Regulation of energy rheostasis by the melanocortin-3 receptor. [PDF]
Sci Adv, 2018 The melanocortin-3 receptor acts as a rheostat on energy homeostasis through presynaptic inhibition of MC4R neuronal activity.
Ghamari-Langroudi M +6 more
europepmc +7 more sources
Evaluation of hypothalamic murine and human melanocortin 3 receptor transcript structure. [PDF]
Biochem Biophys Res Commun, 2014 The melanocortin 3 receptor (MC3R) is involved in regulation of energy homeostasis. However, its transcript structure is not well understood. We therefore studied initiation and termination sites for hypothalamic murine Mc3r and human MC3R transcripts.
Taylor-Douglas DC +5 more
europepmc +5 more sources
Biomolecules, 2022 The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), have crucial roles in regulating energy homeostasis. The melanocortin-2 receptor accessory proteins (MRAPs, MRAP1 and MRAP2) have been shown to regulate neural ...
Ren-Lei Ji +2 more
doaj +4 more sources
Regulation of Melanocortin-3 and -4 Receptors by Isoforms of Melanocortin-2 Receptor Accessory Protein 1 and 2 [PDF]
Biomolecules, 2022 The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), play essential non-redundant roles in the regulation of energy homeostasis. Interaction of neural MCRs and melanocortin-2 receptor accessory proteins (MRAPs, MRAP1
Ren-Lei Ji, Ya-Xiong Tao
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Gender-specific roles for the melanocortin-3 receptor in the regulation of the mesolimbic dopamine system in mice. [PDF]
Endocrinology, 2014 Lippert RN, Ellacott KL, Cone RD.
europepmc +2 more sources
The accessory protein MRAP2 directly interacts with melanocortin-3 receptor to enhance signaling. [PDF]
Sci SignalJamaluddin A +8 more
europepmc +3 more sources
Melanocortin-3 receptor regulates the normal fasting response [PDF]
Proceedings of the National Academy of Sciences, 2012 The melanocortin-3 receptor–deficient (MC3-R −/− ) mouse exhibits mild obesity without hyperphagia or hypometabolism. MC3-R deletion is reported to increase adiposity, reduce lean mass and white adipose tissue inflammation, and increase sensitivity to salt-induced hypertension. We show here that the MC3-R
Benjamin J. Renquist +6 more
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Molecular cloning and pharmacological characterization of porcine melanocortin-3 receptor [PDF]
Journal of Endocrinology, 2007 Mouse gene targeting studies revealed that the melanocortin-3 receptor (MC3R) affected feeding efficiency and fat storage in mice. The functions of the MC3R in other mammalian species remain to be investigated. We are interested in exploring the functions of the porcine MC3R (pMC3R) in regulating fat storage because of the economical importance of ...
Zhen‐Chuan Fan +2 more
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MON-724 Effect Of CDD866, An Anti-activin Type II Receptor Antibody, On The Melanocortin 3 Receptor (MC3R) Deficiency Obesity Phenotype [PDF]
J Endocr SocEliza A Jansujwicz +4 more
europepmc +3 more sources
Melanocortin antagonist tetrapeptides with minimal agonist activity at the mouse melanocortin-3 receptor. [PDF]
ACS Med Chem Lett, 2015 The melanocortin system regulates many important functions in the body. There are five melanocortin G protein-coupled receptor subtypes known to date. Herein, we report a structure-activity relationship (SAR) study of a tetrapeptide lead discovered through a double substitution strategy at the melanocortin core His-Phe-Arg-Trp sequence.
Doering SR +2 more
europepmc +7 more sources