Results 21 to 30 of about 58,672 (263)

Melanocortin 3 Receptor Signaling in Midbrain Dopamine Neurons Increases the Motivation for Food Reward. [PDF]

Neuropsychopharmacology, 2016
Pandit R, Omrani A, Luijendijk MC, de Vrind VA, Van Rozen AJ, Ophuis RJ, Garner K, Kallo I, Ghanem A, Liposits Z, Conzelmann KK, Vanderschuren LJ, la Fleur SE, Adan RA.   +13 more
europepmc   +3 more sources

Functional Characterization of Melanocortin-3 Receptor In Rainbow Trout (Oncorhynchus Mykiss) [PDF]

Fish Physiology and Biochemistry, 2021
Abstract The melanocortin-3 receptor (MC3R) is an important regulator of energy homeostasis and inflammation in mammals. However, its function in teleost fish needs to be further explored. In this study, we characterized rainbow trout MC3R (rtMC3R), which encoded a putative protein of 331 amino acids.
Huixia Yu, Yang Li, Weijia Song, Hui Wang, Haolin Mo, Qiao Liu, Xinmiao Zhang, Zebin Jiang, Lixin Wang   +8 more
openalex   +5 more sources

Lack of association between coat color abnormalities in Bali cattle (Bos javanicus) and the coding regions of the MC1R and KIT genes [PDF]

Veterinary World, 2023
Background and Aim: Coat color variations in cattle are known to be influenced by the melanocortin 1 receptor (MC1R) and receptor tyrosine kinase (KIT) genes.
Jakaria Jakaria, Kholijah Kholijah, Sri Darwati, Qonita Rahman, Winni Liani Daulay, Ikhsan Suhendro, I. Made Londra, Mokhamad Fakhrul Ulum, Ronny Rachman Noor   +8 more
doaj   +1 more source

Pharmacological Evaluation of Melanocortin 2 Receptor Accessory Protein 2 on Axolotl Neural Melanocortin Signaling

Frontiers in Endocrinology, 2022
The Melanocortin-3 receptor (MC3R) and Melanocortin-4 receptor (MC4R), two members of the key hypothalamic neuropeptide signaling, function as complex mediators to control the central appetitive and energy homeostasis.
Xiaozhu Wang, Song Xue, Xiaowei Lei, Wenqi Song, Lei Li, Xuan Li, Yanbin Fu, Cong Zhang, Hailin Zhang, Hailin Zhang, Yao Luo, Meng Wang, Gufa Lin, Gufa Lin, Chao Zhang, Jing Guo   +15 more
doaj   +1 more source

Melanocortin-3-receptor gene variants in morbid obesity [PDF]

International Journal of Obesity, 2003
Linkage and knock-out mice studies suggest that the melanocortin-3-receptor (MC3R) is a candidate gene for obesity.To evaluate whether MC3R mutations underlie morbid obesity.MC3R coding and 5(')-flanking regions were sequenced in 48 subjects and the detected variants genotyped in 252 morbidly obese (BMI>/=40 kg/m(2)) Finns.
C, Schalin-Jäntti, K, Valli-Jaakola, L, Oksanen, E, Martelin, K, Laitinen, T, Krusius, P, Mustajoki, M, Heikinheimo, K, Kontula   +8 more
openaire   +2 more sources

Melanocortin receptor 3 and 4 mRNA expression in the adult female Syrian hamster brain

Frontiers in Molecular Neuroscience, 2023
Melanocortin 3 receptors (MC3R) and melanocortin 4 receptors (MC4R) are vital in regulating a variety of functions across many species. For example, the dysregulation of these receptors results in obesity and dysfunction in sexual behaviors.
Megan A. L. Hall, Abigail L. Kohut-Jackson, Anna C. Peyla, Gloria D. Friedman, Nicole J. Simco, Johnathan M. Borland, Robert L. Meisel   +6 more
doaj   +1 more source

Differential Signaling Profiles of MC4R Mutations with Three Different Ligands [PDF]

, 2020
The melanocortin 4 receptor (MC4R) is a key player in hypothalamic weight regulation and energy expenditure as part of the leptin-melanocortin pathway. Mutations in this G protein coupled receptor (GPCR) are the most common cause for monogenetic obesity,
Annibale, Paolo, Biebermann, Heike, Dimitriou, Ioanna Maria, Krude, Heiko, Kühnen, Peter, Lohse, Martin J., Paisdzior, Sarah, Scheerer, Patrick, Schöpe, Paul Curtis   +8 more
core   +3 more sources

Identification of novel GPCR partners of the central melanocortin signaling

Molecular Metabolism, 2021
Objective: Homo- or heterodimerization of G protein–coupled receptors (GPCRs) generally alters the normal functioning of these receptors and mediates their responses to a variety of physiological stimuli in vivo.
Yunpeng Li, Xiaozhu Wang, Liumei Lu, Meng Wang, Yue Zhai, Xiaolu Tai, Diliqingna Dilimulati, Xiaowei Lei, Jing Xu, Cong Zhang, Yanbin Fu, Shen Qu, Qingfeng Li, Chao Zhang   +13 more
doaj   +1 more source

Melanocortin-3 Receptors and Metabolic Homeostasis [PDF]

, 2013
Attenuated activity of the central nervous melanocortin system causes obesity and insulin resistance. Obese rodents treated with melanocortins exhibit improvements in obesity and metabolic homeostasis that are not mutually dependent, suggesting metabolic actions that are independent of weight changes.
Karima, Begriche, Clemencé, Girardet, Patricia, McDonald, Andrew A, Butler   +3 more
openaire   +2 more sources

The Role of Melanocortin 3 Receptor Gene in Childhood Obesity [PDF]

Diabetes, 2007
OBJECTIVE—Melanocortin 3 receptor (MC3R) plays a critical role in weight regulation of rodents, but its role in humans remains unclear. The objective of this study was to identify genetic variants of the MC3R gene and determine its association with childhood obesity.
Yung Seng Lee, Larry Kok Seng Poh, Betty Lay Kee Kek, Kah Yin Loke   +3 more
openalex   +4 more sources