. [PDF]
Cell Rep, 2023 Gui Y +5 more
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Investigating the role of melanocortinergic, glutamatergic and neuropeptide Y systems on hypophagia caused by gastric inhibitory polypeptide (GIP) in broilers [PDF]
Poultry Science: Appetite control and the metabolic rate of energy expenditure are under the influence of a broad suite of biochemical messengers, which include peptide-based signals, hormonal agents, and neurotransmitters.
Maryam Lotfi Gharaie +3 more
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Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets. [PDF]
PLoS ONE, 2011 INTRODUCTION: The melanocortin system plays an important role in energy homeostasis. Mice genetically deficient in the melanocortin-3 receptor gene have a normal body weight with increased body fat, mild hypophagia compared to wild-type mice.
José L Santos +14 more
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