Results 141 to 150 of about 58,672 (263)

The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia. [PDF]

Sci Transl Med, 2021
Sweeney P, Bedenbaugh MN, Maldonado J, Pan P, Fowler K, Williams SY, Gimenez LE, Ghamari-Langroudi M, Downing G, Gui Y, Hadley CK, Joy ST, Mapp AK, Simerly RB, Cone RD.   +14 more
europepmc   +1 more source

Subthreshold activation of the melanocortin system causes generalized sensitization to anorectic agents in mice

The Journal of Clinical Investigation
The melanocortin-3 receptor (MC3R) regulates GABA release from agouti-related protein (AgRP) nerve terminals and thus tonically suppresses multiple circuits involved in feeding behavior and energy homeostasis.
Naima S. Dahir, Yijun Gui, Yanan Wu, Patrick R. Sweeney, Alix A.J. Rouault, Savannah Y. Williams, Luis E. Gimenez, Tomi K. Sawyer, Stephen T. Joy, Anna K. Mapp, Roger D. Cone   +10 more
doaj   +1 more source

Melanocortin 3 receptor-expressing neurons in the ventromedial hypothalamus promote glucose disposal. [PDF]

Proc Natl Acad Sci U S A, 2021
Sutton Hickey AK, Goforth PB, Gonzalez IE, Dell'Orco J, Pei H, Myers MG, Olson DP.   +6 more
europepmc   +1 more source

Functional Characterization of Melanocortin-3 Receptor Variants Identify a Loss-of-Function Mutation Involving an Amino Acid Critical for G Protein-Coupled Receptor Activation [PDF]

, 2004
Ya‐Xiong Tao, Deborah L. Segaloff
openalex   +1 more source

Whole-brain efferent and afferent connectivity of mouse ventral tegmental area melanocortin-3 receptor neurons. [PDF]

J Comp Neurol, 2021
Dunigan AI, Swanson AM, Olson DP, Roseberry AG.   +3 more
europepmc   +1 more source

Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign. [PDF]

J Med Chem, 2021
Doering SR, Freeman K, Debevec G, Geer P, Santos RG, Lavoi TM, Giulianotti MA, Pinilla C, Appel JR, Houghten RA, Ericson MD, Haskell-Luevano C.   +11 more
europepmc   +1 more source

Searching for the relationship between the parameters of metabolic syndrome and the rs17782313 (T>C) polymorphism of the MC4R gene in postmenopausal women

Clinical Interventions in Aging, 2017
Jacek Brodowski,1 Małgorzata Szkup,2 Anna Jurczak,2 Sylwia Wieder-Huszla,2 Agnieszka Brodowska,3 Maria Laszczyńska,4 Beata Karakiewicz,5 Katarzyna Kęcka,1 Elżbieta Grochans2 1Primary Care Department, Pomeranian Medical University in Szczecin ...
Brodowski J, Szkup M, Jurczak A, Wieder-Huszla S, Brodowska A, Laszczyńska M, Karakiewicz B, Kęcka K, Grochans E   +8 more
doaj  

Preliminary investigation of potential links between pigmentation variants and opioid analgesic effectiveness in horses during cerebrospinal fluid centesis

BMC Veterinary Research
Background The pleiotropic effects of the melanocortin system show promise in overcoming limitations associated with large variations in opioid analgesic effectiveness observed in equine practice. Of particular interest is variation in the melanocortin-1-
Elouise K. Bacon, Callum G. Donnelly, Rebecca R. Bellone, Bianca Haase, Carrie J. Finno, Brandon D. Velie   +5 more
doaj   +1 more source

Melanocortin 2, 3 and 4 Receptor Gene Expressions are Downregulated in CD8⁺ T Cytotoxic Lymphocytes and CD19⁺ B Lymphocytes in Rheumatoid Arthritis Responding to TNF‐α Inhibition [PDF]

, 2017
Marlene Andersen, Ivan Nagaev, Mitchell Meyer, Olga Nagaeva, Jarl E. S. Wikberg, Lucia Mincheva‐Nilsson, Grethe Neumann Andersen   +6 more
openalex   +1 more source

Central Serotonin and Melanocortin Pathways Regulating Energy Homeostasis

, 2003
It is now established that the hypothalamus is essential in coordinating endocrine, autonomic, and behavioral responses to changes in energy availability.
Bagnol, Bruinvels, Connolly, Cowley, Elias, Elias, Elmquist, Fan, Fan, Freedman, Giraudo, Grill, Guy-Grand, Hahn, Haskell-Luevano, Heisler, Heisler, Heisler, Hill, Hinney, Huszar, Jacobowitz, Kask, Kishi, Kiss, McMinn, Molineaux, Mountjoy, Peroutka, Roselli-Rehfuss, Rowland, Rowland, Simansky, Tecott, Tiligada, Tooqi, Vickers, Wirth, Wright, Yen, Yeo   +40 more
core   +1 more source